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Tag: "tumor" at biology news

Gene Vaccine Protects Mice Against Development Of Her2/neu Breast Cancer

...ine. Researchers thenimplanted a HER2/neu-positive tumor into mammary tissue in the mice.All of the control mice developed breast cancer but only one mouse ineach of the VRP-neu groups did. In short, 86 percent of mice thatreceived the vaccine were protected against the cancer. The experimentwas repeated n...

A comprehensive response to HIV could prevent 10 million AIDS deaths in Africa by 2020

...ine. Researchers thenimplanted a HER2/neu-positive tumor into mammary tissue in the mice.All of the control mice developed breast cancer but only one mouse ineach of the VRP-neu groups did. In short, 86 percent of mice thatreceived the vaccine were protected against the cancer. The experimentwas repeated n...

UCLA scientists transform HIV into cancer-seeking missile

...revents the drug from taking effect and allows the tumor to continue growing unchecked." In order to track...may be able to boost immune-system surveillance at tumor sites, identify cancer cells' exact location and kill them before they cause damage," he added. "Bey...

Estrogen-like Component of Plastic Stimulates Growth of Certain Prostate Cancer Cells

...onwhether the synthetic pseudo-estrogen encourages tumor growth in wholeanimal systems.“We’ll know more abo...contending that it may promote the growth of human tumor cellsand alter the growth and development of animals....

Novel ultrafast laser detection of cancer cells also may improve understanding of stem cells

...real-time, high-throughput identification of liver tumor cells at their earliest stages, and without invasive chemical reagents. The technique generates a laser beam in single human cells pumped from a flask through tiny microchannels. The beam is altered by what it encounters. These changes, registered b...

New RNA polymerase discovered in plants

...developmental problems, from dwarfing in plants to tumor development in humans to certain death in mice. Pikaard thinks that Pol IV helps make siRNAs that then direct DNA methylation to sequences matching the siRNAs. The results were published in Cell online, Feb. 10, 2005 and will appear in the March, 2...

Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer

...thology as seen in human colon cancers and develop tumor growths called polyps in their colons, eventually ...eveloped tumors, however, in the absence of Foxl1, tumor frequency was more than 7-fold higher. In addition, the animals developed tumors in the stomach. No...

TEL2 gene cooperates with MYC gene to provoke B-cell lymphomas

...omas over-express the MYC gene, either because the tumor cells acquire additional copies of this gene or because the cells suffer mutations that affect control over the level of MYC expression. Excess MYC expression spurs the cells to proliferate. This abnormal behavior then triggers p53 to instruct these ...

New Treatment Rivals Chemotherapy For Lymphoma, Study Finds

... are used to assess how quickly Bexxar reaches the tumor and how quickly the radiation disappears from the patient's body. One to two weeks after that initial dose, the patient then receives a custom-tailored therapeutic dose, and therapy is considered complete. The most common side effect is a temporary l...

Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin

... molecules have enabled researchers to visualize a tumor more than one centimeter below the skin surface us... of a polymersome, a cell-like vesicle, to image a tumor within a living rodent. Their findings, which represent a proof of principle for the use of emissive...

Expression Project for Oncology (expO) completes first phase of standardized gene expression analyses

...inically annotated gene expression profiles for 60 tumor specimens, completing the initial phase of the nat...yses on a clinically annotated set of deidentified tumor samples updated with clinical outcomes and release all data into the public domain without intellect...

Potential treatments for neurofibromatosis

...cause inflammatory cells play an important role in tumor formation in these malignancies." Neurofibromatosis results from mutations in a gene called NF 1. In humans, NF 1 mutations resulting in neurofibromatosis occur in one in 4,000 births, equally affecting both sexes and all races and ethnicities. It i...

Use of PET can reduce, may eliminate more strenuous drug development trials with animals

...so investigating the effect of cancer therapies on tumor function and performing cardiac studies that explore drugs that reverse the conditions of animals. The JNM articles on small animal imaging, with numerous SNM members as authors, are listed here. * Welch's co-author of "Preparation, Biodistribu...

New drug shows promise as powerful anticancer agent

...ction of a critical molecule that is required by a tumor cell to complete cell division," explains lead aut... examined the effects of Plk1 inhibitor ON01910 on tumor growth in several animal models. The researchers found that ON01910 arrests cell division in a varie...

Scientists identify molecule that regulates well-known tumor suppressor

...mors through negative regulation of the well-known tumor suppressor, PTEN. The research, published in the M... and survival, and is inhibited by activity of the tumor suppressor PTEN. Research indicates that PTEN exerts its tumor suppressor activity by inhibiting PKB...

Nanoparticles offer new hope for detection and treatment

... is you have the ability to focus more drug at the tumor site, so the dose at the site might be ten to a th...cause a doctor could use them to discern whether a tumor was still growing after radiation or chemotherapy treatments. Although this study focused on melano...

Buying Time Through Hibernation on Demand

...the normal cells long before we're killing off the tumor cells. By inducing metabolic hibernation in healthy tissue we'd at least level the playing field," he said. The delivery of such treatment could be as simple as an intravenous infusion of saline solution mixed with trace amounts of an agent that woul...

U-M team recovers ancient whale in Egyptian desert

...the normal cells long before we're killing off the tumor cells. By inducing metabolic hibernation in healthy tissue we'd at least level the playing field," he said. The delivery of such treatment could be as simple as an intravenous infusion of saline solution mixed with trace amounts of an agent that woul...

Medical molecules designed to respond to visible light that can penetrate tissue

...utical compounds that can cleave DNA, such as in a tumor cell. "The challenge has been that tissue blocks light so we can't signal molecules deep within the body to deliver drug therapy," says Brewer, associate professor of chemistry. Matthew Mongelli of Maywood N.J., a postdoctoral associate in chemistry...

Harmful chemicals may reprogram gene response to estrogen

...hat the DES exposure enabled estrogen to drive the tumor development when combined with a genetic predisposition." While DES exposure can lead to the development of vaginal and cervical cancers, the fact that most DES-exposed women did not develop the cancers suggests that genetic predisposition is an imp...

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