Tag: "variants" at biology news

Genomic Analysis Uncovers New Targets for HIV Vaccine

...onal team of researchers has identified three gene variants in the DNA of 486 people infected with HIV that ap.... In the new analysis, patients with specific gene variants in key immune system cells appear to be much better at controlling the proliferation of the virus af...

Identified main genetic variants involved in response to HIV

...ol of viral infection. Results point to two gene variants related to the immune system. More precisely, thes...on, and is also located in chromosome 6. Genetic variants associated to genes encoding HLA-B and HLA-C molecular systems would explain up to 15% of viral load...

454 sequencing identifies HIV drug resistance at early stage

...fy previously undetectable rare drug resistant HIV variants in samples from an earlier performed clinical tria... the clinic. The additional low abundant resistant variants detected by Ultra Deep sequencing were found to be extremely important as it enabled the prediction ...

Genome of Clostridium botulinum reveals the background to world's deadliest toxin

...veral types of C. botulinum: although described as variants of a single species, they are really very different organisms linked simply because they have the deadly toxin. For each type, there is also a near-identical but harmless relative that lacks the toxin. C. sporogenes is the non-malignant, near twin of...

First confirmed common genetic risk factors for breast cancer

...ut the disease – has uncovered five common genetic variants that increase an individual’s risk for breast canc... study of breast cancer genes. The five genetic variants identified by Dr. Liu and collaborators occur more frequently among women with breast cancer than do...

'Personality-gene' makes songbirds curious

... exploratory behaviour than individuals with other variants (Proceedings of the Royal Society London B, 2 May 2007). There is already evidence that variations (polymorphisms) in neurotransmitter-related genes are associated with personality differences among humans. Research from the last decade suggested ...

Peramivir protects mice from lethal H5N1 infection

...nd we are currently studying the emergence of H5N1 variants that are resistant to this drug and may occur in the course of treatment," said Natalia A. Ilyushina, Ph.D., a postdoctoral fellow in Webster’s laboratory. Ilyushina is a co-author of the paper. ...

Survival of the rarest: Fruit flies shed light on the evolution of behavior

...ent selection." Essentially, it suggests that rare variants have a better chance of survival—just as a rare st...ck says these results may help explain why genetic variants such as these are common in nature. "In the case of fruit flies, one variant encourages the survival...

NIDA study identifies genes that might help some people abstain from smoking

...ibute to nicotine dependence.? Genes that harbor variants that contribute to both success in quitting smokin...on for continuing the search for even more genetic variants associated with smoking cessation success,?says Dr. Volkow. “We soon may be able to make use of this...

Study examines genetic risk factors for Alzheimer's disease

...n Molecular Genetics, tested more than 17,000 gene variants in 4,000 volunteers. Several genes were found to show evidence of contributing to Alzheimer?disease, the most interesting gene being ‘GALP?which could affect the development of tangles within brain cells, a hallmark of Alzheimer’s disease. Pro...

Study suggests some drug resistance to influenza B medications

...y to what had been hoped until now, some resistant variants are vigorous pathogens. Whether these viruses aris...lies or acquired from the community, the resistant variants may be here to stay. In light of the recent observation that oseltamivir may be less effective again...

Individual differences in a clock gene predict decline of performance during sleep deprivation

...t Biology, published by Cell Press. There are two variants of the PERIOD3 gene found in the human population, encoding either long or short versions of the corresponding protein. Each individual will possess two copies of the gene, either of which might be the long or short form. Previous work had indicated ...

UCSD researchers discover variants of natural tumor suppressor

... (UCSD) School of Medicine have now identified two variants of that enzyme which could provide new targets for...logical diseases to better survive. "Both PHLPP variants are important in cancer; the loss of a brake to any of the three Akt pathways sends 'go, go, go' si...

Synthetic peptide targets latent papilloma virus infections

...his will work generally for many different genetic variants of human papilloma virus, though it's too early to...olecular Cell. Many of the 90-plus known genetic variants or strains of HPV cause warts in surface tissues, including the penis, vagina and cervix, but three ...

Common gene version optimizes thinking -- but with a possible downside

...ost-mortem techniques to identify the human gene's variants and their functional consequences. Seventy five percent of subjects had the most common version of the gene, which boosted circuit activation, structural and functional connectivity and performance on thinking tasks, likely by increasing gene express...

Secret of worm's poison pill box protein could produce new natural insecticide

...e cabbage white butterfly caterpillar, there were variants of this family of toxic proteins (such as XptA2) that targeted other insects. Dr Sarah Lee from the University of Warwick said: "This research gives us crucial new insights into a family of naturally occurring proteins that are toxic to a number...

Yale biologists 'trick' viruses into extinction

...We proved the concept using a non-human virus, and variants of the bacteria cells it infects." In ecology, a habitat that supports population growth is termed a "source," whereas a non-supportive habitat is a "sink." This study reported on the success of phi-6 virus populations in environments containing d...

Scientists find new genes for Crohn's disease

...covery of these Crohn's disease-associated genetic variants has identified several key biological pathways that will be the focus of further research to understand how the debilitating inflammatory process is initiated and maintained in many cases of the disease. "As we collect more and more data from these ...

Researchers from the UGR use a bacterium to obtain biopreservatives from food

...sis dirigida' (Characterization of enterocin AS-48 variants via site-directed mutagenesis), explains that AS-48 is a bacteriocin (protein substance with antimicrobial activity) produced by Enterococcus faecalis S-48. "The bacteriocin is characterized by its circular structure —that is, because of the joining ...

Twin studies reveal genetic components leading to cardiac and kidney disease

...bjects with elevated CRP, multiple, common genetic variants were found along a pathway associated with the adrenergic system. Adrenergic stimulation is what is involved in the 'flight or fight' response, and results in an increased heart rate, sweating, and increased blood pressure. Evidence emerging from th...

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