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Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas

Scientists at Joslin Diabetes Center have discovered one reason why infants with low birth weight have a high potential of developing type 2 diabetes later in life. In studies of mice, the researchers found that poor prenatal nutrition impairs the pancreas's ability to later secrete enough insulin in response to blood glucose. .. "The bottom line is that if you don't have delivery of enough nutri...

Researchers Uncover Key Step In Manufacture of Memory Protein

A cellular enzyme appears to play a crucial role in the manufacture of a protein needed for long-term memory, according to a team of researchers led by scientists at the National Institute of Child Health and Human Development of the National Institutes of Health. .. . “Understanding how BDNF is made may help us to...

Automatic extraction of gene/protein biological functions from biomedical text

With the rapid advancement of biomedical science and the development of high-throughput analysis methods, the extraction of various types of information from biomedical text has become critical. Since automatic functional annotations of genes are quite useful for interpreting large amounts of high-throughput data efficiently, the demand for automatic extraction of information related to gene func...

New research questions basic tenet of neuron function

New findings by researchers at UT Southwestern Medical Center challenge one of the established views of how nerve cells communicate with one another. .. .. It is known that synaptic ves...

DNA Recombination and Repair—A New Twist to RecA Function

Molecular motors harness the energy of ATP (or GTP, a related energy currency) and transform it into mechanical force. Well-known examples of motors include myosin and dynein, proteins that use ATP to ferry intracellular cargo along fibers made of actin or tubulin proteins. The ATP-dependent assembly of actin or tubulin fibers itself can work as a motor: for instance, the march of white blood cel...

Affymetrix and the Karolinska Institutet Announce Translational Medicine Strategic Alliance

Affymetrix Inc. (Nasdaq: AFFX - News) and Karolinska Institutet announced today that they have entered into a strategic alliance designed to improve healthcare by accelerating the translation of basic genetic research into tools for better diagnosis, prognosis, and treatment. .. During the next five years the projects include genetic analyses and measurement of gene expression in patients with at...

Affymetrix and Stratagene Announce Strategic Software Alliance

. In April 2005, Affymetrix will make ArrayAssist Li...

Wiley announces publication of Databasing the Brain

Understanding the structure, function, and development of the brain in health and disease represents one of the great scientific challenges of our time. The emerging field of neuroinformatics integrates neuroscience with informatics to create unique databases and analytical tools for the large variety of neuroscience data types, applying them to brain research and linking them with databases with...

Kinovate Life Sciences Launches Nittophase?High Performance Solid Support For Oligonucleatide Synthesis

Kinovate Life Sciences, Inc, a provider of tools for oligonucleotide synthesis and gene delivery, announced today that it will officially launch its new NittoPhase?solid support for oligonucleotide synthesis at the TIDES meeting commencing in Boston on May 1st. The joint development of this solid phase support product was announced on November 8th, 2004 by Kinovate’s sole shareholder, Nitto Denko...

Vascular structure and function improve with diet and exercise

Some structural and functional measures of cardiovascular disease risk may improve by the eighth week of a diet and exercise regimen, according to a study presented today at the American Heart Association's Sixth Annual Conference on Arteriosclerosis, Thrombosis and Vascular Biology. . "Our lifestyle management program appears to improve the health of the vasculature, so it might lower the risk o...

Towards precise classification of cancers based on robust gene functional expression profiles

Chemists say they have identified a gene that appears to play a key role in the development of type 1 diabetes, also known as insulin-dependent or juvenile diabetes, a disease that affects about one million people in the U.S. and is on the rise worldwide. They described their findings, which they say could lead to new drug interventions and possibly gene therapy, today at the 229th national meeti...

Nonlinear Dynamics announces more details of its global partnership with PerkinElmer

Nonlinear Dynamics Ltd, a leading provider of bioinformatics solutions, today announced further details of its global OEM partnership with PerkinElmer, Inc. (NYSE: PKI), a leading provider of drug discovery, life science research and analytical solutions. . As detailed in a press release issued last week, PerkinElmer will distribute Nonlinear's full range of 1D, 2D and array software. However the...

UCLA launches $20 million stem cell institute to investigate HIV, cancer and neurological disorders

Experts in bioengineering, imaging, molecular genetics, immunology, ethics, hematology/oncology and cellular biology to collaborate on Proposition 71 research .. . "As one of the world's leading research universities, UCLA has long been engaged in adult and embryonic stem ce...

Researchers uncover sequence of major rice pathogen

In a genomics milestone, an international consortium of researchers has for the first time lifted the veil from a fungal plant pathogen by sequencing the genome ?or set of all genes ?of the most destructive enemy of rice: Magnaporthe grisea, the fungus that causes rice blast disease. . .. It is estimated that rice blast, t...

FDA Announces Series of Changes to the Class of Marketed Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

The Food and Drug Administration (FDA) today announced a series of important changes pertaining to the marketing of the non-steroidal anti-inflammatory class of drugs, including COX-2 selective and prescription and non-prescription (over-the-counter (OTC)) non-selective NSAID medications. A list of these products is available on the Internet at http://www.fda.gov/cder/drug/infopage/cox2/default.h...

UNC launches study of liver injury caused by drugs

The University of North Carolina at Chapel Hill is one of five clinical centers nationwide to receive funds from the National Institutes of Health to study why good medications are sometimes bad for the liver. .. . Funded by the National Institute of Diabetes and Digestive and Kidney Diseases, DILIN will be the first large-scale inves...

Roche clinical trial registry and results database launched

Within only three months after deciding to create an electronic database, Roche is launching a public clinical trial registry and results database using an independent host, CenterWatch. On www.roche-trials.com information on Roche’s clinical trials can be accessed by anyone, anywhere, with no password restrictions. This site is designed to give patients and healthcare providers ready access to i...

First technology to remove prions that cause vCJD from blood launched

The risk of receiving blood contaminated with variant Creutzfeldt-Jakob (vCJD) prions may no longer be a concern for the thousands of people who require a transfusion. Pall Corporation (NYSE: PLL) announced today the Council of Europe (CE) marking of its Leukotrap® Affinity Prion Reduction Filter System. It is the first and only technology that removes infectious prions that may be the causative...

Study uncovers bacteria's worst enemy

University of California scientists working at Los Alamos National Laboratory have found that the successful use of bacteria to remediate environmental contamination from nuclear waste and processing activities may depend more upon how resistant the bacteria are to chemicals than to how tolerant they are to radioactivity. The results of a recent Laboratory study may help make bacterial bioremedia...

Molecular fossils uncover link between viruses and the immune system

Researchers from the Viikki Biocenter, University of Helsinki, show that atomic structures can reveal evolutionary history of viruses in a similar fashion as fossils did for the dinosaurs and reptiles. Their article is published in the April 15 issue of Molecular Cell. . .. These results are an outcome of recent advances in structural bi...

Unchecked DNA replication drives earliest steps toward cancer

Although not widely appreciated as a disease of the genes, cancer is always rooted in genetic errors or problems in gene regulation. Scientists have identified some of the first genetic triggers for cancer as mutations in specific oncogenes or tumor suppressor genes. Full-blown tumors and metastatic cancers, however, often exhibit many genetic mutations, sometimes dozens in a given tumor. An impo...

Affymetrix Launches New Globin-Reduction Kits and Protocol Developed with PreAnalytiX

Affymetrix Inc. (Nasdaq: AFFX), announced today the launch of the new GeneChip(R) Globin-Reduction kits and associated protocol developed in conjunction with PreAnalytiX -- a joint venture between QIAGEN N.V. (Nasdaq: QGEN; Frankfurt, Prime Standard: QIA) and BD (Becton, Dickinson and Company). The new kits optimize the PreAnalytiX PAXgene(TM) Blood RNA System for use with Affymetrix GeneChip tec...

Software Tool for Converting Scientific Text into a Database of Functional Relationships

Ariadne Genomics, Inc. today announced the launch of MedScan?Text-to-Knowledge Suite 2.0, a Natural Language Processing-based tool for automated extraction of biological facts from scientific literature, MEDLINE abstracts, and other text sources. A demo version of MedScan is available at www.ariadnegenomics.com. . MedScan leverages hand-crafted dictionaries of protein and chemical names, and prec...

Ariadne Genomics Announces the Release of PathwayStudio?Central, Client-Server Software for Biological Pathway Analysis

Ariadne Genomics, Inc. today announced the release of PathwayStudio?Central, client-server software for visualization and analysis of biological pathways and gene regulation networks for bio-medical research labs, biotechnology and pharmaceutical companies. PathwayStudio?Central is available for a free 20 day trial at www.ariadnegenomics.com. . PathwayStudio?Central builds pathways from microarra...

PHACCS, an online tool for estimating the structure and diversity of uncultured viral communities using metagenomic information

In the March 3 issue of Nature, Johns Hopkins researchers report that two proteins best known for very different activities actually come together to turn the liver into a sugar-producing factory when food is scarce. Because the liver's production of sugar is a damaging problem in people with diabetes, the proteins' interaction might be a target for future drugs to fight the disease, the research...

Next Generation Body Scanner Launched By The University Of Manchester

The first `next generation' MRI (magnetic resonance imaging) body scanner in the world will be officially launched at Hope Hospital later this week (Friday 18 th February). .. .. The state-of-the-art technology involved will revolutionise the way scanning takes place and means that higher quality scans can be carried out at a much faster speed than ever before. The scanner will enable researchers...

Embryonic Stem Cells Treated With Growth Factor Reverse Hemophilia In Mice: UNC Researchers

University of North Carolina at Chapel Hill researchers have made a discovery that may have implications for the treatment of liver-based genetic defects such as hemophilia A and B in humans. .. . The genetically altered mice lack the clotting substance factor IX, which in humans res...

DOE JGI launches IMG public online microbial genome data clearinghouse

As the microbial world comes to light through DNA sequencing, the new Integrated Microbial Genomes (IMG) data management system of the U.S. Department of Energy (DOE) Joint Genome Institute (JGI) will deliver valuable information for the benefit of the global research community. .. "The IMG system is an essential enhancement to the computational toolkit supported by DOE," said Dr. Aristides A. Pa...

Breakthrough System for Understanding Ocean Plant Life Announced

Sixty million people in 36 countries of sub-Saharan Africa are threatened daily by a deadly parasitic disease known as African sleeping sickness. The disease is caused by organisms called trypanosomes, which are spread by the tsetse fly. African sleeping sickness affects approximately 500,000 people in sub-Saharan Africa, a quarter of whom will die this year. Because the trypanosome has an except...

Function of new cancer genes discovered

Dutch researcher Sebastian Nijman has discovered new genes which are involved in the development of cancer. The results of his research have led to a new treatment for patients with an inherited form of cancer, cylindromatosis. .. . People with this disease have a mutated form of the protein CYLD. Nijman and his colleagues used genetic screens to discover the molecular mechanism underlying cylind...

Research Reveals Functions Of Harmful Shellfish Pathogens

Providing safer shellfish is the goal of Agricultural Research Service (ARS) scientists who are studying the means by which pathogenic bacteria enter shellfish. . .. ARS scientists at the Microbial Safety of Aquaculture Products Center of Excellence in Dover, Del., are studying these bacteria with the goal of keepi...

Major new UNC-based drinking water study suggests pregnancy fears may be overstated

Fears that chemical byproducts resulting from purifying drinking water with chlorine boost the chances that pregnant women will miscarry were not supported by the results of a major new study. If such threats exist at all, which is uncertain, they likely are modest, it concludes. . .. "We think our n...

Unique library of plant genes germinates, takes root at UNC

The University of North Carolina at Chapel Hill's newest "library" is not the kind that will entice an average book lover, but it eventually will please thousands of plant scientists around the world. Through such researchers' work, it will undoubtedly contribute to improving crops that humans around the planet depend on every day, its developers say. . .. "But it's also much more t...

Researchers reveal secret of key protein in brain and heart function

Brown University biologists have solved the structure of a critical piece of synapse-associated protein 97 (SAP97) found in abundance in the heart and head, where it is believed to play a role in everything from cardiac contractions to memory creation. Results are published in The Journal of Biological Chemistry. . Dale Mierke, associate professor of medical science at Brown, said that knowing ho...

IMF Launches World’s First DNA Database for Myeloma Patients

A biologist at Washington University in St. Louis has shown that for some fish species, females prefer males with larger sexual organs, and actually choose them for mating. That does not exclude males with an average-sized sex organ, called a gonopodium. These fish out-compete the larger-endowed males in a predator-laden environment because they have a faster burst speed than the males with large...

UNC plant researchers discover proteins interact to form hair-trigger protection against invaders

Experimenting with Arabidopsis, a fast-growing cousin of the humble mustard plant, scientists at the University of North Carolina at Chapel Hill got a big surprise while investigating how plants respond to attacks from disease organisms such as bacteria and viruses. . "Contrary to what we thought we'd find, our experiments showed that at least three different proteins work in concert with one ano...

By creating molecular bridge, scientists change function of a protein

By designing a molecular bridge, scientists at the University of Illinois at Urbana-Champaign have forged a successful pathway through a complex ocean of barriers: They've changed the function of a protein using a co-evolution approach. .. . In doing so, Zhao and Chen skirted the two time-and-la...

Invitrogen Launches i-Path -- A Unique Systems Biology Platform at BIO 2005

Scientists in Belgium have discovered how to clone human embryos from eggs that have been matured in the laboratory. Their discovery should make it easier for scientists to create embryonic stem cell lines from cloned embryos and develop them to provide eggs and sperm for infertile couples, the 21st annual conference of the European Society of Human Reproduction and Embryology heard today (Monday...

New defibrillator signals doctor of patient's irregular heartbeat or device malfunction

Loyola first in U.S. to implant new FDA-approved device .. . When a patient's status changes, a built-in microchip of Biotronik's Lumos DR-T implantable cardioverter defibrillator (ICD) sends a signal to a satellite via a small transmitter that can be p...

'Punctuated' evolution in the human genome

Researchers report today that regions of the human genome have been hotspots for acquiring duplicated DNA sequences ?but only at specific time-points during evolution. It appears that long periods of genomic stasis, at least with regard to the accretion of duplicated DNA fragments, are "punctuated" by relatively brief episodes of duplicative activity. This is the first time that such temporal bia...
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Breaking Medicine News(10 mins):Health News:Columbia University College of Dental Medicine receives diversity award 2Health News:Columbia University College of Dental Medicine receives diversity award 3Health News:Columbia University College of Dental Medicine receives diversity award 4Health News:Getting the jump on competitors: QUT study 2Health News:Chemotherapy and SABR consecutively may be promising treatment option for advanced pancreatic cancer 2Health News:Chemotherapy and SABR consecutively may be promising treatment option for advanced pancreatic cancer 3Health News:Chemotherapy and SABR consecutively may be promising treatment option for advanced pancreatic cancer 4Health News:ESMO 2014 Congress Preview 2
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