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Tag: "variants" at biology news

Scientists find new genetic clue to cause of Alzheimer's disease

...ins of people with the disease. They identified 29 variants that mark relatively short segments of DNA where d...Scientists have previously identified three genes, variants of which can cause early onset Alzheimer's, and one that increases risk for the late onset form. Thi...

Scientists to track impact of Asian dust and pollution on clouds, weather, climate change

...cal Institute. "This mouse model and its future variants mark the first use of genetically produced light activation in the study of the intact mammalian brain, and we believe this advance in nerve circuit mapping will be to neurobiology what microarray technology has been to genomic science -- a fundament...

Common algae helps illustrate mammalian brain electrical circuitry

...cal Institute. "This mouse model and its future variants mark the first use of genetically produced light activation in the study of the intact mammalian brain, and we believe this advance in nerve circuit mapping will be to neurobiology what microarray technology has been to genomic science -- a fundament...

Producing medicines in plant seeds

...s. They have also demonstrated that these antibody variants are just as active as the whole antibodies that oc... it is now also clear that these kinds of antibody variants can be used in medical applications and that it is possible to produce them in the seeds of plants, ...

Scientists discover a new risk factor for Alzheimer's

...at there are at least two, and possibly more, gene variants at work here," said St George-Hyslop. "That's not ...loid-beta. Now we can add our new observation that variants of the SORL1 gene are associated with an increased risk of Alzheimer's." St George Hyslop said tha...

Tiny clue reveals new path toward heart disease

... it, as such a link would indicate that these gene variants were associated with the disease. The researchers first obtained DNA from 500 patients who had volunteered to be studied while being examined at the cardiac catheterization laboratories at Duke University Hospital. Using these DNA samples, the re...

Gene hunters close in on Lou Gehrig’s disease

... human genome. The researchers found 34 genetic variants that ALS patients were more likely to have compared to normal individuals without the disease. “This is the first major step toward understanding how genetics may influence the most common form of ALS,?says co-researcher Jeffrey D. Rothstein, M.D....

Turning a cellular sentinel into a cancer killer

...the cancer cells early on that there aren't enough variants left to get around the p53 pathway." Jacks added that "the main point is that—although there are differences between these mouse models and human cancers—we now can say with some confidence that established tumors are sensitive to p53 reactivation....

Genes and genius: Researchers confirm association between gene and intelligence

... next step is to look at the gene and its numerous variants to learn what is going on biologically that might affect cognitive performance. Presently, she says it's too early to predict how small changes in the gene might be influencing communication in the brain to affect intelligence, and she says it's near...

Pooled data examines if SNPs add to breast cancer risk

...ies has helped scientists examine specific genetic variants related to breast cancer incidence, according to a...re genetic changes. He writes, "If common genetic variants modulate susceptibility to common diseases such as breast cancer, we now have excellent tools to dis...

Fruit fly study identifies gene mutation that regulates sensitivity to alcohol

...hoGAP18B gene. They also isolated a number of gene variants of RhoGAP18B, each of which had a distinctly diffe...w signaling proteins encoded by the RhoGAP18B gene variants played an important role in reorganizing components of the adult fruit fly's central nervous system,...

Tulane researcher reports on origin of deadly fever outbreak

...al team of researchers identified multiple genetic variants of the virus in the outbreak, meaning the fever ma...sease. The discovery of multiple different genetic variants of the virus indicates that the two-year outbreak was fueled by repeated new introductions of the vi...

Leading reason for corneal transplants comes into focus

...ade me wonder, however, if there were more genetic variants of the disease out there." He stopped wondering a few years later when he examined the Indiana family and discovered what he thought at the time was the youngest case of FCD ever described in the scientific literature, the 10-year-old boy. However...

Bitter taste identifies poisons in foods

...vegetables is influenced by an interaction between variants of taste genes and the presence of naturally-occur...in support of this hypothesis by establishing that variants of the bitter taste receptor TAS2R38 can detect glucosinolates, a class of compounds with potentiall...

New technology used to construct the first map of structural variation in the human genome

...ntal and algorithmic methods to detect copy number variants (CNVs)--defined as large deletions and duplications of DNA segments. These technologies--reported today in the journal Genome Research --were used to create the first comprehensive map of CNVs in the human genome, concurrently published in Nature ...

Researchers make progress in studying genetic traits of India-born populations

...still suggest that the frequencies of many genetic variants are distinctive in India compared to other parts of the world. "We were struck both by the low level of diversity amongst people spanning such a large geographical region, and by the fact that people of the Indian sub-continent constituted a dist...

International team analyzes human genetic variation in key immune region

...rnative for characterizing the most common genetic variants in the region than standard HLA typing methods. Nearly three-quarters of the DNA samples that the scientists analyzed had been previously examined as part of the International Haplotype Map ("HapMap") Project, a worldwide scientific collaboration ...

When nerve cells can't make contact

...iated with autism, but were missing all four known variants of the protein simultaneously. The consequences are accordingly more drastic than with autistic patients, who only have one mutated neuroligin gene. Without any neuroligins, the function of the nervous system breaks down completely and the mutant ani...

Scientists work to identify genes that contribute to early heart attack risk

... tissue samples from the study looking for genetic variants that may predispose individuals to develop early a...ng about this study is the large number of genetic variants that we’re going to study," said Herrington. "Using special technology provided by Perlegen Sciences...

Inheriting a tendency to brain infection

...s disease are complex, involving different genetic variants interacting with each other and with the environment in subtle ways that add up to an overall predisposition or resistance. However, Michael Levin, professor of pediatrics and international child health at Imperial College, London, does not think...

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