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Tag: "tumor" at biology news

New tumor-suppressor gene discovered

...lso has discovered how the gene works with another tumor suppressor to control tissue growth. The team's ge...tified defective mats genes in a human skin-cancer tumor and in a mouse breast-cancer tumor. "In these tumors, we found that the mouse counterpart and the hu...

Turning viruses into allies against cancer

...te, commandeer, replicate and destroy, but only in tumor cells and not surrounding healthy tissue. Several...lls, is being tested in patients with a variety of tumor types, including melanoma, breast, head and neck, and colorectal cancer. In early clinical studies,...

Novel gene-silencing nanoparticles shown to inhibit Ewing's sarcoma

... that transports gene silencing nanoparticles into tumor cells has been shown to inhibit Ewing's sarcoma in...s iron into cells is modified to also smuggle into tumor cells siRNA (short interfering RNA) encased in nano-sized sugar polymers. The siRNA was designed to ...

Chromosome Deletion Predicts Aggressive Neuroblastoma

... of all pediatric cancers, often occurs as a solid tumor in a child's abdomen or chest. Some cases of neuro...site apparently removes the protective effect of a tumor suppressor gene, and thereby allows the tumor to grow. Patients in the study with the chromosome del...

Researchers find promising cancer-fighting power of synthetic cell-signaling molecule

... not know why Enigmols affect such a wide range of tumor cell types," Merrill said. "But it may be due to the involvement of sphingolipids in multiple cell-signaling pathways. This means a compound may affect several different targets, rather than just one." In essence, Enigmols may act like a multi-drug ...

NYU and MSKCC research provides model for understanding chemically induced cancer initiation

...ange in shape in a carcinogen-damaged DNA site--in tumor suppressor genes altered by a known cancer-causing...epartment. The studied gene, p53, is an important tumor suppressor gene that plays critical roles in cellular functions such as cell-cycle control, differen...

Study reveals dramatic difference between breast cancers in US and Africa

... fellowship in Olopade's laboratory, to gather the tumor samples from three regions of Nigeria, and later f...o. "We now have the world's largest collection of tumor samples from Africa," said Olopade. "Francis did most of that over the course of one year. That shou...

NSAID drug protects against intestinal tumors in mice, despite poor diet and gene losses

... the p21 gene, which they found put a firm stop on tumor formation even though the mice were missing two key tumor suppressor genes (p27 and APC) and were fed a diet high in fat and low in calcium and vitamin D. "I...

Measuring Enzymes At End Of Cancer Pathway Predicts Outcome Of Tarceva, Taxol

...ed chemotherapy drug Taxol are effectively killing tumor cells. They say that with further refinement, the ... to accurately test the function of enzymes from a tumor sample, says Naoto Ueno, M.D., Ph.D., an associate professor in the Breast Cancer Translational Rese...

UCLA scientists store materials in cells natural vaults

...elivery, such as homing cancer drugs directly to a tumor cell without harming healthy tissue * Enzyme delivery to replace missing or defective enzymes, such as those that cause Tay Sachs disease * DNA delivery to correct genetic mutations * Timed release of drugs, enzymes and DNA * Extracti...

Bevacizumab Combined With Chemotherapy Improves Progression-Free Survival for Patients With Advanced Breast Cancer

...). VEGF is a protein that plays a critical role in tumor angiogenesis. “It is noteworthy that a previous company-sponsored trial in patients who received prior chemotherapy for advanced disease did not show a benefit with bevacizumab in combination with capecitabine, a different chemotherapy agent,?said J...

Disease progression model of pancreatic cancer developed by Penn researchers

...cancer: Kras, an oncogene, and p53, a well-studied tumor suppressor. The investigators linked physiological...colleagues studied cell lines derived from primary tumor and metastasized cells. From this, the researchers established the occurrence of genomic instability...

Unchecked DNA replication drives earliest steps toward cancer

...s for cancer as mutations in specific oncogenes or tumor suppressor genes. Full-blown tumors and metastatic... mutations in a certain few genes, such as the p53 tumor suppressor gene, are found in so many different cancers. Mutations in p53 are found in the majority ...

Structure-building cell signals also may influence learning and memory

...ti-proliferation signals and, as a result, trigger tumor progression," said Yamaguchi. "But this is a novel finding in biology, and we can only just begin to speculate on the broader implications of Ephrin and EphB's activity." Yamaguchi is a professor of developmental neurobiology at the Burnham Institut...

'Smart drug' targets deadly brain cancer

...an incurable form of recurrent brain cancer slowed tumor growth in more than one-third of the 65 adult pati... The NCCTG study addressed the most common kind of tumor arising from brain tissue of adults, glioblastoma mutiforme. Current treatment outcomes for this typ...

Characterizing Skin Cancer by Microarrays

... can be used to identify each stage of skin cancer tumor (melanoma) progression, according to a newly published report. Melanomas grow in two phases: radial and vertical. Vertical-phase tumors are more likely to metastasize (spread cancer to other parts of the body) than radial melanomas. Christopher Haq...

Gov't Creates Gene Database of Normal Human Tissues

...hich to compare gene expression data obtained from tumor or other disease specimens, and should be a valuab...zed 100 samples of the most common pediatric solid tumor cancer, neuroblastoma (NB), which accounts for 7 percent to 10 percent of all childhood cancers. Eve...

Whole-body MRI Takes Less Than 20 Min To Scan A Patient's Entire Body For Cancer Spread To Bone

...two methods is the future in primary and recurrent tumor detection and staging,?said Nadir Ghanem, MD, lead researcher on the German study. Dr. Ghanem will present the full results of the study on May 17 during the American Roentgen Ray Society Annual Meeting in New Orleans, LA. ...

Penn Researchers Use Robotic Surgery

...t mouth and throat cancers will allow for complete tumor removal while helping to preserve voice and swallowing function. "The daVinci Robot has been FDA-approved and successfully integrated into cardiac and urologic surgery. Patients are reaping the benefits with decreased bleeding, less pain, and are abl...

Two new retroviruses—transmitted from animals—identified

...t mouth and throat cancers will allow for complete tumor removal while helping to preserve voice and swallowing function. "The daVinci Robot has been FDA-approved and successfully integrated into cardiac and urologic surgery. Patients are reaping the benefits with decreased bleeding, less pain, and are abl...

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