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Tag: "variant" at biology news

Human brain is still evolving

... each haplotype is, in essence, a distinct genetic variant of the gene. They found that they could further br...n the case of Microcephalin, the origin of the new variant coincides with the emergence of culturally modern humans," said Lahn. "And the ASPM new variant orig...

Studies on human genome variation provide insight into disease

...and genomic coverage. In some cases, a particular variant at one locus is perfectly associated with a specific variant at another locus; in other words, the two markers are "genetically indistinguishable." Dr. Lon Card...

Housecat-sized Siberian tiger cubs get collared

...and genomic coverage. In some cases, a particular variant at one locus is perfectly associated with a specific variant at another locus; in other words, the two markers are "genetically indistinguishable." Dr. Lon Card...

Agricultural workers at increased risk for infection with animal flu viruses

...kers may be at a much greater risk of developing a variant H5N1 and passing it along to non-agricultural workers," Gray says. "Not protecting agricultural workers could amplify influenza transmission among humans and domestic animals during a pandemic and cause considerable damage to the swine and poultry in...

New study expands understanding of the role of RNA editing in gene control

... gene can produce a number of related but distinct variant proteins. Most recently, scientists have discovered an extensive family of small molecules called microRNAs, or miRNAs, that appear to target and inactivate particular messenger RNAs. This targeted gene silencing is now seen as one of the body's prim...

First big influenza genome study reveals flu evolution

...u season, the Nature study reports, a minor H3N2 variant reassorted, or genetically mixed, with the dominan...monstrates that these influenza subpopulations, or variant strains, represent a pool of genetic resources that the influenza virus can draw upon," says Salzber...

Scientists pinpoint inflammation gene

...The statistical analysis identified one particular variant in the SEPS1 gene a variation in the gene's promo...responds to stress," Curran said. "The more common variant the one most people have is the 'good form' of SEPS1 that is more efficient at perceiving and resp...

Free-energy theory borne out in large-scale protein folding

...on monomeric lactose repressor protein, or MLAc, a variant of the protein used by E. coli to regulate expression of the proteins that transport and metabolize lactose. MLAc contains about 360 amino acids. While scientists know proteins containing 100 or fewer amino acids fold in a very cooperative (all-or-n...

Key brain regulatory gene shows evolution in humans

...ed to lower primates, humans possess a distinctive variant in a regulatory segment of the prodynorphin gene, ...f regulatory proteins called "neuropeptides." This variant increases the amount of prodynorphin produced in the brain. While the researchers do not understand...

Gene variation affects tamoxifen's benefit for breast cancer

...at the Mayo Clinic, tested the most common genetic variant responsible for lowering the CYP2D6 enzyme, and found that women with this genetic variant were almost twice as likely to see their breast cancer return. Up to 10 percent of women inherit thi...

Ancient humans brought bottle gourds to the Americas from Asia

...aeological enigma by explaining how a domesticated variant of a species native to Africa ended up millennia ago in places as far removed as modern-day Florida, Kentucky, Mexico and Peru. The work, by a team of anthropologists and biologists from Harvard University, the Smithsonian Institution's National Mus...

New U. of Colorado at Boulder flu chip may help combat future epidemics, pandemics

...est for all known flu virus strains as well as new variant strains, was evaluated for three primary subtypes of flu in the October CDC test -- the avian flu strain H5N1, and two of the most common human flu types worldwide in recent winters, H1N1 and H3N2. The chip was more than 90 percent accurate and will...

Scientists fetch useful information from dog genome publications

...lains. "This is consistent with our finding that a variant on the X chromosome plays a role in skeletal size determination." ...

Dog genome sequenced

...lains. "This is consistent with our finding that a variant on the X chromosome plays a role in skeletal size determination." ...

Whole-genome study at Johns Hopkins reveals a new gene associated with abnormal heart rhythm

...cs on April 30. "In addition to finding a genetic variant that could be of clinical value for sudden cardiac death, this study also demonstrates how valuable large-scale genomics studies can be in detecting novel biological targets," says the study's senior author, Aravinda Chakravarti, Ph.D., director of t...

New evidence questions the simple link between prion proteins and madcow disease

... containing a large amount of the disease specific variant of the PrP protein and watched how it was taken up. They saw the abnormal PrP was rapidly taken up by finger-like projections called villi and passed in to the lymph. It was not, however, taken up by structures called Peyer's nodules, that are belie...

Researchers map of genetic variations implicated in disease

...egion of 160,000 bases that is up to 200-fold less variant between chromosomes sharing part of the same HLA type, suggesting these individuals most likely shared a common ancestor as recently as 50,000 years ago." Swapping of ancestral sequence blocks is a potential mechanism (identity-by-descent) whereby ...

Feinstein researchers identify intelligence gene

... general cognitive ability in carriers of the risk variant compared with non-carriers in two independent grou...was significantly impaired in carriers of the risk variant in both the schizophrenia group and the healthy volunteers as compared with the non-carriers. "Whil...

Natural selection at single gene demonstrated

...ts over 1,102 short fragments of the genome. Each variant was assigned a score based on the similarity of tw...The higher the score, the less likely it is that a variant could have arisen and spread randomly. The scoring formula accounts for the greater similarity expe...

Aggression-related gene weakens brain's impulse control circuits

...f normal people, we were able to see how this gene variant biases the brain toward impulsive, aggressive beha...les have two copies, one of which will be of the H variant in most cases. Several previous studies had linked increased serotonin during development with vio...

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