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Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats

...ncer at Dana-Farber. "It offers the opportunity to try to understand what makes these fatty acids so deleterious, and what we need to avoid." Moreover, it is possible that in the future, drug therapy might be used to "turn down" the mechanism, decreasing cholesterol levels and heart disease risk, explai...

Current human embryonic stem cell lines contaminated UCSD/Salk team finds

...efforts have been made during thelast few years to try to eliminate any animal-derived culturecomponents in human stem cell culture. However, many of the specializedmedia used for growth and differentiation still contain materials fromanimal sources and are hence contaminated with Neu5Gc.In addition to u...

Elusive HIV shape change revealed; Key clue to how virus infects cells

...We can now compare the bound and unbound forms and try to understand whether there are any immunologic properties that differ and that might provide a route to new vaccine or drug strategies," Harrison says. ...

Learning to fight an adversary that won't stay down

...ant strains," he says. "But the clinicians rightly try to keep these things in reserve for when they are really needed." ...

Weill Cornell Research Reveals Secrets Of Trafficking Within Cells

...going to go beyond looking at clathrin per se, and try and investigate other players in the endocytotic process," he said. ÒWe're going to ask questions such as, 'OK, if I tweak this molecule, how does that change clathrin's role in all of this?'Ó "It's really quite exciting," Dr. Ryan said. "This new m...

Researchers trace evolution to relatively simple genetic changes

...occurs in natural habitats. "Our motivation is to try to understand how new animal types evolve in nature," said molecular geneticist David M. Kingsley, a Howard Hughes Medical Institute investigator at the Stanford University School of Medicine. "People have been interested in whether a few genes are i...

Octopuses occasionally stroll around on two arms, UC Berkeley biologists report

...occurs in natural habitats. "Our motivation is to try to understand how new animal types evolve in nature," said molecular geneticist David M. Kingsley, a Howard Hughes Medical Institute investigator at the Stanford University School of Medicine. "People have been interested in whether a few genes are i...

Studies reveal methods viruses use to sidestep immune system

...ntify parts of the pathway to target with drugs to try to limit infection." Drugs called protease inhibitors currently are used to treat patients infected with HIV and have also shown promise in treating hepatitis C patients in experimental trials. "We now know that treating patients with a protease in...

Gene vaccine for Alzheimer's disease shows promising results

...cal Inventions andinternal medicine. "We wanted to try a DNA-based genetic vaccineinstead to see if we could enhance the immune response."Although prior studies of amyloid protein vaccination had shown someslowing in the plaque buildup, negative side effects also occurred in ahandful of patients. Some ha...

Scientists identify molecular events that drive cell senescence

...cal Inventions andinternal medicine. "We wanted to try a DNA-based genetic vaccineinstead to see if we could enhance the immune response."Although prior studies of amyloid protein vaccination had shown someslowing in the plaque buildup, negative side effects also occurred in ahandful of patients. Some ha...

Falling ants glide back to trunk to avoid dangers of forest floor

...tially noted, they just make a 180 degree turn and try again ?usually with success. What allows the ants to change direction so quickly is still a mystery. They have long, slightly flattened hind legs which, when combined with abdominal movements, might allow the ants to reorient in midair. They also ha...

Sexual cooperation: Mating increases longevity in ant queens

...ctive biology for many animal species. Males often try to manipulate their female mates during copulation--for example, by traumatic inseminations (as in the case of bed bugs) or by the transfer of toxic seminal fluids (as in the case of the fruitfly Drosophila). These manipulations are beneficial to mal...

Protein offers way to stop microscopic parasites in their tracks

...n Sibley's lab, Fabien Brossier, Ph.D., decided to try to use the recently completed Toxoplasma genome to search for the protein that lets the parasite detach glue spots at the back of the belt. Scientists led by the Institute for Genomic Research in Rockville, Md., posted the completed Toxoplasma genome...

Polymers with copper show promise for implanted sensors

...king on this problem about eight years ago, was to try to mimic what occurs in the human body to prevent clotting on the walls of your own blood vessels," said Meyerhoff. "Your endothelial cells---the cells that line all of your blood vessels---generate nitric oxide. The nitric oxide produced in this lay...

GeneNotes - A novel information management software for biologists

...y! GeneNotes is one of them; I didn't have time to try it yet, but it seems like it could help. Nothing r...a step in the right direction. I encourage you to try it and share your experience in the forum (if you don't want to register) or in the comments sec...

Mystery Blood Vessel Disorder Implicated In 'Mini' Strokes

...ow the patients in this study (the GENIC study) to try to determine which vascular or genetic factors contribute to the syndrome. They will also attempt to replicate their MRI data in an autopsy study of patients who died with dolichoectasia. ### Article: "Intracranial Arterial Dolichoectasia and Small...

Scientists journey to southern Africa to unravel the secret world of elephant communication

...kert pay close attention to the wildlife below. "I try to get a good count of the elephants as they come in and a good view with the video camera," Eckert says. The upper level served as command central for the four-week experiment--a high-tech headquarters crammed with laptops, cameras, cables and reco...

Double triumph in stem cell quest

...insky's method, federally funded researchers could try to derive stembrids using already-approved ESC lines. Verlinsky still has a lot to do to convince others of his claims, however. Marilyn Monk, an embryologist at the Institute of Child Health in London, summed up the general feeling afterwards: "It ...

Scientists discover that three overlapping signals in embryo help get the backbone right

...fate of the embryo. Khokha and Harland decided to try blocking more than one, and chose to work in embryos of the frog Xenopus tropicalis, a close relative of the more common laboratory frog Xenopus laevis. X. tropicalis is easier to work with, because it, like humans, is diploid, that is, it has only t...

Oceans more vulnerable to agricultural runoff than previously thought, study finds

...e sea. "There has been an international effort to try to understand the productivity of the oceans and their potential vulnerability to nitrogen," said Pamela A. Matson, the dean of the School of Earth Sciences and co-author of the Nature study. "A map has been developed showing special regions in the w...

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