tumors 2 5

Tag: "tumors" at biology news

A new target for painkillers

...disc disease, alcoholism, failed low-back surgery, tumors compressing nerves, spinal tumors, repetitive motion disorders, multiple sclerosis, infection, stroke, traumatic brain injury, shingles, nerve toxins and electrical or other damage to peripheral nerves. Sometimes, doctors are unable to find a cause. ...

Antibody extends life of mice with breast cancer

...ntly the survival of mice with human breast-cancer tumors and to inhibit the cancer's spread to the lungs in...f the journal Neoplasia. Mice with breast-cancer tumors that received the antibody had a median survival time of 72 days, compared to 57 days for the animal...

Plant-derived molecules, genetic manipulation point to future chemoprevention methods

...rterpenoids and the rexinoid LG100268 prevent lung tumors induced by vinyl carbamate in strain A/J mice N...currently undergoing trails for leukemia and solid tumors (sponsored by Reata Pharmaceuticals), significantly reduced the number and sizes of tumors in mice. ...

Mutant mouse provides insights into breast cancer

... biology Bik Tye, while the pathology of the mouse tumors was performed by Ana Alcaraz, a veterinarian in Cornell's Section of Anatomic Pathology in the Department of Biomedical Sciences. ...

'Trojan Horse' agent halts bone metastasis in mice

...agent completely prevented the development of bone tumors in 50 percent of the mice tested in a preclinical ...evidence that it could treat, or thwart, growth of tumors in bone, a common destination for a number of cancers when they start to spread. Researchers at The...

U-M researchers use nanoparticles to target brain cancer

...these nanoparticles can be used to image and track tumors as well as destroy them, according to researchers ...ains in part why some current treatments for brain tumors are generally not effective. Targeting the tumor vasculature with nanoparticles containing a payload...

Researchers discover that sheep need retroviruses for reproduction

...us Jaagsiekte Sheep Retrovirus or JSRV causes lung tumors in sheep and led to the death of Dolly, the world's first mammal cloned from an adult cell. The idea that endogenous retroviruses are important for reproduction in mammals has been around for about 30 years, Spencer said. Studies in cultured cells ha...

Report calls for improved monoclonal antibodies against solid tumors

...nly three are used on solid tumors. However, solid tumors account for 85 percent of all cancers. Accordi...eveloping monoclonal antibody treatments for solid tumors has been their ability to penetrate the tumor. To be effective, the treatment “must gain access to a...

High-throughput oncogene mutation detection in human cancers by mass spectrometry-based genotyping

...hat drives development of gastrointestinal stromal tumors (GISTs), and certain EGFR mutations that are responsible for one form of lung cancer. These cancers can be treated with the targeted therapies Gleevec and Tarceva, respectively, which shut down the affected oncogenes. The test involves taking a samp...

Older men treated for early prostate cancer live longer than those who are not

...rostate cancer patients, aged 65 to 80, with small tumors that were at a low or intermediate risk of spreading," said senior author Katrina Armstrong, MD, MSCE, who worked on the study with colleagues from Penn's Abramson Cancer Center, Center for Clinical Epidemiology and Biostatistics, Leonard Davis Insti...

Spelling out cancer on the nanoscale

... to read trace oncoprotein levels from early-stage tumors would speak volumes to physicians and cancer resea...e new nano-fluidic system was also tested on human tumors by measuring the levels of MYC, BCL2, ERK, and AKT proteins in the lymph nodes obtained from patient...

Abnormal overexpression of p53 is a predictive molecular biomarker

...als, that 73 percent of patients with p53-positive tumors responded to the therapy, compared to a 14 percent response in patients with tumors that were p53-negative. Median survival also increased to 11 months for p53-positive patients, compa...

Researchers image molecular motor structural changes

... on all dividing cells, not just those involved in tumors or cancers, and so causes unwanted side effects, such as hair loss. "With this new information about kinesins and how they interact with microtubules, the hope is that we will be able to develop drugs that can target specific kinesins," Endow said. ...

Mayo Clinic: Gene expression profiling not quite perfected in predicting lung cancer prognosis

...ing has been successfully used to classify various tumors and assess tumor stage, metastasis and patient survival rates, the evidence suggests that gene-based prediction for lung cancer is not yet entirely dependable. However, some results have been promising: gene profiling has reliably predicted patient ...

Newly discovered behavior in cancer cells signals dangerous metastasis

...ate a new tumor site. "Our findings validate that tumors are highly complex in their behavior and don't nec...steps that occur during the natural progression of tumors could lead to therapies for blocking metastasis, he said. ...

World's smallest cancer detection device

...stitute to study tumor "microenvironments" --where tumors interact with surrounding tissues, cells and chemicals in ways that all too often encourage cancer cells to invade other areas of the body in the process known as metastasis. With the new NCI grant, Dr. John Condeelis, co-chair of anatomy and struc...

Two-faced protein can stop metastasis or promote it, researchers say

...aking them apart and promoting their movement when tumors begin to spread to other parts of the body, researchers at Mayo Clinic have found. The study, published in the Sept. 18 online issue of the Journal of Cell Biology, helps illuminate the very first steps involved in metastasis, the spread of cancer t...

Innovative movies show real-time immune-cell activity within tumors

...est tube, and then reintroduced into mice carrying tumors that either did or did not express the antigen. This procedure, referred to as adoptive transfer, is an immunotherapy strategy against cancer being tested in a number of human clinical trials. In some of those trials, a patient's own T cells are remo...

More kidney cancer is detected and treated early, yet death rate rises

...ey cancer (also known as renal cell carcinoma) for tumors of all sizes. But the greatest increases in kidney cancer incidence were among tumors 4 centimeters or smaller. Tumors of this size, often found in patients without any clinical signs or...

Three-dimensional, miniature endoscope opens new diagnostic possibilities

...rchers used the system to image metastatic ovarian tumors on the abdominal wall of a mouse. The SEE probe was passed into the abdominal cavity through a fine-gauge needle. The resulting three-dimensional image showed several raised areas of tumor nodules, the presence of which was confirmed by histologic ...

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