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Tag: "tumor" at biology news

Viral DNA sequence a possible trigger for breast cancer

...NA in the envelope (Env) protein of a mouse breast tumor virus (called MMTV) can transform breast cells into cancer cells, according to a study by Katz et al. in the February 7 issue of The Journal of Experimental Medicine. The ability of this motif to transform cells single-handedly suggests that viral in...

Jump-starting T Cells In Skin Cancer

...treated in some cases by vaccinating patients with tumor proteins. How these vaccines work and why they are... discovered that that these cells mostly recognize tumor proteins that were not contained in the vaccine. Understanding the characteristics of the T cell pop...

Source of molecular triggers in cutaneous T cell lymphoma identified

... the source of the signal: the protein products of tumor viruses, of mutated genes, and of normal but usually inactive genes. The study reports that CTCL develops from a small subset of lymphocytes that are pre-programmed to respond to self-antigens exposed during normal cell death. As cells undergo the p...

Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer

...elative contributions of the two types ofdamage to tumor formation is critical for the development of therapiesthat could help prevent skin cancer. Moreover, CPDs and 6-4PPs haveparticular potential to cause lasting damage to mammalian cells becausephotolyases ?a class of enzymes capable of efficiently rep...

It's not all genetic: Common epigenetic problem doubles cancer risk in mice

...t a cancer-causing genetic mutation will trigger a tumor there. Roughly 10 percent of people have this doub... differences to influence progression -- whether a tumor would grow slowly or quickly, or whether it would spread," says Feinberg. "But, in this case, our re...

New, automated tool successfully classifies and relates proteins in unprecedented way

...re you mightwant to identify and disable part of a tumor cell's machinery needed toprocess proteins for cancer growth."Our tool represents a step forward because it is based on standardizedfeatures and not on features chosen by the human eye, which isunreliable. By automating the clustering of proteins ins...

New binding target for oncogenic viral protein

The DNA tumor virus simian virus 40 produces the Large T antigen... 30% of human tumors. "Fbw7 is itself an important tumor suppressor which makes it an attractive choice for inactivation by Large T," explained Dr. Markus We...

Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible

...nes are turned on or off) for the same set ofhuman tumor tissues. Overall, the expression profiles of porti...y to compareresults between labs. Twelve different tumor tissues, five cancer celllines, and five purified RNA samples were prepared, blinded, andrandomized ...

U-M scientist to talk about tissue engineering at AAAS

... a large wound, like that created when a cancerous tumor is removed from the jaw, that often means taking a bone graft from someplace like the hip. That approach has problems both for the wound at the donor site and for the site where it is implanted. In addition to discussing the sometimes-messy real wor...

Genome-wide mouse study yields link to human leukemia

...ery special mice, scientists have discovered a new tumor suppressor gene and a unique chemical signature im...tify a particular stretch of DNA, called Id4, as a tumor suppressor gene. Tumor suppressor genes help control cancer by identifying and getting rid of defec...

Found: Missing sequence of the human Y chromosome

...ed insex-associated height differences and gonadal tumor development. Thispericentromeric gap was one of the few holes remaining in the"finished" sequence of the human genome reported last October by theInternational Human Genome Sequencing Consortium. This "finished"sequence was the culmination of a 13-y...

Yale Scientists Find MicroRNA Regulates Ras Cancer Gene

...lications as we continue to focus on the causes of tumor development," said Richard L. Edelson, M.D., director of Yale Cancer Center. Other Yale researchers were Steven M. Johnson, Helge Grosshans and Kristy L. Reinert; collaborators at Ambion, Inc. included Jaclyn Shingara, Mike Byrom, Rich Jarvis, Angie...

Mouse brain tumors mimic those in human genetic disorder

...he human condition and provides unique insightinto tumor development, diagnosis and treatment, according to...this same gene.Their latest paper shows that brain tumor formation in these mice hasseveral of the same distinguishing clinical characteristics as tumordevel...

New imaging method gives early indication if brain cancer therapy is effective, U-M study shows

... the course of brain cancer regimen if a patient's tumor will shrink, a new study shows. Researchers at th...rom the start of therapy to three weeks later. The tumor cells block the flow of water, so as those cells die, water diffusion changes. In the study of 20 p...

BRCA1 causes ovarian cancer through indirect, biochemical route

...gy. "Before, we thought this gene was a classical tumor suppressor," says Louis Dubeau, professor of patho...id not arise in granulosa cells. Instead, when the tumor cells were analyzed, they were found to be epithelial cells very similar to those found in human ova...

Purdue proves concept of using nano-materials for drug discovery

... pumps that quickly remove chemotherapy drugs from tumor cells, making the treatment less effective. Cancer cells exposed to chemotherapy drugs produce a disproportionately large number of the pumps, causing the cells to become progressively more resistant to anticancer drugs. Engineers and scientists in ...

Researchers identify target for cancer drugs

... and promotes cell division, often contributing to tumor growth as a result. However, as long as it stays w...activate it, thereby enabling Akt to contribute to tumor growth. "When a cell loses PTEN through, say, a mutation, Akt goes gangbusters," says Sabatini. The...

Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease

... that regulate these genes can suppress or enhance tumor growth," Bernstein notes. "Some of the genes can cause cancer directly when altered by mutations." "The work we're doing now is very fundamental," he says. "But what we learn about the interactions between chromatin, its tags, and various proteins t...

U-M scientists find genes that control growth of common skin cancer

...st common form of cancer ?anduncovered a subset of tumor cells that were resistant to inhibition ofthe Hedg...hen Dlugosz and colleaguesturned Gli2 off, the BCC tumor cells stopped growing and wereeliminated by a programmed cell death process. These results areconsis...

First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers

...eading throughout the body, while ignoring primary tumor cells, could someday give doctors a whole new weap...ad the luxury of time, we could treat that primary tumor at lower doses, too, with fewer side effects for the patient," Dr. Huang said. Until now, agents th...

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