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Tag: "variant" at biology news

Blood transfusion-transmitted infections: A global perspective

...articularly those due to emerging agents including variant Creutzfeldt-Jakob disease (vCJD) the human counterpart to mad cow disease. With regard to the emerging pathogens, several newly-developed pathogen-reduction technologies have been shown to be effective in destroying most bacteria, viruses and para...

Crohn's disease gene identified

...iguing because we appear to have identified a gene variant that protects against development of IBD," said Ch...ifferences in the CARD 15 gene, they found a third variant SNP, which was in a different gene on a different chromosome--the interleukin-23 receptor. "We k...

Cellular traffic backups implicated in skeletal malformations

...University of California at Davis report the human variant of this gene, which causes a craniofacial condition called CLSD (Cranio-Lenticulo-Sutural Dysplasia) with strikingly similar defects to the crusher fish. Although CLSD is a rare syndrome, there are hundreds of human congenital dysmorphologies of th...

Plant-derived molecules, genetic manipulation point to future chemoprevention methods

...reast cancer cells in mice. CDDO and its synthetic variant CDDO-ME are undergoing clinical trials for leukemia and solid tumors. Beginning at 10 weeks of age, mice that were genetically altered to become susceptible to breast cancer were fed either a control diet, a dose of CDDO-ME, LG 100268, or a combi...

Fruit fly study identifies gene mutation that regulates sensitivity to alcohol

...o cocaine and nicotine as well. Because this gene variant affected the behavioral response to substances of abuse, the researchers dubbed it white rabbit--a reference to the title of a 1960s song about drug-induced changes. "This study describes key molecular pathways and gene interactions that control ...

Gene linked with mental illness shapes brain region, researchers find

A gene variant associated with mental illness goes hand-in-hand with enlargement of a brain region that handles negative emotions, researchers at UT Southwestern Medical Center and the Central Texas Veterans Health Care System have found. The region of the brai...

New approach to BSE successful in lab

...this year’s Nobel Prize for Medicine. Scrapie is a variant of the cattle disease BSE and the human equivalent...on protein is known as PrP-Scr, whereas the normal variant is PrP-C. PrP-C seems to have a protective effect in diseases like a stroke. Interestingly, mice whi...

Evolution of influenza A virus

...fecting a host or the introduction of a particular variant from elsewhere. These factors make predicting future patterns of influenza virus evolution more difficult, as vaccine strain selection then becomes dependent upon intensive surveillance, whole-genome sequencing, and phenotypic analysis....

Living view in animals shows how cells decide to make proteins

...se the exon’s presence or absence determines which variant of the FGFR2 protein is produced, she said. Such subtle variations in proteins can alter the cell’s behavior, just as switching ingredients in a favorite recipe can change the food’s flavor, according to the scientists. "Viewing these decisions is...

Gene key to taste bud development identified

...ther set of experiments, Hogan's team used another variant of the mouse strain made by Pevny in which the SOX2 gene was altered to produce only low levels of SOX2. In these animals, the stem cells in the tongue were not transformed into taste buds, she said. Instead, the cells became the "scaly" cells that c...

Salmonella survives better in stomach due to altered DNA

...ormation can also be used to make a less dangerous variant of this infectious Salmonella. Such a harmless variant can be used as a vaccine. Salmonella serovar Typhimurium DT104 is an antibiotic-resistant pathog...

Genes and genius: Researchers confirm association between gene and intelligence

...es between two and four points, depending on which variant a person carries," Dick explains. "We did that all up and down the gene and found that the variations had cumulative effects, so that if one person had all of the 'good' variations and another all of the 'bad' variations, the difference in IQ might b...

Making mice with enhanced color vision

...some point in the past, random mutations created a variant of one receptor gene, located on the X chromosome, producing two different receptor types. Present-day New World (South American) monkeys still use this system, which means that in these monkeys only certain females can acquire trichromatic color vi...

Scientists discover a new risk factor for Alzheimer's

... different Alzheimer's variants of SORL1, but each variant might have been associated with a different SNP pattern. That complexity would have obscured the SNP marker patterns that the researchers were tracking. The importance of this work is that it identifies a new player among the mechanisms causing Al...

Producing medicines in plant seeds

...succeeded in achieving a high yield of an antibody variant in plants, which had been very difficult to do up ...in such a way that they would produce the antibody variant in their seeds. With their special technique, the scientists succeeded in producing seeds in which t...

Genes and biomarkers that allow doctors to choose the right therapy for the right patient

...ines. Each of these cell lines represents a single variant among the different genomic abnormalities found among breast cancers. They measured molecular profiles of each cell line and used these to identify subsets of cell lines that represent the subtypes observed in analyses of primary tumors. By corr...

Gene that makes people 'early to bed and early to rise' demystified

...ymptoms. The UCSF group had earlier discovered a variant of the human Per2 gene that causes FASPS. They also showed that the so-called "S662G" variant, in which the serine building block normally present at position 662 is replaced by glycine, prevented a regulatory enzyme from tacking a phosphate onto the...

Common gene version optimizes thinking -- but with a possible downside

... "Our results raise the question of whether a gene variant favored by evolution, that would normally confer advantage, may translate into a disadvantage if the prefrontal cortex is impaired, as in schizophrenia," added Daniel Weinberger, M.D. "Normally, enhanced cortex connectivity with the striatum would pr...

Individual differences in a clock gene predict decline of performance during sleep deprivation

...ed how individuals possessing only the longer gene variant and those possessing only the shorter one coped wi... 8 a.m.), during which individuals with the longer variant of the gene performed very poorly on tests for attention and working memory. The authors point ou...

Veterinary scientists explore poultry virus as cancer killer

...nia Tech are looking at how a genetically modified variant of Avian Newcastle disease virus (NDV) can treat human prostate cancer. Dr. Elankurmaran Subbiah, assistant professor in the Department of Biomedical Sciences and Pathobiology, was awarded a prestigious research grant by the Department of Defense....

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