New cellular flaw found in some virulent breast cancers
...itute have identified a molecular interaction that triggers a particularly aggressive form of breast cancer, and suggest that attacking this target with selective drugs might improve treatment. In the January issue of Cancer Cell, a team led by Qunyan Yu, MD, and Peter Sicinski, MD, PhD, of Dana-Farber repo...Growing crops to cope with climate change
...long enough CO activates one of the key genes that triggers flowering. Naturally occurring variation in Ppd-H1 affects the time of day when CO is activated. This shifts the time of year that the plant flowers. Dr David Laurie, the research leader at the John Innes Centre, said, "Growing crops will become mor...A surprising pair of proteins help make healthy eggs
...found that in the granulosa cells of the ovary, it triggers production of another protein, called c-Jun, and together they switch on a network of ovarian genes that help promote granulosa cell proliferation. "The big surprise was c-Jun," Freiman said. That's because this well-studied protein is found at hig...Red Tide causes sea turtle die-off in El Salvador
...nd sewage from urban areas have been postulated as triggers for these events. ...Tiny polyps gorge themselves to survive coral bleaching
... and stays there for more than two weeks or so, it triggers a bleaching event. Once that happens, the symbiotic algae and the brown or green photosynthetic pigments inside are lost. The result is a "bleached" white coral. "In most cases, corals get 100 percent of their daily metabolic energy needs from the ...Wisconsin scientists discover a master key to microbes' pathogenic lifestyles
...ar sensor embedded in the spores of the fungi that triggers the transformation. The finding is reported in the April 28 edition of the journal Science. The discovery could lead to new treatments, and possibly vaccines for the diseases caused by these Jekyll and Hyde microbes, says Bruce Klein, a UW-Madison p...Infection 'alarm' yields clues to immune system behavior
...ein molecule called tumor necrosis factor, or TNF, triggers an immune response, were reported in the February .... (This is in contrast to a systemic response that triggers an immune reaction throughout the body, causing a fever. If the immune system responds too aggressiv...Duke to test bird flu vaccine dosing
...flu vaccine to determine whether the vaccine still triggers a strong immune response at lower doses. The seven-month trial is sponsored by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health. Also participating in the study are the University of Maryland, the Unive......at bits of the brain are lighting up but also what triggers it to light up and when. In this test, the important thing was to find out whether brain activity before an event has an impact on memory or whether, as was previously thought, it's just brain activity after an event that is important for memory. W...Depression model leaves mice with molecular scar
...Our study provides insight into how chronic stress triggers changes in the brain that are much more long-lived than the effects of existing antidepressants," explained Nestler. Mice exposed to aggression by a different dominant mouse daily for 10 days became socially defeated; they vigorously avoided other ...The secret love life of plants
...ingle fertilisation, which creates an embryo, also triggers the development of endosperm, even when the central cell where endosperm develops is not fertilised.The ovules of flowering plants are housed in a carpel. Pollen lands on the flower's stigma and forms a pollen tube. It then uses each one of its two s...A resetting signal keeps circadian rhythm on track in Drosophila fruit flies
... morning cells. In other words, the evening clock triggers the alarm at its own pace, but it is the morning clock which sets the alarm every day. "So if you are looking over several days, only one period will be observed ?the one dictated by the morning clock," Stoleru said. Research by the same Brandei...Worms know bad food when they smell it
..., which sends a serotonin signal to the brain that triggers nausea. "People who are getting chemotherapy are told 'eat only bland foods -- don't eat foods you really like because you won't be able to eat them again,' because you'll have this learning experience," Bargmann said. ...Blocking the nerve receptor EP1 in mouse models reduces brain damage caused by stroke
...ve discovered how to block a molecular switch that triggers brain damage caused by the lack of oxygen during a...cientists showed that stimulation of EP1 receptors triggers the damage caused when blood flow is suddenly restored after a stroke. The team blocked blood flow i...Breaking the mold: Research teams sequence three fungus genomes
...most common mold causing infection, A. fumigatus triggers allergic reactions, asthma attacks--and even deadly infections among people with weakened immune systems. Now, in the December 22 issue of the journal Nature , scientists at The Institute for Genomic Research (TIGR) and their collaborators report ...Scientists map one of biology's critical light-sensing structures
...d bolts" of how the photoreceptor senses light and triggers a series of downstream events that control growth and development, according to Katrina Forest, the other senior member of the team and a UW-Madison professor of bacteriology. "There were some surprises," says Forest of the ribbon-like protein. "This...Researchers know what you were about to say; fMRI used to detect memory storage and retrieval
...we think back to the past, each detail we remember triggers another, until the memory returns completely," Polyn said. "In that sense, memory retrieval is like revisiting the past; brain patterns that are long gone can be revived by the memory system." ...Scientists observe how a close bond activates the immune system
...'s soldiers, T cells, are called into action. What triggers this complex response begins when T cells and dendritic cells, another type of immune cell, form a kind of molecular embrace, or immunological synapse, to relay information about intruders. The communication between these immune cells hasn't been w...Computer models aid understanding of antibody-dependent enhancement in spread of dengue fever
... immunity to the virus. Enhanced virus replication triggers a more deadly, hemorrhagic form of the disease. A study published in the online edition of Proceedings of the National Academy of Sciences suggests that antibody-dependent enhancement offers an evolutionary trade-off between advantage and disadvant......rby Marine Biological Laboratory, to find out what triggers the organisms to reach concentrations that become deadly, and whether that threshold varies among clam strains. Smolowitz uses traditional microscopic examination of tissues to determine if clams are sick. Gast's genetic test can now also be used ...