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Tag: "turned" at biology news

Duke Experiments Boost Radiation's Cancer-Killing Effects

...d a mutated form of HIF-1 into the cancer cell and turned it on and off by exposing it to the antibiotic tetracycline. With this reversible switch, the team could observe the effects while HIF-1 was active and when it was blocked. Drugs to block HIF-1 have been used in previous studies conducted at Duke an...

IBM Transforms the Art of Scientific Expeditions

...d a mutated form of HIF-1 into the cancer cell and turned it on and off by exposing it to the antibiotic tetracycline. With this reversible switch, the team could observe the effects while HIF-1 was active and when it was blocked. Drugs to block HIF-1 have been used in previous studies conducted at Duke an...

Sleeping beauty plays a significant role in identifying cancer genes

...linked to cancer by seeing whether Sleeping Beauty turned them on or off -- in effect, uncovering the fingerprint of each tumor's cancer genes. David Largaespada, Ph.D., associate professor and leader of the Genetic Mechanisms of Cancer Program, led the University of Minnesota Cancer Center research team. ...

One bacteria stops another on contact

...urinary tract infections, contains genes that when turned on block the growth of other E. coli bacteria that they touch. The finding was a complete surprise to the scientists, said Low. The discovery may eventually lead to new antimicrobial agents to halt bacterial growth which would be an entirely new sy...

Modification of program enables prediction of gene transcription

...derstand more about gene regulation ?how genes get turned on and off, the ignition system of our DNA, if you will. To make the proteins that are the basic micro-machines of life, a region of the genome is copied, or "transcribed," to form a molecule called messenger RNA (mRNA). Some segments of the mRNA ar...

'Underground' tunnels discovered as means for communication between immune system cells

...y those cells that discharged. A literature search turned up a handful of papers describing tunneling nanotubules, and further imaging using the highest magnification possible disclosed their presence in both the dendritic cells and macrophages. In their most definitive experiment, the researchers placed d...

Flies on speed offer insight into the roles of dopamine in sleep and arousal

...lly engineered flies whose dopamine cells could be turned off experimentally, or flies that have received dopamine inhibitors, show converse behavioral effects to those seen in normal flies that have ingested methamphetamine. The results suggest that the right balance of dopamine is necessary for proper bra...

World-first technology enables study of ancient bacteria

...hydrates and bacteria under high pressure. He has turned to experts in the University's Manufacturing Engineering Centre to help create a system that would enable his team to grow, isolate and study these ancient bacteria in the laboratory. "DNA analysis of deep sediments has shown diverse bacterial popul...

Researchers discover how malaria parasite disperses from red blood cells

... "The cell membrane was light sensitive. When we turned the light down, we didn't see the swelling." Rather, he said, upon release of the merozoites, the cell membrane appeared to contract in upon itself. Another theory held that the merozoite-containing vacuoles would fuse with the cell membrane, and t...

Locusts' built-in 'surface analysis' ability directs them to fly overland

...direction over Sinai up to the Gulf of Eilat, then turned northward without crossing the water. Only when the swarm reached the northern tip of the gulf did some of them turn again east in the direction of Aqaba and other areas of Jordan, as well as straight north over southern Israel. This observation led...

Virus uses tiny RNA to evade the immune system

...veral dozen predicted microRNAs, the top candidate turned out to be abundantly expressed in human cells infected with SV40. Sullivan soon found the target of the plentiful SV40 microRNA. It effectively targeted the messenger RNA for a protein known as T antigen, leading to its cleavage. "SV40 may be the wo...

Learning how SARS spikes its quarry

...ting humans. "Both of these critical amino acids turned out to be right in the middle of the interface between the spike protein and the receptor," said Harrison. Thus, the structure reveals details about how even small mutations in the spike protein gene that alter the identity of amino acids at those si...

Stolen gene allows insect virus to enter cells

.... "The first thing was to ask whether the gene was turned on or not, to validate whether it's a bona fide ge...r words, it might have been a host's own gene that turned baculoviruses into the lean, mean killing machines they are today. ...

Newly recognized gene mutation may reduce seeds, resurrect plants

..., a mutant of RST1, had short, rounded leaves that turned purple during development, and then before flowering, the plant quickly browned and looked dead. It also had a large proportion of small, wrinkled, non-viable seeds with aborted embryos. These contained only 34 percent of the normal amount of lipids....

Color perception is not in the eye of the beholder: It's in the brain

...g of starlight caused by the atmosphere. Williams turned the technique from the heavens back toward the eye to compensate for common aberrations. The technique allows researchers to study the living retina in ways that were never before possible. The pigment that allows each cone in the human eye to react ...

Method slashes quantum dot costs by 80 percent

...ssues of quantum dot manufacture, but the solvents turned out to be so expensive that we just couldn't afford to run more than a few large-reactor experiments," said the study's lead author, Michael Wong, assistant professor of chemical and biomolecular engineering and of chemistry. "That was a great realit...

The right drug at the right time

...ssues of quantum dot manufacture, but the solvents turned out to be so expensive that we just couldn't afford to run more than a few large-reactor experiments," said the study's lead author, Michael Wong, assistant professor of chemical and biomolecular engineering and of chemistry. "That was a great realit...

New antibody shows promise as cure for anthrax

... a New Jersey-based biopharmaceutical company, who turned it into a full immunoglobulin G (IgG). In trials, Elusys has found that the IgG protects test animals from anthrax when administered both before and after exposure to the disease. Since those findings, Dr. Robert Mabry of the Iverson and Georgiou ...

Researchers find Amchitka seafood safe for now

... itself by University of Alberta's Martyn Unsworth turned up additional new information. By using advanced remote sensing to explore the rock substructure, it has found clear evidence that the likely path to the sea of any nuclear material that leaves the cavities created by the nuclear test shots will trav...

MicroRNAs have shaped the evolution of the majority of mammalian genes

...ironment. To answer this question, the researchers turned to gene expression patterns of different types of mouse cells. Kyle Kai-How Farh, a graduate student in Bartel's lab, found that mRNAs with nonconserved sites were generally absent in cells with corresponding microRNAs--more absent than statistical ...

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