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Tag: "tumor" at biology news

Source of crucial immune cell in the skin discovered

...s are particularly important to the development of tumor immunotherapy," said Miriam Merad, MD, PhD, Assist...to engineer immune responses in vaccine design and tumor immunotherapy and to a better understanding of the immune response against skin pathogens." "Now th...

Cellular scale drug delivery from the inside out

...e the nanospheres at a particular point, such as a tumor site, and then use the magnetic field to remove the caps and release the drug," Lin said. "The advantage of using a magnetic trigger as opposed to a ultraviolet light trigger is that there's no limit to the depth of tissue we are able to probe ?think...

Swiss researchers develop all-in-one remote control gene expression tool

... this tool could be used to study gene function in tumor cells and for generating in vivo tumor models for drug screening and delivery. In another application, dying cells (such as neurons) can ...

'Virus chip' detects new virus in prostate tumors

...had been surgically removed. Among the 20 prostate tumor samples from men with mutations in both copies of ...nique to prostate tumors because this is the first tumor type they have studied using virus chip technology. As with most scientific discoveries, the identif...

Infection 'alarm' yields clues to immune system behavior

...ich focused on how a large protein molecule called tumor necrosis factor, or TNF, triggers an immune response, were reported in the February issue of the Journal of Biological Chemistry. "We were surprised by how sensitive cells were to small amounts and brief exposures to TNF," said Andre Levchenko, a Jo...

Canine cancer vaccine program shows early promise

...ear. But about 40 percent of dogs with a melanoma tumor present responded to a vaccine created from actual melanoma tumor cells. In about 12.5 percent of the treated dogs, the tumor completely disappeared. While the curre...

BiovaxID?yields 89 percent survival in patients with aggressive non-Hodgkins

...imulates the immune system to seek out and destroy tumor cells. The data were published in a recent edition of Nature Medicine (Nat Med.2005; 11(9):986-91). In this single-arm, open-label Phase 2 clinical study, patients with untreated mantle cell non-Hodgkin's lymphoma (NHL) were administered six cycle...

Evolutionary biology research techniques predict cancer

...ancer, the more genetically diverse a precancerous tumor is, the more likely that tumor is to progress to full-blown cancer. If so, genetic diversity might act as a biomarker for cancer ri...

Researchers create pigs that produce heart-healthy omega-3 fatty acids

...ancer, the more genetically diverse a precancerous tumor is, the more likely that tumor is to progress to full-blown cancer. If so, genetic diversity might act as a biomarker for cancer ri...

Terahertz imaging may reduce breast cancer surgeries

A promising new technique to ensure complete tumor removal at breast cancer excision is introduced in...reliably distinguish between normal breast tissue, tumor and even early-stage 'in situ' cancers in excised tissue samples," said Vincent P. Wallace, Ph.D., l...

Light activated anticancer drug targeted to DNA using cisplatin like sub-units

...r complex (supramolecule) that exploits cisplatins tumor targeting to deliver a light activated drug. The ...atin like units, directing the light activation to tumor cells and the sub-cellular target, DNA. "In the past, our light activated systems had to find the ...

Predicting success

...al "wants" to spread out evenly, fluids inside the tumor may be exerting pressure to prevent this. When the...e growth and the pressure of the fluids inside the tumor tissue. The Weizmann Institute team's research, as well as that of other research groups, shows that...

Nanotechnology may find disease before it starts

...lls of the leaky blood vessels, or capillaries, of tumor tissue and actually infiltrate the tumor. "Until now, nobody knew what these particles would do in the blood," Rosol said. "But they made it into the liver. And despite their miniscule size, nanoparticles are still big enough to carry a payload of ...

Mayo Clinic collaboration discovers protein amplifies DNA injury signals

...table. Genomic instability is the driving force in tumor formation, which is why cancer researchers around the world are focusing on understanding the DNA damage response pathway. Knowing how the cell communicates DNA injury to alert the repair system is an important first step to designing new therapies f...

New hybrid virus provides targeted molecular imaging of cancer

...specific "zip codes" on their blood vessels, as do tumor blood vessels. Knowing this, Pasqualini and Arap designed, constructed, evaluated, and validated the targeted AAVP system over the past several years. Amin Hajitou, Ph.D., a post-doctoral fellow in the Arap/Pasqualini laboratory and first author of t...

New cellular flaw found in some virulent breast cancers

...ulent proliferation of cancer cells and creating a tumor with a very poor prognosis. "The development of cancer drugs like Gleevec and Iressa have shown that it is possible to block the action of kinases," said Sicinski, "so we hope that these findings will stimulate interest in developing drugs to block ...

New compound protects against liver cancer

...s. Other oleanolic derivatives are known to reduce tumor growth in animals and humans. Researchers believe CDDO-Im works by activating Nrf2, a master switch known to direct certain enzymes to stimulate the cell's defense mechanisms and remove harmful chemicals from cells. "Activation of the Nrf2 pathway w...

Botox could help target resistant tumors for treatment

...focuses on briefly opening blood vessels that feed tumor cells in order to better deliver therapeutic agent...e: reduction of blood vessel growth, which starves tumor cells of nutrients. "Tumor vasculature is targeted by several advanced anti-cancer approaches that...

Curry and cauliflower could halt prostate cancer

...nation of curcumin and PEITC significantly reduced tumor growth. ...

Tool developed to silence genes in specific tissues using RNAi

...ed how well their tool worked by silencing the WT1 tumor suppressor gene in the testes of mice. They found this gene is important in the production of healthy sperm by encoding a regulatory protein called a transcription factor that controls the formation of adherens junctions, or the cell-to-cell contacts...

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