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Tag: "undetectable" at biology news

454 sequencing identifies HIV drug resistance at early stage

...’s Genome Sequencer™ system to identify previously undetectable rare drug resistant HIV variants in samples from a...s previously thought. Most low level mutations are undetectable by current resistance testing methods that are used in the clinic. The additional low abundant resis...

Resistant HIV quickly hides in infants' cells

...ut levels of resistant virus declined over time to undetectable levels. In the current study, however, researchers found these resistant viruses quickly took up residence in inactive T cells, from where they could later launch an attack that NNRTIs could not stop. The news was not all bad: a different class of a...

Genetic pathways to curable and incurable forms of pancreatic cancer identified

...reatic epithelial neoplasms, are tiny enough to be undetectable until the disease has progressed to the point where survival is almost nil. Moreover, these cells appear to be highly sensitive to the tumor-promoting properties of TGFb and thereby manifest a more aggressive behavior. "With accurate animal models...

Newly identified biomarker detects and regulates spread of brain tumors

... absent in the central nervous system (CNS) and is undetectable in cerebral spinal fluid (CSF), unless malignant astrocytomas--the most common form of intracranial tumors--are present in the CNS. The CSF is a liquid that bathes the brain and acts as a reservoir, which can be sampled for analysis of proteins secre...

Human testis harbors HIV-1 in resident immune cells

...rapeutic levels. Thus, although HAART may achieve undetectable virus levels in the blood, virus replication in the testis may permit continued spread of the virus. Finally, with HIV infection continuing to rise, the development of anti-retroviral therapy that effectively targets all sources of HIV, including...

Novel therapy combinations gain ground in treating hepatitis

...ive assay after just eight days. All patients had undetectable HCV RNA by the end of 28 days. No patients experi...tiviral effects of VX-950. All subjects achieving undetectable HCV RNA within 28 days of treatment is an unprecedented result with an investigational agent," said ...

CHAVI announces international search for genes affecting HIV response

...ome people naturally hold the virus down to almost undetectable levels while others lose control of it quickly." The newly organized group, called EuroCHAVI, will recruit 600 patients from nine cohorts. "This will be is the largest cohort assembled for large-scale analysis of genetic differences among HIV-infect...

Protein found to control tumor growth in certain breast cancers

...minished rapidly in these mice, becoming virtually undetectable by the end of the experiment. In MCF-7 cells where Nod1 was absent, the tumors flourished. In addition, there was an increased sensitivity to estrogen-induced cell proliferation and a failure to undergo Nod1-dependent apoptosis in vitro. Takin...

Chemical warfare agent detection technology used to treat lung disease

...hat one day we will be able to detect a previously undetectable tumour metabolising inside a human lung simply by asking a patient to breathe into a device like this. For now our aim to use the microDMx sensor to develop better instruments which will improve patient care and treatment. "The potential is such tha...

The reason why antiviral therapy can't annihilate HIV infection, and what to do about it

...p to 9.1 years of effective antiviral therapy with undetectable levels of HIV in their plasma. Their data also suggest that latently infected, resting CD4+ T cells may become reactivated, most likely as a result of normal immunologic responses to various antigens and cytokines. In turn, virions released during ...

Image of myosin-actin interaction revealed in cover story of Molecular Cell

... to familial hypertrophic cardiomyopathy (FHC), an undetectable condition resulting in death by sudden cardiac arrest in otherwise healthy young adults. Contributors to this work include: Niels Volkmann, Ph.D., assistant professor and first author on this publication, Dorit Hanein, Ph.D., associate professor, Ho...

New imaging technology shown to detect pancreatic inflammation in type 1 diabetes

...ed a new imaging technique to reveal the otherwise undetectable inflammation of pancreatic islets in recently diagnosed diabetic mice. As T lymphocytes invade the pancreas, blood vessels swell, become more permeable, and leak fluid ?as well as small molecules carried in the fluid ?into surrounding tissues. In pre...

Newest HIV drugs should be used with FUZEON(R)

...s facing resistance their best chance of achieving undetectable viral load ?the optimal treatment goal for all peo...atients facing HIV resistance and failing to reach undetectable viral load." Studies presented this week show that when FUZEON was given in combination with the no...

Newer imaging techniques may lead to over-treatment

...nefit ratio of therapy in patients with previously undetectable small clots in the peripheral pulmonary vasculature," he added. Dr. Prologo recommends a large-scale prospective randomized study to determine if patients with small clots need to undergo anticoagulation treatment. "Today a great many more patients ...

Jefferson Virologists Coax HIV Out of Hiding

...s instead goes intohiding, dormant and practically undetectable in the body ?andimpervious to attack. While HAART ...ctedpatients who had been taking HAART and who had undetectable levels ofvirus. Using a special technique, they screened the cells with severaldifferent drugs to de...

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