Bioluminescence at the service of a novel cerebral imaging technique
...nique for the in vivo imaging of neuronal function using bioluminescence, based on a GFP-aequorin fusion pr...n learning and memory phenomena. Furthermore, using this imaging technique, it has been possible to record neurons in the ellipsoid body, a structure i...World's largest flower evolved from family of much tinier blooms
...of life in the past 25 years have tracked ancestry using molecular markers in genes governing photosynthesis. Rafflesia is a non-photosynthetic parasite, and those genes have apparently been abandoned, meaning that to determine its lineage we had to look at other parts of the plant's genome." Davis and h...Paleontologists discover new mammal from Mesozoic Era
... complex body parts can be explained by evolution, using exquisitely preserved fossils," said H. Richard Lane, program director in NSF's Division of Earth Sciences, which co-funded the discovery with NSF's Division of Environmental Biology and its Assembling the Tree of Life (AToL) program. Named Yanoco...Researchers develop technique for bacteria crowd control
...nly living bacteria respond to the pH stimulation, using this method can separate living and dead cells or bacteria with different motility. The device, capable to change the thickness of a film from 1mm to 1 micron (with accuracy of 5 percent) and control the position of electrodes, is intended to sepa...New study may show how to forestall a fatal, virus-caused immune-system meltdown
... and available now online, the scientists describe using a newly developed protein-scanning chip and a uniquely capable computer database to examine the activation and deactivation of more than a thousand proteins in cells from guinea pigs infected with two different strains of Pichinde virus. Guinea pigs ...Researchers urge monitoring of bone health during chemotherapy
...experimental mice, early clinical trials in humans using G-CSF with chemotherapy have so far shown no adverse effects on survival and no increase in bone metastasis. In fact, breast-cancer patients undergoing dose-dense chemotherapy with G-CSF support tend to have a longer disease-free period than those ge...Breakthrough in understanding type-2 diabetes as key genes identified
...s one of the first large studies to report results using the new genome-wide technology that governments and research charities have invested heavily in during the past few years. "Our research shows that this technology can generate big leaps forward. The task now is to study the genes identified in o...Exploring the molecular origin of blood clot flexibility
...pulling engineered strands of fibrinogen molecules using an atomic force microscope. This alpha-helical coiled-coil "spring" is a common motif in protein structure, first identified more than 50 years ago and so its stretchiness may have broader implications in biology and medicine. By understanding mec...Researchers create artificial enzyme that mimics the body's internal engine
...ed an artificial version of the enzyme active site using organic compounds as building materials. The imitation site, which involves an elaborate sequence of 32 chemical steps, was built from scratch and took several years to develop. The site contains the three active centers found in the naturally occ...DNA ends: Common tool, different job
...tudent and first author Hua Gao tested this model, using detailed biochemical experiments which revealed that Stn1 and Ten1 behave just like their counterparts in the conventional RPA complex. However, Stn1 and Ten1 have the same predilection for single-stranded telomeric DNA as Cdc13, thereby helping to e...Genes and biomarkers that allow doctors to choose the right therapy for the right patient
...eatments. Researchers at Vanderbilt University are using a biomarker library of peptides to determine wheth...ormed a genome-scale scan of two cancer cell lines using high-throughput RNAi, "interfering" RNA strands that bind to and knock out one gene individually, ac...Warming oceans threaten Antarctic glaciers
...c glaciers that pose a threat to future sea levels using satellite observations, according to a study published in the journal Science. Experts from the University of Edinburgh and University College London determined the effect that Antarctica and Greenland were having on global sea level in a comprehens...Biologists prove critical step in membrane fusion
...f the journal article in Developmental Cell. "When using the right cell ?the sea urchin egg ?the phenomenon is observable." "What we’ve found here with membrane fusion is that everything is set and ready for it to occur, to the point of sharing membranes," Wessel said. "So all that is needed is a puff o...Cancer tip -- Nanoparticles can damage DNA, increase cancer risk
... silica and C60 fullerene nanoparticle suspensions using the alkaline single-cell gel electrophoresis assay (Comet assay) to quantify breaks in single and double stranded DNA. The team chose these particular nanoparticle types because they are commonly used commercially ?in electronics, textiles and sport...Erectile dysfunction in diabetes is due to selective defect in the brain
...c rats after restoring the nNOS protein in the PVN using viral gene transfer. Results The researchers found that: when L-NMMA was used to block NO production in the PVN, NMDA mediated penile erectile responses were blunted NMDA-induced erections were significantly blunted in diabetic r...Researchers first to map gene that regulates adult stem cell growth
...s could open up new therapeutic strategies such as using stem cells for the treatment of other diseases and conditions such as liver disease, diabetes and central nervous system damage as a result of trauma or stroke. The researchers also are looking into the possible role the gene plays in transforming ...OHSU lab finds meth receptor that could lead to therapy
...lows biologists and chemists to work side-by-side, using their combined skills to identify drug targets and to design new drugs to treat diseases like drug addiction," said David Dawson, Ph.D., OHSU professor and chairman of physiology and pharmacology. "Chemical space ?that is, the number of possible drug...Gene therapy for blindness clears hurdle in mice
...ersions of the gene can be introduced into the eye using an apparently harmless virus to deliver the genetic material. "If we reduce the amount of protein formed by mutated rhodopsin, that may be sufficient to maintain vision in people who are affected by retinitis pigmentosa," Gorbatyuk said. "The seco...Global 'sunscreen' has likely thinned, report NASA scientists
...onducted the most comprehensive experiment to date using computer simulations of Earth's 20th-century clima...ded from the 1960s to 1990. Further simulations using one of the Goddard climate models revealed that aerosols blocking sunlight or trapping some of the s...