DNA: Bacteria's survival ration
...ally competent germs. If researchers succeeded in turning off nutritional competence in such pathogens, as Finkel did in E. coli, the advance might lay the groundwork for a new class of genetic antibiotics. The study did not prove that all DNA decay is microbial. But Finkel discounted the significance of i...Adult stem cells are touchy-feely, need environmental clues
...tem cells seem ineffective in fixing the damage by turning into replacement cardiac muscle. "The cardiac ... not recognize the microenvironment as a guide for turning into heart muscle," Discher said; "however, our studies show that it might be possible to 'prime' st...FSU biologists uncover mechanisms that shape cells for better or worse
...y gene, we were able to restore normal polarity by turning Dystroglycan off artificially," he said. "While much remains unknown, our research confirms that EGFR regulation of Dystroglycan plays a key role in the polarization of the oocyte," Deng said. "That knowledge adds a pivotal link to our understandin...Study reveals how cells destroy faulty proteins in cystic fibrosis
...it in the molecular trash bin. The team found that turning off these components ?the cell's trash collectors -- extends the life of faulty CFTR proteins and thereby enables some of it to assume a functional shape. The trash collectors newly identified by the Cyr group are two different ubiquitin ligases,...Bedsores and bald hides: Novel roles revealed for a 'scaffolding' protein
...presence of K17 in these skin cells contributes to turning on the molecular pathways that lead to protein synthesis and cell growth, and this promotes timely healing of skin wounds," says Coulombe. "The capacity for wound healing decreases with age, and a better understanding of the fundamental mechanisms in...Dissecting the machinery of nicotine's reward
... "dopaminergic" neurons are known to be central to turning on the brain's reward mechanism. The stimulation of nAChRs by nicotine makes them more responsive to their natural triggering neurotransmitter, acetylcholine (ACh). Receptors such as nAChRs are complex proteins that nestle in the surface of cells an...Harmful Algal Blooms monitored from space in Chile
...d chlorophyll for photosynthesis -- the process of turning sunlight into chemical energy. The chlorophyll collectively tints the colour of the surrounding water, providing a means of detecting these tiny organisms from space with dedicated 'ocean colour' sensors onboard satellites. The CAP project utilises...Researcher gives hard thoughts on soft inheritance
...enetic modifications are known to be important for turning genes on and off during the course of an organism's life, but their importance in controlling inheritance has been debated. Many biologists are skeptical of any form of soft inheritance, where the genetic material is not constant, believing that it ...Loosen up, DNA: Leukemia gene changes genetic packaging
...make up our genes is largely known, scientists are turning more attention to broader mechanisms of how the body controls those genes, turning them on and off as needed. It's a crucial issue for diseases like cancer, where many genes are tur...Leptin found to control appetite and limb development in frogs
...these tadpoles, the leptin signal isn't capable of turning the feeding behavior off, but it does apparently tell their bodies that they've had enough to eat now, and they can begin sprouting limbs. "Leptin gets a lot of attention for its role in food intake, but it's clear that it does lots of other jobs,"...Drug dials down the energy within cells, UM researchers find
...y drugs block the function of enzymes, essentially turning them off," said Gary Glick, who is the Werner E. B...ibit the enzyme in the way most powerful drugs do, turning it off, you deplete the cell of ATP, and that's fatal," Glick said. "Our new work reveals the mechan...OHSU study says stem cell 'fusion' occurs in tumors
...anisms that may be at work in regenerating rapidly turning over damaged tissue, or may even be implicated in ...s in the cells. The gut protects itself by rapidly turning over its epithelial cells. Plus, when there is damage to the surface lining, it is critical that reg...Researchers find protein that silences genes
...otein plays in a major turn-off –in this case, the turning off of thousands of nearly identical genes in a hy...hylation or histone deacetylation, indicating that turning off one parental set of ribosomal genes was really the secret to nucleolar dominance. In other word...Light-sensitive photoswitches could restore sight to those with macular degeneration
...use the same color of light will turn one on while turning the other off. "Now we have photochemical tools for an on switch and an off switch for nerve cells," Kramer said. "This will allow us to simulate the natural activity of the healthy retina, which has on cells and off cells that respond to light in ...MRSA vaccine shows promise in mouse study
...thy people with no apparent risk factors have been turning up in emergency rooms with virulent S. aureus infections acquired from community rather than health care related sources. ...Iowa State researchers improving plastics made from corn and soy proteins
...ood as a reinforcing agent. The researchers are turning to high-powered ultrasonics ?high-frequency sound waves too high for human hearing ?to separate and disperse the platelets. It's a technology Grewell knows a lot about: he worked 12 years in research and development for the Branson Ultrasonics Corp. ...How does a zebrafish grow a new tail?
... can actually increase the rate of regeneration by turning on these genes," Moon said. The researchers also...on." Moon added that, because the same genes for turning on and turning off growth and development are found in humans, and drugs exist that can regulate thi...A simple feedback resistor switch keeps latent HIV from awakening
...on entering a cell, a virus often becomes dormant, turning off its genes and laying low until awakened by som e trigger from its environment. When that trigger is pulled, the virus quickly ramps up production of proteins through built-in positive-feedback loops that turn up gene transcription. (In positive f...New target for cancer therapy identified
... proteins Smad3 and c-Myc that are involved in turning off telomerase production. Their findings are published in the current issue of the Journal of Biological Chemistry. "It's significant to find inhibitors of telomerase and we have found, for the first time, the pathway that inhibits telomerase in hu...Gene therapy research switches off joint inflammation; switches on genetic process of joint repair
...t control joint destruction and inflammation while turning ‘on?the process of inserting glucosamine into new cartilage. Without this activated repair process glucosamine cannot be effective.1 So this solves a riddle that has plagued researchers for decades and corrects a problem that is exacerbated with a...