TEL2 gene cooperates with MYC gene to provoke B-cell lymphomas
... the MCB study, the investigators discovered that, unlike TEL1, TEL2 promotes cell multiplication, playing an indirect role in the development of B lymphoma. "TEL2 doesn't directly cause cancer," Grosveld said. "Instead, this gene promotes the development of lymphoma by enlarging the B lymphocyte populatio...Plant hemoglobins: Oxygen handlers critical for nitrogen fixation
...legumes through a process that is conceptually not unlike that undertaken by mammalian hemoglobins in facilitating oxygen transport and exchange in the blood. The most conspicuous plant hemoglobins are the symbiotic hemoglobins of legumes; these hemoglobins accumulate in root nodules and give these special...Scientists decipher genome of fungus that can cause life-threatening infections
...enestructures discovered in C. neoformans that are unlike those found inpreviously sequenced yeasts and are reminiscent of the genomes of morecomplex organisms. The study also catalogued, for the first time on agenome-wide scale in fungi, examples of "alternative splicing" and"antisense" transcripts, in whi...Female sex hormones play a vital role in defense against sexually transmitted diseases
...rpes virus, they received a vaccine Surprisingly, unlike in the first study, the progesterone-treated mice and the mice that received no hormones were the most protected. About half the mice in the combination hormone group were also protected and the estradiol-treated group was not at all protected. Simil...Gene therapy converts dead bone graft to new, living tissue
...e strength and support of the original bone. Bone, unlike any other tissue in the human body, can still perform one of its functions, structural support, even if all its cells are completely dead. A serious problem arises, however, when the bone wears over time. "Everyday activities cause microscopic fract......truction signal found in these proteins." However, unlike the other substrates recognized by Fbw7, T antigen is not destroyed by the cell. Drs. Clurman and Welcker suspect that by acting as a decoy and binding to Fbw7, T antigen protects cellular Fbw7 targets that facilitate viral replication and tumorigen...