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Tag: "variant" at biology news

Gene variations explain drug dose required to control seizures

...e drugs and variation in the candidate genes. One variant of a gene known as CYP2C9, which encodes a liver e...toin taken by patients with epilepsy. Moreover, a variant of a second gene, called SCN1A, with activity in the brain, was found significantly more often in pa...

Researchers trace evolution to relatively simple genetic changes

...nments, he added, "we wondered whether the genetic variant (the mutant gene) that controls this trait might s...mor, and we found a very low level of this genetic variant in the marine population." So, he said, "the marine fish actually carry the genes for this alternat...

Octopuses occasionally stroll around on two arms, UC Berkeley biologists report

...nments, he added, "we wondered whether the genetic variant (the mutant gene) that controls this trait might s...mor, and we found a very low level of this genetic variant in the marine population." So, he said, "the marine fish actually carry the genes for this alternat...

Fibril Shape Is The Basis Of Prion Strains And Cross-species Prion Infection

...ed to tainted beef products, but very few cases of variant Creutzfeld-Jakob." He says there "must be protective mechanisms working there, but we don't know what they are." The other members of the Weissman research team include Motomasa Tanaka and Peter Chien. The Weissman study was supported by Howard Hug...

Increased risk of osteoporosis associated with gene that one in five people have

...dicine in St. Louis demonstrated that in women the variant gene speeds up the breakdown of estrogen and is as...ta showed a strong correlation between the genetic variant and low bone density." The research team measured bone density in both the spine and the upper femu...

Brain Scans Reveal How Gene May Boost Schizophrenia Risk

...tional Institute of Mental Health (NIMH). The gene variant produced a telltale pattern of activity linked to production of a key brain messenger chemical. The study found that increased activity in the front of the brain predicted increases in the neurotransmitter dopamine in the middle of the brain in subj...

First technology to remove prions that cause vCJD from blood launched

The risk of receiving blood contaminated with variant Creutzfeldt-Jakob (vCJD) prions may no longer be a concern for the thousands of people who require a transfusion. Pall Corporation (NYSE: PLL) announced today the Council of Europe (CE) marking of its Leukotrap® Affinity Prion Reduction Filter System...

Mouse gene shows new mechanism behind cardiac infarction in man

...dies of two patient groups revealed that a certain variant of the human homologue of the gene was more common in people who had a history of cardiac infarction than those without. “This is an example of how an unbiased genetic strategy based on a mice model can teach us more about common human diseases,?say...

Tendency to hair loss inherited from the mother

...ected lay the gene for the androgen receptor. "One variant of this gene was found among men who suffered from...rogen receptors in the scalp Probably the genetic variant results in more androgen receptors in the scalp. "Our findings permit two explanations," Axel Hillme...

To Stop Evolution: New Way Of Fighting Antibiotic Resistance Demonstrated By Scripps Scientists

...to rifampicin or ciprofloxin, when they harbored a variant of LexA that was catalytically inactive. In control experiments, the rodents were given rifampicin or ciprofloxin, and the scientists found that nearly all the wild-type E. coli cells had grown fully resistant to the antibiotics after three days. Th...

Research into how prions act in the brain could hold the key to defeating diseases

...re have been 148 deaths from confirmed or probable variant CJD (vCJD) in the UK. This is the human disease thought to be caused by eating food contaminated with prions that is also responsible for the epidemic of BSE or 'mad cow disease' in cattle. Research has already found that the highly-infectious prion...

Newly discovered protein an important tool for sleeping sickness research

...because it is coated with a surface antigen called variant surface glycoprotein (VSG). The human body makes antibodies for VSG, but trypanosomes randomly switch to another antigen when the organisms divide and reproduce. Trypanosomes whose VSG has switched evade the antibodies the human immune system made to...

Breakthrough System for Understanding Ocean Plant Life Announced

...because it is coated with a surface antigen called variant surface glycoprotein (VSG). The human body makes antibodies for VSG, but trypanosomes randomly switch to another antigen when the organisms divide and reproduce. Trypanosomes whose VSG has switched evade the antibodies the human immune system made to...

Depression gene may weaken mood-regulating circuit

...ve emotion. People with the depression-linked gene variant showed less gray matter and weaker connections in ...ported studies had shown that inheriting the short variant more than doubles risk of depression following life stresses,** boosts amygdala activity while viewi...

Genomics researchers discover protein deficit that causes drug toxicity

... European genetic background has two copies of the variant gene -- specifically, a switch in 2 out of 245 amino acids -- that results in the absence of the protein needed to properly metabolize thiopurine drugs. In patients with the genetic defect, instead of helping heal, a standard dose of thiopurine drugs...

Variant prion protein causes infection but no symptoms

...in deer and elk. Now, new research suggests that a variant form of abnormal prion protein--one lacking an "anchor" into the cell membrane--may be unable to signal cells to start the lethal disease process, according to scientists at the Rocky Mountain Laboratories (RML), part of the National Institute of All...

Learning how SARS spikes its quarry

... SARS epidemic would be to predict whether a given variant of the virus will jump species or move laterally from one human to the other. Understanding the structure of this complex will help us understand what these mutations in the spike protein mean in terms of infectivity," Harrison said. According to H...

Corn grain mould used as pesticide

...n with Beelzebub. "Apart from that the aspergillus variant has to be so sturdy that it can assert itself against its toxic cousin in the wild," Professor Sikora says. Promising strains among 3,000 isolates The Federal Ministry of Economic Co-operation and Development (the BMZ) is supporting the project unt...

Nanotechnology to provide portable genetic risk detection

...er evaluation trials later this year, a commercial variant of the system is likely to be produced within one or two years by Sensia, a 15-month-old spin-off company from the CNM. ...

New results validating Pall prion reduction filter disclosed at ISBT Congress

...o blood services worldwide as new threats, such as variant Creutzfeldt-Jakob Disease (vCJD), emerge. An update on the latest measures to protect the public from the human form of Bovine Spongiform Encephalopathy (BSE), commonly called Mad Cow Disease, and minimize risk of transmission through blood transfusi...

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