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Tag: "ubiquitination" at biology news

Bound for destruction: Ubiquitination protects against improper Notch signaling

...Hayashi et al. sought to study thepossibility that ubiquitination might play a part in rendering theunbound Notch receptor inert. Their attention was drawn to Nedd4 (amember of the ubiquitin ligase family of molecules that directly bindto proteins marked for degradation), as it had previously been shownthat Nedd4 p...

Insight into natural cholesterol control suggests novel cholesterol-lowering therapy

...as a selective, physiologic regulator of reductase ubiquitination and degradation," said DeBose-Boyd. That effect would, in turn, control the rate of cholesterol production. "In addition to the biological significance, the findings have important clinical implications for cholesterol control," he said. Cholestero...

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