ultimate 2 3

Tag: "ultimate" at biology news

Tool developed to silence genes in specific tissues using RNAi

...NA interference (RNAi), believed by many to be the ultimate tool to both decode the function of individual genes in the human genome and to treat disease. Reporting in the journal Genes and Development, investigators have developed a simple way to use the RNAi approach to silence a selected gene in a specif...

St. Jude projects 90 percent cure rate for ALL

...eukemic. "MRD measurements help us to predict the ultimate response of each patient to treatment," Pui said. ...passing 90 percent is an important step toward our ultimate quest of curing all children with this disease." ...

Macrophage signaling may affect hormone resistance in prostate tumors

... the protein that binds there, called TAB2, is the ultimate target of the signaling pathway. When pro-inflammatory signals cause the chemical modification of TAB2, the activity of the receptors is changed. Drugs that are normally antagonists now activate target genes, many of which are associated with tumor ...

Faults in newly discovered breast stem cells may lead to tumours

...s of research in the area for years to come. The ultimate objective is to create a drug that will, in effect, switch off breast cancer cells. To do this, the exact makeup of genes expressed by normal and rogue stem cells will need to be determined. Then a drug will be designed to engage with and neutralize ...

Chemical signaling helps regulate sensory map formation in the brain

...ing and branching axons as they searched for their ultimate topographic positions within the brain. In the 1990s, scientists found the first of those signaling systems, a family of ephrin proteins that are present in graded fashion in the brain and are involved in axon guidance. The A-class ephrins are requi...

DNA end caps may lead to cancer treatments, UT Southwestern researchers report

... of the overhang is clearly very important for our ultimate ability to understand and manipulate these things for a variety of purposes," Dr. Wright said. The researchers believe that the rate of shortening is influenced by the length of the overhang ?more DNA is lost from ends that have longer overhangs. T...

Mice lacking key immune component still control chronic viral infections

...the most potent antiviral immune responses. "The ultimate relevance of these backup systems to human disease isn't known yet, but it's worth noting that we never would have even known to look for them if it weren't for our ability to study genetically altered mice," he says. ...

Genetic tug of war determines sexual differentiation

... said. "Based on our findings, we believe that the ultimate fate of the early gonads is controlled by mutually antagonistic signals between Fgf9 and Wnt4." Since the Sry gene occurs only in mammals, it is possible that this antagonistic signaling between Fgf9 and Wnt4 may be the mechanism that has remained c...

Stanford doctors advance in bid to turn mice stem cells into blood vessels

...ition of the Journal of Endovascular Therapy. The ultimate goal of the research is to bring together two of today's most promising areas of medical investigation: stem cell research and tissue engineering. Tissue engineering, the growth of organs and tissues outside the body for replacement, has achieved suc...

Wild bees and the flowers they pollinate are disappearing together

...the other. It's also not clear as of yet what the ultimate causes of the declines are, although land use change, agricultural chemicals and climate change may be important factors. The researchers hope to clarify these issues with follow-up studies. Dr Biesmeijer said: "Whatever the cause, the study provid...

Teasing out tissue from blood

It would be the ultimate in tissue therapy. Simply supply a bag of your blood and come back two weeks laterto find it turned into cells from other tissues, ranging from brain and liver cells to the insulin-producing beta islet cells of the pancreas. The idea is to revert a...

Discovery of agile molecular motors could aid in treating motor neuron diseases

... for example, could replace defective motors. "The ultimate goal is to find ways to treat motor neuron disease as well as other diseases that involve cellular motors and also construct nano-scale machines based on these biological motors," says Goldman. ...

Blood test predicts success of quitting smoking using the nicotine patch

...non-invasively using saliva or urine samples. "The ultimate aim here is to distinguish smokers who are likely to benefit from a standard dose of nicotine patch from those who may need a higher dose patch or an alternative therapy in order to succeed in quitting," said lead researcher for the study, Caryn Lerm...

Chimpanzee study reveals genome variation hotspots

..." "This study is an important first step, not the ultimate answer, but an exciting first step in studying the evolution of copy number variant regions and their downstream implications for disease and phenotypic variation," Perry says. In the study, researchers looked at the structural genomic variation in ...

Butterfly farming to help save rain forest

...d the surrounding North Rupununi District with the ultimate aim of enhancing the livelihoods of the 5000 individuals in the 16 rainforest communities in the Iwokrama forest through the sustainable development of a low-tech butterfly farming industry. The butterfly farming will be set up as a co-operative with...

Reversing 'hibernating' heart muscle focus of UB researchers

...d blood flow can be reversed more completely. The ultimate goal of manipulating these pathways will be to restore full contractile function." Areas of hibernating myocardium are common in patients with heart failure arising from coronary artery disease, Canty noted. "Determining how this impacts prognosis ...

Researchers find protein that silences genes

... para a Ciência e Tecnologia, Portugal. Pikaard's ultimate direction is to find out what makes the cell decide which set of ribosomal genes to silence. "We understand better how the silencing is happening, but we don't know how the choice is made," Pikaard said. "Another thing we want to know is how all ...

Results with newer bladeless LASIK equivalent to standard microkeratome LASIK

... did not differ between the LASIK surgeries. The ultimate goal of the Mayo Clinic study of microkeratome versus bladeless LASIK is to obtain long-term information about patients' vision and eye health five years following surgery. The results presented now represent the first six months of findings. ...

Epstein-Barr virus might kick-start multiple sclerosis

... could greatly contribute," he said. Whatever the ultimate cause of MS, Edwards finds the therapeutic implications of her work exciting. "For some reason, MS patients chronically accumulate these hyper-responsive T cells," she said. "And if these cells are indeed involved, either directly or indirectly, in c...

Cougar predation key to ecosystem health

...ortant to remember, the researchers said, that the ultimate driver behind all of these changes is humans ?in the case of Zion Canyon, simply by their presence. That canyon receives nearly three million human visitors a year, the adjacent North Creek a stray handful of hikers. Cougars in Zion Canyon were not i...

1 2 3 4 5