Radiation-killed bacteria vaccine induces broad immune response in mice
...he cold chain is rarely a problem. The same is not true in less developed countries. Vaccines made from whole, irradiated bacteria, freeze-dried into an easy-to-transport powder, could be reconstituted just before use, explains Dr. Raz, thereby eliminating the cold chain requirement. It is also possib...Tamoxifen for breast cancer prevention does not benefit most women
...ncer reaches 3 percent or more. This is especially true for women who have not had a hysterectomy, and therefore face the risk of endometrial cancer related to tamoxifen use. Cost-effectiveness was also calculated in the study. For women at the 1.67-percent risk level, taking tamoxifen to stave off brea...Mechanism identified for promising neurological drug
...ock DNA repair," he cautions. "That will likely be true of minocycline. And in blocking DNA repair you conceivably increase the risk of cancer. In clinical trials where people are taking minocycline for months at a time, I think that investigators need to take this into consideration ?although for someone......he researchers want to know if their findings hold true in different environments around the world. "To understand how important something is, you have to test in multiple locations," Whitham said. A parallel study in Australia that examines the eucalyptus tree as the foundation species is yielding the s...Cigarette smoke blocks cell repair mechanism, University of Florida study shows
...e of these cells that survive are really acquiring true mutagenic characteristics," Narayan said. "A defect in only one cell is important for growth of a full-blown tumor. You don't need 1,000 or 1 million cells to be affected. Only a single cell which may have genomic instability due to compromised DNA r...Agriculture and tropical conservation: rethinking old ideas
...ttle pastures. So the standard litany doesn't ring true to them." Vandermeer and Perfecto reviewed studies of biodiversity in the Atlantic coast rainforest of Brazil, a region that is unusual in having areas of tremendous biological variety adjacent to highly developed, industrialized areas. "The are...Basic work on E. coli identifies two new keys to regulation of bacterial gene expression
...est whether their findings in model organisms hold true in other species, says Gourse, who studies a strain of E. coli that while harmless, is closely related to disease-causing varieties like E. coli 0157:H7. "Basic research in E. coli is very important," says Gourse. "Much of what we know about gene ...Carnegie Mellon researchers discover key deficiencies in brains of people with autism
...ies of sentences to determine whether each one was true or false. The sentences either had high imagery content ("The number eight when rotated 90 degrees looks like a pair of eyeglasses") or low imagery content ("Addition, subtraction and multiplication are all math skills.") The findings confirmed th...Gene therapy injected into the brains' of mice with Huntington's disease
...imer's disease patients. The vector is no longer a true virus as it cannot replicate on its own and no longer contains any of its own genes. The vector has been engineered to transfer the gene for the brain nutrient selectively to the area of the brain where it is needed to protect the degenerating cells....Methane-belching bugs inspire a new theory of the origin of life on Earth
...to be the direct descendant of one of the earliest true microbes. "We know that this bug is very ancient indeed," Ferry told the Penn State Astrobiology Research Center's annual meeting earlier this week. "There is strong phylogenetic evidence that acetate kinase is a very ancient enzyme." No such evidenc...In drug design, a loose fit may be best bet
...ctive its cellular signaling. If the findings hold true for similar hormone-receptor reactions, they could help change the way that drug therapies are designed for a host of health problems, from smell and taste disorders to heart disease, asthma, migraine, and pain. The study is published in the May 12, ...Pollutant haze heats the Arctic
...o outer space," Garrett says. "The reason this was true is that the pollution particles made the cloud droplets more numerous, but consequently smaller. Even if the amount of water is the same in the cloud, a larger number of small droplets corresponds to a more effective blanket." People living in Salt...Just like us, social stress prompts hamsters to overeat, gain weight
...more than consecutive (predictable) defeats, as is true in humans? An uncomfortable situation To answer these questions, the researchers placed an 11-week-old hamster (the subordinate intruder) into the cage of an older and larger hamster (the dominant resident). The intruder remained in the aggresso...Newborn screening can cause unnecessary parental stress
...e correct reason had reduced stress. (This was not true for fathers, however.) Other findings: Some pa...e are at least 12 false-positive results for every true case diagnosed*; another puts the ratio at more than 50:1.** ...Study challenges myth that sex late in pregnancy hastens birth
...abor and delivery. In fact, just the opposite was true in 93 women studied at Ohio State University Medical Center. Women who were sexually active in the final three weeks of their pregnancies carried their babies an average of 39.9 weeks, compared to average delivery at 39.3 weeks among women who abstai...Genetic 'roadmap' charts links between drugs and human disease
...ones, too." Like other scientific databases, the true value of the Connectivity Map lies in its capacity to be queried by nearly any researcher with a computer. The genomic signature of a particular human disease, drug or other biological response of interest serves as the search "word" and potential fu...What animals can tell us about hemorrhage, organ transplants and aging
...during this time. And Carey has found that this is true even when the hibernating squirrel briefly arouses from hibernation during the winter and its physiology has returned to normal. These findings could one day extend the time we can preserve organs for transplant and give doctors time to find a suit...Killing brain tumors from within: A 'Trojan horse' approach
...n the tumor cells, it destroys them from within ?a true "Trojan horse," said Prof. Levitzki. Normal cells, which possess 20 to100 less receptors for EGF, are spared, since the amount of double-stranded RNA gobbled up is insufficient to induce them to die. The lethal RNA approach has been applied to ...Halving daily cigarette quota has no health benefit
...back compared with heavy smokers. But this was not true of women who cut back, where the reverse was true. And men who cut back only had slightly lower death rates from all causes combined than the heavy smokers during the first 15 years. After that, death rates were comparable. And there were no si...UGA scientists unravel 'molecular inch-worm' structure of walking-pneumonia bacterium
...can Krause, leader of the research team. "They are true minimalists with very small genomes, lacking the typical cell regulatory mechanisms found in other bacteria. And yet some species such as M. pneumoniae posses this complex terminal organelle. We've been able to observe it in growing cultures and desc...