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Tag: "underlying" at biology news

No small feat: First ever gene therapy success for muscular dystrophy achieved

...nrelated to laminin alpha-2. Unless we address the underlying cause of congenital muscular dystrophy we're not likely to be able to completely arrest or cure CMD," added Chungping Qiao, M.D., Ph.D., the study's first author and a research associate fellow in Dr. Xiao's lab. Future directions for research inclu...

Scientists discover gene that controls speed of tuberculosis development

...S) this week provides a new view of the mechanisms underlying the development of tuberculosis and may contribute to public health efforts aimed at containing the disease. "About one-third of the world's population is infected by Mycobacterium tuberculosis--the bacteria responsible for tuberculosis," says Dr. E...

Biota makes major antiviral discovery

...nts, such as children, the elderly and people with underlying respiratory conditions. Latest results in two animal models also demonstrate that Biota's new RSV antivirals are effective when administered orally. This should allow the product to be developed in a convenient oral formulation, such as a tablet or ...

Change in gene may be underlying molecular defect in some colorectal cancers

...defect", cells that appear normal but that have an underlying molecular defect. The molecular basis for the field defect is easy to understand when tumors develop from cells that all have similar genetic abnormalities, such as those that occur in patients who are genetically predisposed to a cancer or those who...

Digging in the dirt for life's biochemical foundations

...re. "The really fascinating part is the mechanism underlying the transfer process," says Maria Harrison, a plant biologist at Cornell University's Boyce Thompson Institute and an expert on fungus-facilitated movement of other soil nutrients into plant roots. "Dr. Shachar-Hill and his colleagues were able to sh...

Envisat and ERS-2 reveal hidden side of Hurricane Rita

...made complementary observations of the hurricane's underlying wind fields using its radar scatterometer. This instrument works by firing a trio of high-frequency radar beams down to the ocean, then analysing the pattern of backscatter reflected up again. Wind-driven ripples on the ocean surface modify the rad...

A novel method to measure circadian cycles

...dian differences (and thereby hope to rout out the underlying genetic causes), scientists have had to rely on prolonged behavioural observation. To screen for and identify circadian rhythm variations in humans, the required period of lengthy observation is prohibitively costly and labor intensive. Circumvent...

Gene discovery sheds light on causes of rare disease, cancer

...other bacteria. Cossart and Veiga investigated the underlying machinery behind this uncommon invasion strategy, which they knew depended on an interaction between a protein on the surface of the bacteria, known as InlB, and a protein called Met on the surface of the cell it was invading. They discovered that...

Hide and seek: Researchers discover a new way for infectious bacteria to enter cells

...other bacteria. Cossart and Veiga investigated the underlying machinery behind this uncommon invasion strategy, which they knew depended on an interaction between a protein on the surface of the bacteria, known as InlB, and a protein called Met on the surface of the cell it was invading. They discovered that...

Malfunctioning bone marrow cells sabotage nerve cells in diabetes

...rward to pursuing this possibility. Discovering an underlying cause of diabetic neuropathy may enable us to design treatment strategies to prevent this complication in the future," concluded Chan. ...

Scientists devise way to measure RNA synthesis on the fly in a live cell

...se techniques, "one cannot detect in real time the underlying dynamics of RNA synthesis associated with cellular activities," he said. But the scientists in his laboratory have found a way around this with a technique called fluorescence correlation spectroscopy (FCS). First, they use an RNA molecule that will...

Investigating 'brain shrinkage' in alcoholics

... objective was to better understand the mechanisms underlying alcohol's damage, with the ultimate goal of identi...esearch allows for an unprecedented examination of underlying mechanisms of damage. "Alcohol dependence follows a longitudinal course," explained Harper, "from i...

Gap-climbing fruit flies reveal components of goal-driven behaviors

...ill straighten her back, and tiptoe. Studying the underlying control principles and neuronal circuits in invert...ve neurogenetic techniques for the analysis of the underlying motor-control system, Pick and Strauss showed that in order to reach a goal, flies compose complex m...

Pinpointing a culprit molecule in Alzheimer's disease

...s why mice engineered to have the abnormal protein underlying the disease in humans show little pathology of the disease. Specifically, such mice are genetically altered to overproduce mutant human amyloid precursor protein (APP). It is this protein that, when clipped by enzymes, produces the amyloid beta (Ab) ...

Plankton can run, but can't hide from basking sharks

...ies in water temperature. Although the mechanisms underlying this behaviour are unclear, the results indicate that the sharks are responding to changes in vertical migration by the zooplankton. Zooplankton have evolved a range of behaviours to try and avoid being eaten, sometimes staying at greater depths duri...

Attacks of King George III's madness linked to key metabolism molecule

...op more specific treatments now that the mechanism underlying the symptoms of porphyria is better understood. ...

Major advance made on DNA structure

...ultimately determine the physical structure of the underlying DNA for all different types of sequences. Another important part of this study is the finding that the process of DNA crystallization does not distort its structure. "Essentially, this is a proof of concept, a demonstration that this approach to stu...

Field of beams - Novel system uses polarized light pulses to reveal crop health

...els can be useful in two ways: they can reveal the underlying characteristics of an infection and they can allow the comparison of alternative control measures. Often, however, such models make implicit assumptions that may systematically bias their predictions, say researchers at the University of Georgia. In...

Inhaling large amounts of salt can cause hypertension

...els can be useful in two ways: they can reveal the underlying characteristics of an infection and they can allow the comparison of alternative control measures. Often, however, such models make implicit assumptions that may systematically bias their predictions, say researchers at the University of Georgia. In...

Understanding biases in epidemic models important when making public health predictions

...els can be useful in two ways: they can reveal the underlying characteristics of an infection and they can allow the comparison of alternative control measures. Often, however, such models make implicit assumptions that may systematically bias their predictions, say researchers at the University of Georgia. In...

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