Discovering the first steps in transcription-coupled repair
...In addition, there were hints for an important but unknown role for the protein XPG in transcription-coupled repair. In both humans and mice, when gene mutations produce a severely truncated form of XPG, the result is profound Cockayne Syndrome and very early death. Through an ingenious series of biochemica...Team led by Carnegie Mellon University scientist finds first evidence of a living memory trace
...g brain that occurs after exposure to a previously unknown stimulus." "Future investigations along the lines... developed after a single exposure to a previously unknown stimulus, so that there is no context," said Galán. "All previous studies in this field have observe...Deep treasure to be found in Oculina Bank
... the reefs and likely identification of previously unknown coral features. "Understanding the extent of the reefs and where the most important habitats are will help researchers and managers determine those areas that need the greatest protection, and those that might require less protection, " says Reed...Double trouble: Cells with duplicate genomes can trigger tumors
... by random errors in cell division that occur with unknown frequency. The generation of these genetically unstable cells appears to be a "pathway for generating a tumor," says David Pellman, MD, a pediatric oncologist at Dana-Farber and at Children's Hospital Boston. He is the senior author on a report in th...Bacteria which sense the Earth's magnetic field
...efore. Amazingly, the scientists saw a previously unknown filamentous structure along the magnetosome chain of the wild type cells. It resembled a similar structure which structural biologists from Martinsried had already imaged in three dimensions in other cells. This shed light on the crux of the problem ...Plant gene related to cancer treatment may foster new oncology drugs
.... Results of the two studies suggest a previously unknown relationship between two protein families involved in this process, he said. Working together, the proteins apparently move molecules of the plant growth hormone auxin through cell walls. In humans, related proteins rid cells of toxins such as cancer...New genetic test can detect clam disease
...aquaculture operations. QPX - for quahog parasite unknown - is a single-celled organism related to slime mold. It was first detected in 1995 in Provincetown, MA and spread to nearby clam beds, killing nine of ten clams in many of the beds. The disease spreads from clam to clam, infecting the clam by secreti...Restaurant seafood prices since 1850s help plot marine harvests through history
...bout ocean life in the past, and delineate what is unknown but discoverable, and what may be unknowable about the world's oceans. Fish: Food for all Ages "Fish has been part of peoples' diets since humans first walked the earth and remains a vital item in the daily diet of millions worldwide," says Danish ...Emerging staph strains found to be increasingly deadly and deceptive
...y, and colleagues plan to determine if some of the unknown genes help promote disease. If they can learn which genes control the ability of S. aureus to evade and destroy neutrophils, their work could lead to new medical treatments. "Each day physicians around the world are stymied by the inability to effec...New study to explore cellular circuitry
...ble ways, we can begin to identify the function of unknown cellular players based on their neighbors and associates," said Eric M. Phizicky, Ph.D., professor of Biochemistry and Biophysics at the medical center. "That puts us within reach of a completed diagram and the ability to re-wire cells in the treat...Biologists Crack Genetic Code for Specialized Spider Silk
...ns. “Most cases of CVID and IgA deficiency are of unknown cause,?notes Josiah Wedgwood, M.D., Ph.D., of the Clinical Immunology Branch of the National Institute of Allergy and Infectious Diseases (NIAID), the component of the National Institutes of Health that funded the study. “To find a specific molecular...Agreement will speed research on microbicides for women
...ns. “Most cases of CVID and IgA deficiency are of unknown cause,?notes Josiah Wedgwood, M.D., Ph.D., of the Clinical Immunology Branch of the National Institute of Allergy and Infectious Diseases (NIAID), the component of the National Institutes of Health that funded the study. “To find a specific molecular...Defective Gene Linked to Two Inherited Immune Deficiencies
...ns. “Most cases of CVID and IgA deficiency are of unknown cause,?notes Josiah Wedgwood, M.D., Ph.D., of the Clinical Immunology Branch of the National Institute of Allergy and Infectious Diseases (NIAID), the component of the National Institutes of Health that funded the study. “To find a specific molecular...Newly recognized gene mutation may reduce seeds, resurrect plants
...ed RESURRECTION1 (RST1), has revealed a previously unknown genetic connection between lipid development and embryo development in plants, said Matthew Jenks, lead author of the study and a Purdue plant physiologist. Lipids play a role in preventing plant dehydration in forming cells' membranes, in molecular...UW scientists report a new method to speed bird flu vaccine production
...production because they are not known to carry any unknown infectious agents and do not cause tumors. According to Kawaoka, "application of the new system may be especially advantageous in situations of outbreaks of highly pathogenic avian influenza viruses." When a new strain of highly virulent influenza ...DDT-resistant insects have additional genetic advantage that helps resistance spread
...DDT resistant the female flies are passing on some unknown advantage to their progeny, presumably associated with the single metabolic enzyme (cytochrome P450) that they over express.'' "These results are important for the use of any drug, pesticide or antibiotic as they suggest that resistance will not alw...Neurotransmitters signal aggressive cancer, offer potential for early diagnosis
...itter and the other a plant growth hormone with an unknown function in animals. Furthermore, the researchers found that the tumors made GABA using a different set of biochemical reactions than normal. Key enzymes involved in the production of these compounds were switched on in poor prognosis malignant metas...Rutgers to lead $52.7 million protein research program
... majority of the proteins coded by the genome have unknown functions and unknown structure. For the past five years, Montelione and his consortium partners, including researchers a...Fish and chips: A fast track to understanding blood development
...n focused on a group of 61 of these genes that had unknown roles in the function of blood stem cells. Using zebrafish, a small fish that develops red blood cells in a way similar to humans, they "turned off" these genes in the fish embryos and watched to see if the blood formed normally. They found that dis...