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Tag: "tumors" at biology news

HIV protein enlisted to help kill cancer cells

...ling effect of radiation. When mice with malignant tumors were treated with TAT-Bim, their tumors shrank, and they survived longer than mice that didn't get the treatment. After 40 days, 80 percent ...

Inflammation may play role in metastasis of prostate cancer

...at inflammation associated with the progression of tumors actually plays a key role in the metastasis of pro...d one in 33 will die of metastatic disease. Early tumors confined to the prostate can be treated, but no effective treatments are available for metastatic di...

Gene expression test reveals ER and HER-2 status of breast tumors

...ogy, and team leader with Symmans. ER-positive tumors are treated with estrogen-suppressing drugs such a...raditional immunohistochemical lab analysis of the tumors by 8 percent for ER and 11 percent for HER-2. The researchers note this degree of discrepancy is usu...

Molecular signature may identify cisplatin-sensitive breast tumors

...ibes a specific molecular pathway that makes these tumors sensitive to a therapy infrequently used for breas... a growth-promoting protein called HER2, and those tumors are candidates for treatment with the monoclonal antibody Herceptin. The third major subtype is the...

Intravenous nanoparticle gene therapy shows activity in stage IV lung cancer

...ing gene has been successfully delivered into the tumors of stage 4 lung cancer patients via an intravenous...nt and post-treatment biopsies of three patients' tumors show that expression of FUS1 was absent from pretreatment samples while a high level of FUS1 was ex...

Napoleon's mysterious death unmasked, UT Southwestern researcher says

... were present around the stomach and there were no tumors in other organs. Only 20 percent of patients with Stage IIIA gastric cancer survive five years if treated with modern surgery and chemotherapy. But what might have caused Napoleon's cancer? Risk factors for gastric cancer include male gender, g...

Small molecule dervived from Rb2/p130 could act as cancer therapeutic

...umor cells. "Tumor growth was inhibited and the tumors began to reduce in size until they disappeared," Giordano said. Giordano said because of the intrinsic nature of the compound, it can be easily reproduced as a biological drug in large quantities and does not require potentially dangerous means of...

Scientists uncover new target in cancer mutation puzzle

...posite approach. They are looking for ways to stop tumors by interfering with features of cancer cells depen...s a target of cooperating cancer gene mutations in tumors with p53 mutations, we will look for other molecules with similar features," Land said. "Our hope is...

Knocking out survival protein could aid leukemia treatment

...atients with advanced cancer or from patients with tumors that resisted conventional treatment. When the researchers treated cells with both siRNA and the drug rituximab, the combination killed significantly more leukemia cells than the drug alone. Overall, says Byrd, "Our data indicate that specifi...

Stanford scientists make major breakthrough in regenerative medicine

...ten the result is invalidism or disease. Even some tumors try to revert to normal, but are unsuccessful. If the genetic sequence described in the sea squirt applies to humans, this study represents a major step for regenerative medicine. The sea squirt is more closely related to humans than many would ...

MicroRNA helps prevent tumors

...ally regulated by microRNAs, can help give rise to tumors if a mutation in the gene disrupts the microRNA's ability to regulate it. In addition, the results show that the interaction of one microRNA with one of its target genes can produce a certain trait in mammals. This is important because scientists are...

Adding radiation decreases breast cancer recurrence

...ence and prevents development of additional breast tumors in older women with early stage breast disease, ac... the occurrence of recurrent and additional breast tumors for this patient population. This analysis was part of a larger study led by Rebecca Silliman, M.D.,...

Linheng Li Lab documents the development of cancer stem cells

...ed cancer stem cells and shown that they may cause tumors when transplanted into a secondary host. Until now, however, little was known about the process by which mutations in a stem cell result in primary tumor initiation. The Li Lab team studied the intestinal system in mice in which one of the human...

Reactivated gene shrinks tumors

...re-activating one of those genes in mice can cause tumors to shrink or disappear. The study offers evidenc... can find drugs that restore p53 function in human tumors in which this pathway is blocked, they may be effective cancer treatments," said David Kirsch of MIT...

Nanoparticles can track cells deep within living organisms

...cells like these could prove useful for monitoring tumors and diagnosing and treating cardiovascular problem... and incorporate into blood vessels forming around tumors in mice. The researchers believe the cells could soon be used in clinical settings. "Kathy and c...

Turning a cellular sentinel into a cancer killer

...he p53 gene in mice, causing blood, bone and liver tumors to self destruct. The p53 protein is called the "g...ctivated p53 in the mice they found that the liver tumors completely disappeared. "This was quite surprising," said Lowe. "We were working with a very advance...

Chemicals in brown algae may protect against skin cancer

...h cases, the substances reduced the number of skin tumors by up to 60 percent and their size by up to 43 per...le. The researchers then counted the number of tumors in the treatment and control groups and calculated their size. Animals exposed only to UVB devel...

Creating new life forms that may help eradicate cancer affecting women

...apable of treating breast cancer in patients whose tumors express the HER-X/Neu protein." Advaxis has already created several strains for potential use in future vaccines to treat other cancers. The company is also currently testing its cervical cancer vaccine, Lovaxin C, in phase I/II trials. ...

Nanoparticles for delivery of prostate cancer treatment

...blood vessels of solid tumors, thus destroying the tumors while leaving normal tissue unharmed. The tech...cells lining the inner surface of blood vessels in tumors but not in normal tissues. The Icon binds to TF more strongly and specifically than a natural antibo...

Cryoablation -- A new treatment option for some kidney tumor patients

...ayo Clinic researchers report that freezing kidney tumors through percutaneous cryoablation shows promise fo...e of Radiology. The standard treatment for kidney tumors is surgery, providing a high likelihood of a long-term cure. For some patients, surgery is not an o...

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