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Tag: "tumor" at biology news

Single microRNA causes cancer in transgenic mouse

...leads to cancer. Others, however, behave more like tumor suppressors, because they block genes that keep abnormal cell division in check or induce prolonged survival. Our transgenic mouse model clearly shows that miR155 is an oncogene, because it leads to B cell malignancies when it is dysregulated." Alt...

Scientists discover a genetic switch that links animal growth and cancer

...eading to cancer. These brakes are proteins called tumor suppressors. Working with a tiny roundworm known ...medical science, the researchers discovered that a tumor suppressor known as PTEN also functions to keep the animal in a waiting state by blocking cell growt...

UCLA scientists uncover mechanism of response to targeted therapy

...d that human kidney cancer cells that had lost the tumor suppressor gene Von Hippel Lindau (VHL) were more ...erapies because it "in kidney cancer, it stops the tumor cells from growing, it doesn't kill them." It could be paired with conventional chemotherapy or with...

How can we protect patients with weakened immune systems from influenza?

... dedicated to children with neuroblastoma, a solid tumor of the peripheral nervous system, who are treated with a novel type of stem cell transplant. Both chemotherapy and stem cell transplants involve suppressing the patients' immune defenses. A third group of patients has chromosome 22q.11.2 deletion syn...

Macrophage signaling may affect hormone resistance in prostate tumors

...evel that, when the immune cells interact with the tumor cells, the result essentially negates the effect o...xternal signaling from macrophages in the prostate tumor microenvironment might affect hormone resistance.Using cell biology methods, they discovered a mecha...

New test to detect rare proteins in blood

... the Her2/neu molecule is shed from the surface of tumor cells and has been detected in the blood of breast...ible to detect tumors at very early stages so that tumor emergence or reoccurrence can be rapidly treated or even prevented. Greene's laboratory established...

Tumor cells that border normal tissue are told to leave

The thin, single-cell boundary where a tumor meets normal tissue is the most dangerous part of ... Medicine in St. Louis. The researchers found that tumor cells bordering normal tissue receive signals that tell them to wander away from the tumor, allowing...

Genome changes tracked during multiple myeloma initiation, progression and treatment

...large number of yet-to-be-discovered oncogenes and tumor suppressor genes. These amplification and deletion patterns define new disease subgroups of MM that are characterized by varied dysregulation of distinct cancer-relevant genes and can be correlated with different clinical outcomes. Importantly, sever...

Growth factor-promoting angiogenesis expressed in tumor cells and normal neurons

...hat a stem cell factor overexpressed both in brain tumor cells and in neurons following brain injury promotes tumor survival by inducing angiogenesis. The research study, published in the April issue of Cancer Cell, ...

'Shuttling' protein possibly key to resilience of cancer cells

...e done using a line of "teratocarcinoma" malignant tumor cells from mice called F9, which, when subjected to the right biochemical signals, have the ability to alter their properties and are considered to be "cancer stem cells." The hypothetical cancer-resistance role of cancer stem cells could explain why...

Loosen leash on cancer protein 'watchdog,' researchers say

... for developing cancer showed a marked decrease in tumor development when compared with mice that had norma...ld increasing their levels of p53 delay or prevent tumor formation in living creatures, and would there be any negative consequences to the increase? "We we...

Nano-particles effective in killing cancer with one-two punch of chemotherapeutics

...er cells, allowing us to target these drugs within tumor cells." One key feature of molecular mechanism ...tails of paclitaxel and doxorubicin lead to better tumor regression than either drug alone, but there hasn't been any carrier system that can carry both drug...

Data published in PNAS show antibodies can be made 10 times more toxic to cancer cells

...for cancer, such as their specificity in targeting tumor cells and low toxicity. There are currently eight ...rketed treatments lack the desired potency against tumor cells, providing only incremental improvements in therapeutic success, and many development-stage an...

New Research Shows Artificial Light at Night Stimulates Breast Cancer Growth in Laboratory Mice

...use linoleic acid as a growth signal, which causes tumor metabolism and growth activity to shut down.?/p...?said Blask. “The melatonin is clearly suppressing tumor development and growth.?/p> In contrast, tests with the melatonin-depleted blood from light-expo...

Molecular force field helps cancer cells defend against attack

...d deploy a deflector shield to evade enemy attack, tumor cells are capable of switching on a molecular forc...damage from radiation or chemotherapy and promotes tumor cell survival. But in laboratory experiments, UF scientists were able to block the union, and the ma...

Stowers scientists demonstrate mechanism of vertebral formation

...here they are thought to play a role in controling tumor invasion. Understanding their function in embryonic development may provide insight into their dysfunction in cancer. Additional contributing authors from the Stowers Institute include Pascale Malapert, Lab Manager II; Jérome Chal, Predoctoral Rese...

VCU Massey Cancer Center researchers identify a new class of anti-cancer drugs based on platinum

...platin by altering its ability to effectively kill tumor cells. By understanding the features of cisplatin that contribute to resistance, Farrell and his team designed the new compound to circumvent these problems. ...

Protein found to control tumor growth in certain breast cancers

... the nearly total inhibition of estrogen-dependent tumor growth in mice, and the reduction of estrogen-indu...responses in vitro. In stark contrast, significant tumor growth occurred when Nod1 was absent. "We have greatly expanded our knowledge of the Nod1 pathway ...

Proteins stop blood-vessel and tumor growth in mice

...rrent findings show that fibulins can inhibit both tumor growth and blood-vessel formation in mice." Tumor...plugs. The researchers then injected fibrosarcoma tumor cells into mice. The tumor cells were genetically engineered to produce either fibulin 3 or fibulin ...

Common molecular 'signature' identified in solid tumors

... MiRNAs can behave like oncogenes, which promote tumor growth, or tumor suppressors, which keep potentially malignant cells in check. Croce points out that miRNA activity i...

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