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Tag: "tumors" at biology news

UC Davis researchers use heated nanoprobes to destroy breast cancer cells in mice

...ers have used hot nanoprobes to slow the growth of tumors -- without damage to surrounding healthy tissue. The researchers describe their work in the March issue of the Journal of Nuclear Medicine. "We have demonstrated that the system is feasible in laboratory mice. The next step will be clinical testing ...

Navigable nanotransport

... covered with folic acid molecules. What for? Many tumors have a significantly increased number of folic acid receptors on the surfaces of their cells. The folic acid on the capsules docks into these sites and is brought into the interior of the cell. Here, the contents of the capsule, such as an antitumor ...

Penn researchers show how nanocylinders deliver medicine better than nanospheres

...the size of blood cells. The paclitaxel shrunk the tumors and, because the cylinders remained in circulation... dose, killing more cancer cells and shrinking the tumors to a much greater extent. Spherical nanoparticles typically only stay in circulation for a few hours...

Researchers identify ovarian cancer biomarkers

...ique to isolate blood vessel cells from 21 ovarian tumors and four normal ovarian tissue samples. From there...of the markers present in large amounts in ovarian tumors were not expressed by normal ovaries or other healthy organs. The researchers also found these marke...

RNA splicing factor implicated in ovarian tumor cell growth

...n a previous study, we observed that human ovarian tumors overexpressed polypyrimidine tract-binding protein, or PTB, and another splicing factor compared to normal matching ovarian tissues," said William Beck, professor and head of biopharmaceutical sciences. In the new study, Beck and research assistan...

Hybrid molecule causes cancer cells to self-destruct

... Efforts to use butyrate as a general drug for tumors elsewhere in the body, however, have been hindered by the high doses of the compound needed to effectively eradicate cancer. To get around this problem, scientists have tried to make butyrate more potent by modifying it or joining it to other compoun...

A genetic 'gang of 4' drives spread of breast cancer

...could reduce the growth and spread of human breast tumors in mice by simultaneously targeting two of the pro...reased both their ability to grow large aggressive tumors in the mouse mammary gland and also the ability to release cells from these tumors into the circulat...

Genetic pathways to curable and incurable forms of pancreatic cancer identified

...utations arise." About 5 percent of all primary tumors of the pancreas, out of 40,000 annual new cases in the United States, arise from cystic tumors. The findings reported in the journal by Hingorani and colleagues represent an accidental discovery. The researchers started out studying the common gen...

New protein inhibitor impedes growth of cancerous cells

...hey show that the inhibitor can halt the growth of tumors in mice and cancer-derived cells growing in culture. The findings are reported in companion papers reported by two collaborating groups—one (Lenart et al.) led by Jan-Michael Peters of the Research Institute of Molecular Pathology in Vienna, and the ...

Molecular differences between early and advanced melanomas could provide new drug targets

...cer Society. But when melanomas grow downward, the tumors become highly resistant to chemotherapy and radiat...f microscopic blood vessels that nourish cancerous tumors and lead to unregulated cell growth. When melanoma cells overexpressing Akt were introduced into im...

Mechanisms involved with tumor relapse identified

...une system in response to invasion by pathogens or tumors in order to protect the host against infection or ...duction of interferon gamma by lymphocytes against tumors is considered a sign of good prognosis; however, recent study findings indicate that this may not be...

Vasectomy may put men at risk for type of dementia

... as a parallel," Weintraub said. Certain malignant tumors produce antibodies that reach the brain and cause an illness similar to encephalitis, she noted. The next step in Weintraub's research will be to launch a national study to see if her results will be confirmed in a larger population. "I don't ...

MicroRNAs as tumor suppressors

...s an important feature of many medically important tumors like uterine fibroids,?explains Dr. Dutta. “It is very exciting to realize that microRNAs have an important role in suppressing the overexpression of HMGA2, and so may have a role in the causation and perhaps the cure of a disease that is responsible...

New cell type identified in cancer development

...tment. Current cancer stem cell theory holds that tumors are comprised of a variety of cell types. Among t...d lymphoma, and that several cell lines from those tumors carried a unique and provocative phenotype, or surface protein signature: They carried neither the S...

Researchers urge monitoring of bone health during chemotherapy

...fects of chemotherapy induced bone loss and helped tumors grow in bone. So the researchers at Washington University School of Medicine in St. Louis are recommending increased awareness of bone health during cancer treatments. The medication studied is a growth factor commonly used to help cancer patients ...

Finnish scientists discovered a new approach to treat virus-induced lymphomas

...a treatment resulted in a marked regression of all tumors in the treated animals in two weeks. These results demonstrate that p53 reactivation via Nutlin-3a is an efficient treatment for KSHV-lymphomas in mice and suggest a novel therapeutic strategy for treatment of these fatal virus-induced malignancies a...

Genes and biomarkers that allow doctors to choose the right therapy for the right patient

...biomarkers associated with cetuximab, including in tumors without the KRAS mutation that do not respond to t...ingly." The researchers screened lung and brain tumors to determine which peptides ?or protein fragments ?were active in the tissue environment surrounding...

No carrier necessary: This drug delivers itself

... those that are hydrophobic or water-repellant, to tumors or other disease sites has long challenged scienti...und that the nanocrystals of HPPH were taken up by tumors in vivo, with efficacy comparable to conventional, surfactant-based delivery systems. A patent has...

Selective marker found to indicate aggressive form of breast cancer

...it has a chance to come back." Basal epithelial tumors lack important molecular targets such as the estro...zo. In a retrospective study of breast cancer tumors lacking estrogen receptors, progesterone receptors and Her2, DiRenzo and his colleagues found extrem...

Dual gene therapy suppresses lung cancer in preclinical test

...umber and size of human non-small cell lung cancer tumors in mice, researchers at The University of Texas M.... when administered together, cutting the number of tumors per mouse by 75 percent and the weight of tumors by 80 percent. "In cancer treatment we have comb...

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