Computational Method Speeds Mapping of Cell Signaling Networks
... This application would be particularly useful for understanding disease states where signaling malfunction plays a prominent role, including cancer and autoimmunity. Until now, the large amounts of data the technique requires prevented its application to protein networks. Being able to monitor multiple component...New insight into regulation of blood stem cells
Scientists have made a significant advance toward understanding the regulation of blood stem cells and the complex, lifelong process of blood cell formation. A research study published in the February issue of Developmental Cell expands on previous studies by using adult animals to examine the role of a key gene ...Researchers rein in regulatory RNAs
...rs expect that these results will lead to a better understanding of roles of non-coding RNAs in gene regulation. ...Birds brains reveal source of songs
...n Research at MIT now have come one step closer to understanding that process. They've shown for the first time how a particular brain region in birds serves as the source of vocal creativity. "It's an extraordinary finding," says Sarah Bottjer of the University of Southern California. "Here's an organism that en...Chemicals in tattoo inks need closer scrutiny
...young people, it is vital that we develop a better understanding of this form of self expression." The new researc...eactions might be, and the only way to gain better understanding is to know what chemicals make up the inks, the researchers say. Finley-Jones and Wagner expect that...Navigating an integrated yeast network
...ast cell in a simple graphical form, enhancing our understanding of how the networks of interaction by which components of a cell influence one another. New research published in the Open Access journal Journal of Biology shows that such maps can also reveal cryptic interactions and enable accurate predictions abo...Disease diagnosis, biodefense among UH chemical research projects
...His group's poster presents progress toward better understanding of the chemical and physical driving forces of carbohydrate-protein interactions that are important in biological systems. # Roman S. Czernuszewicz, associate professor of chemistry, will present research on "Resonance Raman spectroscopy of nitropho...Scientists identify genetic pathways essential to RNA interference
...sion in cancer." The researchers note that better understanding the mechanisms underlying RNAi could help transform what has been a research tool into a powerful therapeutic tool. Although the process has worked well in studies of cultured human cells, it has not yet been effective for experimentally suppressing ...Brain-mapping technique aids understanding of sleep, wakefulness
...r neurons in the brain is an important step toward understanding how and why we sleep. Mapping the neurons to which orexin neurons send signals has been relatively easy, Dr. Yanagisawa said, but determining which neurons send signals to orexin neurons has been a challenge. A brain-mapping technique developed rece...Small species back-up giant marsupial climate change extinction claim
...g fossil deposits are providing us with the key to understanding Australia's past, something integral when developing long term strategies for a sustainable future." ...White Blood Cell 'Waste Disposal' System Plays Critical Regulatory Role
... actively linked to neutrophil production. A clear understanding of the processes that control neutrophil turnover may contribute to the development of future therapeutics for conditions characterized by abnormal numbers of these critical immune cells. Human neutrophils are white blood cells that are constantly b...Same-Sex Mating Discovered in a Toxic Fungus
...eatening in humans, and the findings might improve understanding of the fungal biology that underlies the infectiou...trategy may also contribute to scientists' general understanding of the conditions that favor evolutionary transitions between self-fertilization and sexual reproduc...Brain Scans Reveal How Gene May Boost Schizophrenia Risk
...del," said Berman. "The study is important for our understanding of schizophrenia because it clarifies the neural mechanism for a well-established risk gene." Also participating in the NIMH brain imaging study were: Dr. Daniel Weinberger, Philip Kohn, Dr. Bhaskar Kolachana, Shane Kippenhan, NIMH; Dr. Aideen McIne...Researchers unlock mechanism creating jigsaw puzzle-like plant cells
...talk that coordinates cells into tissues, a deeper understanding of how plant cells chemically talk to each other to grow or recede in an ordered way remains unclear. ...New understanding of DNA repair may pave way to cancer treatments
...laboratory has been studying ATF2 with the goal of understanding its role in regulation of cell cycle and programmed cell death. These studies evolved from the finding that ATF2 has an important role in the development and progression of melanoma tumors. Inhibition of ATF2 was found to sensitize melanoma to variou...Cerebral navigation: How do nerve fibers know what direction to grow in?
...ance. "Understanding these pathways could help in understanding the process of nerve regeneration," says Greenberg, who is also Professor of Neurology and Neurobiology at Harvard Medical School. "The mechanisms we've uncovered could provide opportunities for the development of therapies for spinal cord injury, ta...Study: 'homemade' gene expression technology unreliable
...ion in technology that is hoped rapidly to advance understanding of biological mechanisms and methods to assess the actions and effects of drugs and chemicals," said Spencer, who estimates there are "hundreds, if not thousands" of laboratories around the country using DNA microarrays. Microarray platforms came in...NIH Researchers Discover How Insulin Allows Entry of Glucose Into Cells
...es. “This finding provides useful information for understanding disorders in which cells have difficulty using insulin, such as insulin resistance and type 2 diabetes,?said NICHD Director Duane Alexander, M.D. Glucose, a simple sugar, is a nutrient that cells need to survive, explained the study’s corresponding ...New tumor-suppressor gene discovered
...e of the journal Cell. "This discovery extends our understanding of how tissue growth is controlled both during nor... this gene may have important implications for the understanding and treatment of human cancers," says research leader Zhi-Chun Lai, associate professor of biology, ...Grasping metaphors: UC San Diego research ties brain area to figures of speech
...ut also to the supramarginal gyrus, was abysmal at understanding action metaphors such as "grasping an idea" or "putting your finger on the main argument." ...