Divergent life history shapes gene expression in brains of salmon
...laces to oceans ? and then migrate heroically back upstream one to three years later to spawn ? and males of the same age known as "sneakers" that mature at greatly reduced size without leaving freshwater. "The finding that hundreds of the nearly 3,000 genes we studied were expressed differently in the brain...Bioinformatics reveals new gene regulation system
...que called phylogenetic footprinting to review the upstream DNA sequences of a group of genes that code for ri...evealed a conserved palindromic sequence occurring upstream of many ribonucleotide reductase (Nrd) genes. A genetic palindrome is a sequence of nucleotides on o...Natural Killers Could Lead to New Hepatitis Treatments
...show that NKT cells crawl along vessel walls, even upstream against blood flow. They halt only when they receive a chemical signal to unleash an immune-system assault on marauding microbes, other invaders or damaged tissue. The findings offer a new way of thinking about this important class of immune cell, w...Brain-mapping technique aids understanding of sleep, wakefulness
...nals. Researchers then track the tracer to map the upstream neurons. Dr. Yanagisawa and his colleagues are th...pothalamus. The researchers found that some of the upstream neurons in the anterior hypothalamus, known to be active only during sleep, send inhibitory signals ......and how this activation leads to activation of the upstream regulator of MK2, which is p38. Thus, while we now understand the biology of this inflammation, the details of the biochemistry still need to be worked out," he said. While the new knowledge of kaposin B's role will contribute to understanding how t......migrastatin analogues must be working on something upstream of those two important steps," Dr. Huang said. Dr. HuangÕs next important step is moving these analogues into clinical trials. "We're trying right now to get a company interested in this, especially because the mice used in our trial seemed to expe...