Jumping gene could provide non-viral alternative for gene therapy
...lp correct muscular dystrophy. On the other hand, unlike retroviruses, transposons have to be coated with lipid to slip into cells. Although piggyBac is not as successful as the virus at integrating into DNA, "we could potentially make a hyperactive version of piggyBac, like they did for Sleeping Beauty...Solved: The mystery of flesh-eating bacteria's relentless attack
...crotizing fasciitis patient, the team noticed that unlike most Strep infections, in which white blood cells swarm invading bacteria to clear them from the body, few white blood cells appeared at the M14 infection site. A similar phenomenon had been observed in patients with necrotizing fasciitis but did not...Eat less, weigh more? Enzyme makes lean mice 'susceptible' to dietary fat
...o understand what the hypothalamus inputs are, but unlike the liver, where nearly the whole organ is involved in the same thing, the brain is very specialized and only a few neurons do very specific things," says Lane. The researchers hope to further understand how malonyl-CoA and CPT1c function to control...Why mice don't get cancer of the retina
...g the eye cancer retinoblastoma than mice because, unlike humans, mice can compensate for the loss of activity of a gene critical to normal retinal development , according to results of a study by investigators at St. Jude Children's Research Hospital. The study, published today in the open access journal B...Vaccine shown effective against chancroid
...making it an ever-changing target. But H. ducreyi, unlike other sexually transmitted bacteria, doesn't have such a protective mechanism. The current study and other studies suggest that developing a chancroid vaccine would be a relatively simple task, Elkins said. Commercial sex workers infected with cha...Large dinosaurs were extremely hot in their day, UF study finds
...erature changed dramatically through its lifespan, unlike any animals we know today," Gillooly said. "It increased by about 5 degrees Fahrenheit for species weighing about 661 pounds as adults and nearly 36 degrees for those reaching about 27 tons. This dramatic difference in body temperature between the la...... to be therapeutically effective. This is because, unlike non-regulatory T cells, Tregs do not proliferate in vitro when stimulated through either their TCR or IL-2 receptor alone. Now, in a study appearing online on August 17 in advance of print publication in the September issue of the Journal of Clini...How ancient whales lost their legs, got sleek and conquered the oceans
...es and dolphins were four-footed land animals, not unlike large dogs. They became the sleek swimmers we recognize today during the next 15 million years, losing their hind limbs in a dramatic example of evolutionary change. "We can see from fossils that whales clearly lived on land - they actually share a ...Bt cotton in China fails to reap profit after seven years
... Africa. When U.S. farmers plant Bt crops, they, unlike farmers in China, are required by contracts with seed producers to plant a refuge, a field of non-Bt crops, to maintain a bollworm population nearby to help prevent the pest from developing resistance to the Bt cotton. The pesticides used in these re...Insect predation sheds light on food web recovery after the dinosaur extinction
... tips, indicating a tropical rainforest completely unlike the other Paleocene floras. This site was on the ...of plants," said Wilf. "But the insect mines were unlike anywhere else in North America." The researchers found heavy and diverse insect damage; all abunda...Radiation-killed bacteria vaccine induces broad immune response in mice
...e from irradiated Listeria monocytogenes bacteria, unlike a vaccine made from heat-killed bacteria, provides protection against challenge with live Listeria. The irradiated bacteria also stimulated a protective response from immune system cells called T cells. Previously, only vaccines made from live, we...Purdue creates new low-cost system to detect bacteria
...nt costing more than $100,000, " Rajwa said. "And, unlike conventional systems, our method is 100 percent non-invasive, which means we can carry out the procedure without staining, manipulating or killing the biological samples. "The power of this technology is that it does not require complicated lab equ...Iron critical to ocean productivity, carbon uptake
...e additional pigments that fluoresce, or light up, unlike normal pigments, according to lead author Michael J. Behrenfeld, a research scientist in Oregon State University's Department of Botany and Plant Pathology. Unfortunately, he added, satellite imagery could not readily distinguish that difference. "I...Losing sleep undoes the rejuvenating effects new learning has on the brain
... a maze compared to their rested counterparts. And unlike the rats that got enough sleep, the sleep-restrict...to find the goal showed no increased neurogenesis, unlike their rested counterparts. This means that lack of sleep undoes the cell rejuvenation benefit that w...Anti-HIV drug has potential to prevent transmission in women
...t, tenofovir gel can prevent HIV from replicating, unlike other microbicides which have been designed to block HIV entry into cells, or have other mechanisms of action." If HIV cannot replicate, the authors infer, it is unlikely that it will be able to survive in the body long enough to cause infection. P...Alternatives to the use of nitrate as a fertiliser
...idised due to alteration produced in the enzymes), unlike that which occurs in the majority of these states. The activation of some antioxidant enzymes is reflection of stress that ammonium produces in plants. Moreover, this reaction can favour the growth of plants tolerant to ammonium in another situation ...Behavioral studies show UV contributes to marsupial color vision
... different types of color photoreceptor cones--but unlike primates, a component of marsupial color vision includes sensitivity to ultraviolet wavelengths. In the study, researchers employed behavioral tests to show that at least one type of marsupial uses its detection of UV light as part of its ability t...Microbes convert 'Styrofoam? into biodegradable plastic
...ases and oils, and can have a long shelf life. But unlike polystyrene, it readily breaks down in soil, water, septic systems and backyard composts. Worldwide, more than 14 million metric tons of polystyrene are produced annually, according to the U.S. Environmental Protection Agency. Most of this ends up i...UCLA imaging study of children with autism finds broken mirror neuron system
...utism Diagnostic Interview). The study shows that unlike typically developing children, children with autism have virtually no activity in the pars opercularis of the inferior frontal gyrus, identified by previous research as a key part of the mirror neuron system. Importantly, the level of mirror neuron ......me uses a powerful centrin-based mechanism that is unlike any complex actin or microtubule-based cellular engine, says France. "This leads us closer to understanding two things: how cells use centrin-based engines to generate enormous forces and how we can possibly reconstruct centrin-based materials and de...