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Tag: "tumor" at biology news

Discovery suggests why stem cells run through stop signs

...in called Dacapo, a fruit fly homologue of a human tumor suppressor) kept the stem cells from proliferating. "Determining which of the 80 microRNAs is responsible for deactivating the stop signal is the next step of our research," said Ruohola-Baker. "The list of chores that microRNAs do within cells kee...

Sleeping beauty plays a significant role in identifying cancer genes

...sons jumped into cancer-causing genes and caused a tumor to form. By isolating and studying the genes from tumors that contained Sleeping Beauty, researchers were able to efficiently find genes linked to cancer by seeing whether Sleeping Beauty turned them on or off -- in effect, uncovering the fingerprint...

AACR Favors 'full spectrum of stem cell research biology'

...ignant tumors, raising the prospect of eliminating tumor recurrence following initial treatment and developing cancer therapies that are truly curative. # Embryonic stem cells' ability spontaneously to form tumors should not hinder the progress of stem cell research, since these cells will be used only as...

Change in gene may be underlying molecular defect in some colorectal cancers

...l-appearing colon mucosa up to 10 cm away from the tumor had detectable MGMT methylation. In addition, the ...ition, "given the high lifetime risk of colorectal tumor development in the U.S. population, it is reasonable to propose testing to determine whether healthy...

'Underground' tunnels discovered as means for communication between immune system cells

... do not exist between commonly used fibroblast and tumor cell lines. Interestingly, if not for a minor mishap while carrying out an experiment, the authors might not have discovered the existence of these physical structures and conducted the studies that revealed their role in intercellular communication...

Two designer drugs hit same lung cancer target, but only one is effective

... predictions were confirmed: all patients had some tumor shrinkage when they received Iressa, but none of the cancers responded to Erbitux. Janne says that the experiment told the scientists something new about the biology of the EGFR mutation in NSCLC. "The lesson is, to inhibit the mutant receptor, you ...

Columbia scientists develop cancer terminator viruses

...d kills breast cancer cells in mice. Human breast tumor xenografts were established on both sides of immune-deficient mice. Results found that treating the tumors on just one side of the animal with very few injections of this modified virus not only cured the injected tumors, but also resulted in the de...

Researchers discover how tumor suppressor gene works

...owing rapidly, a condition that sometimes leads to tumor formation. Working with mouse epidermis and cultured human melanoma and nonmelanoma cancer cells, the team found that p16 inactivates key enzymes -- called JNK 1 and JNK 2 -- in the process. The enzymes are normally activated by exposure to ultraviol...

Carnegie Mellon cyLab researchers work to develop new red tide monitoring

...for this software might range from studying cancer tumor growth to tracking serial killers. "The other very important part of this research is to adapt our findings to homeland security where we may use this method to track the bioterrorism activities pertaining to the nation's waterways." Cai said his NA...

Suppressing growth hormone in early adulthood may prevent cancer

...ical Center. IGF-1 in the blood also may act as a tumor promoter during the early development of cancer, he said. Although additional research is needed, he said, drugs in the somatostatin class are currently available to suppress growth hormone and IGF-1 in people, so somatostatin analogs could be given...

Vaccine targets tumors where they live

...gues from Columbia University manipulate the local tumor environment as a method for improving systemic ant...rapy. This approach may be useful for altering the tumor environment in order to induce anti-tumor immunity and provides a foundation upon which other vaccin...

Researchers discover new tumor defense system

...ty of the cytotoxic T lymphocytes to recognize the tumor and a physical barrier separating the lymphocytes ...hibit the cytotoxic T lymphocytes' ability to kill tumor cells. "We found two things," explains Dr. Kleinfeld. "First, the most common type of free fatty ac...

Breast tumors in mice eradicated using cancer vaccine

... enlist killer T cells to seek out and destroy the tumor cells that display the HER-2/Neu molecule. "We found that we can stop the tumor from growing out to 100 days, at which time we stopped measuring since this is a long time for exper...

Drugs from the deep blue

...oratory, can inhibit the growth of a wide range of tumor cell types even at very low concentrations. It appears to block cancer cells from dividing at a different, earlier step than that targeted by other clinically important anticancer drugs. "It uses a different mechanism to any known drug, it's unlike ...

Optimizing cell therapy against tumors is a balancing ACT

... and early effector T cells are more effective for tumor treatment than more differentiated T cells. In an accompanying commentary, Daniel Speiser and Pedro Romero write, "optimal therapeutic efficacy may depend on different T cell selection and preparation strategies" and these findings indicate that a p...

Eleven gene 'signature' reliably predicts cancer prognosis

...lls exists among the mix of other cells found in a tumor and that these tumor stem cells are responsible for tumor progression and metastasis. In a revolutionary study appearing ...

Neurotransmitters signal aggressive cancer, offer potential for early diagnosis

...d on the poor prognosis but not the good prognosis tumor groups." "Most people understand the revolution i...researchers believe that metastatic neuroendocrine tumor cells use GABA signaling processes to communicate with each other and with their environment. "Throu...

UW-Madison scientists zero in on drugs' sweet spots

...eriments that boosted the cell-killing potency and tumor specificity of the drug, derived from the foxglove plant and used to stimulate the heart. The drug is suspected to have anti-cancer properties, but its use to treat cancer has been little explored. The new work is important because it provides scien...

Firefly protein lets researchers monitor molecule linked to cancer

...ly protein, luciferase, to monitor IKK activity in tumor cells and inflamed liver cells in live mice. They ... in live mice by transplanting genetically altered tumor cells and by using a technique that inserted the fused IKB/luciferase protein into liver cells only....

UT Southwestern researchers discover master switch in cell death

...ngs also suggest a new drug target for controlling tumor formation. Dr. Xiaodong Wang, professor of bioche...lp cancer patients, Dr. Wang said. For instance, a tumor may contain cells with a deficit of Mule, making the tumor more likely to grow and perhaps be resist...

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