Mouse study reveals new clues about virulence of 1918 influenza virus
...ong these insights, they found that the 1918 virus triggers a hyperactive immune response that may contribute to the lethality of the virus. Furthermore, their results suggest that it is the combination of all eight of the 1918 flu virus genes interacting synergistically that accounts for the exceptional vir...Researchers discover how bacteria sense their environments
...gar in its environment, communication of some sort triggers an array of linked receptors to rearrange itself, much like when water freezes, all the water molecules assort themselves into a new structure. Through this reorganization, the bacterium's receptor array amplifies the signal that a specific molecule ...New treatment for food poisoning
...uses the food-borne disease, listeriosis. It often triggers a brain infection and kills up to 30% of those affected. To test whether antibiotics are effective, bacteria are taken from patients and tested in the laboratory. These tests measure whether antibiotics can halt the growth of Listeria in laboratory...Smokers invite to test vaccine against nicotine addiction
... carried by the bloodstream to the brain, where it triggers neuro-receptors to generate positive sensations that can lead to addiction. The vaccine stimulates the immune system to produce antibodies that recognize the small nicotine molecule. Bound to these antibodies, nicotine molecules no longer can cross t...AIDS vaccine research offers new insights on survival
...o control. Attempts to develop an HIV vaccine that triggers the production of antibodies -- the mechanism responsible for vaccine protection against other viruses including polio and hepatitis B -- have been unsuccessful. "HIV mutates so quickly it can evade antibody immunity," explains Letvin. Instead, Letv...Lack of key enzyme associated with development of rare tumor
...logous to how a key fits into a lock. This action triggers the cell to produce substances known as cyclic nucleotides. These function as "second messengers," often stimulating the cell to begin an activity. In the case of adrenal cells, cyclic nucleotides, such as cyclic AMP and cyclic GMP, may stimulate c...Pollen proves beneficial for northern lakes
Mention the word pollen to most people and it triggers thoughts of their battle against allergic reactions. However, a University of Alberta researcher has found an important spin-off for this fine yellow dust-like powder. Mark Graham, a PhD student from the Department of Biological Sciences at the U ...A single sugar found responsible for an antibody's ability to treat inflammation
...unology, was struck by this inconsistency. "If IgG triggers autoimmune disease, how could it be pathogenic and therapeutic?" he asked. "We call it the IgG paradox." Six years ago he started an investigation into exactly how IVIG worked, and what he's discovered could one day lead to a whole new class of thera...WWF captures first-ever photo of wild rhino on Borneo
...y. Camera traps are remotely activated by infrared triggers when animals walk by. "These are very shy animals that are almost never seen alive in the wild," said Matthew Lewis, Program Officer for WWF's Species Conservation Program. "The photos we get from the camera traps will eventually give us a better id...New compound reduces stroke damage
...ed FKBP38. "High FKBP38 activity in neuronal cells triggers mechanisms leading to programmed cell death," explains Fischer. "Inhibition of FKBP38 makes cells more predisposed to survive." The scientists also synthesized a molecule that specifically inhibits FKBP38 and administered it to rats that were experi...When it comes to gene transcription, random pauses aren’t quite so random, study finds
...plates using a special 240-base pair sequence that triggers one of two types of long pauses in RNAP--a "backtracking pause" associated with gene regulation in which the enzyme reverses direction briefly; or a "hairpin pause, " named for tiny hairpin-shaped structures that sometimes form when an RNA strand bin...Genetic snooze button governs timing of spring flowers
...pidly in the spring niche." Exposure to the cold triggers a process in plants known as vernalization, where the meristem - a region on the growing point of a plant where rapidly dividing cells differentiate into shoots, roots and flowers - is rendered competent to flower. In a series of studies of Arabido...UC Davis researchers reveal apples' protective ways
...mor necrosis factor (TNF), a compound that usually triggers cell death and promotes inflammation via a mechanism called the "nuclear factor (NF) kappa B pathway." This pathway involves chemical signaling between cells. The apple extract was able to protect the cells from the normal lethal effects of TNF. "O...EGF receptor activation prevents microbes from going more than skin deep
...es from Lund University, Sweden, investigated what triggers AMP production in human skin. Interestingly, they found that AMPs were produced in human skin after sterile wounding of the skin surface, illustrating that exposure to invading microbes is not the sole trigger for the immune response in skin. The au...T cells activated to fight HIV basis for dendritic cell therapeutic vaccine
...r with CD4 T cells to release IL-12, which in turn triggers stimulation of killer CD8 cells that are specific to the virus. Reporting at AIDS 2006, Xiao-Li Huang, M.D., research assistant professor of infectious diseases and microbiology at GSPH, said that IL-12 could be increased when CD40 ligand, a substa...'Sticky' mice lead to discovery of new cause of neurodegenerative disease
...n of misfolded proteins in neurons that eventually triggers cell death. But this new mechanism points to errors in executing the genetic instructions, which are distinct from known causes of neurodegenerative diseases, such as Alzheimer's and Huntington's diseases. HHMI investigator Susan L. Ackerman and h...Case Western Reserve University researchers find protein associated with brain cell death
...dence of which protein in the brain's immune cells triggers a cascade of reactions that produces unregulated free radical production that eventually leads to the neural cell death found in Alzheimer's disease. They report their findings in the Journal of Biological Chemistry article, "Fibrillar Beta-Amylo...FSU biologists uncover mechanisms that shape cells for better or worse
...es involved in the cell-to-cell communication that triggers the development of cell polarity in Drosophila oocytes (unfertilized fruit fly eggs) also are known players in the pathogenesis of those diseases. The research performed by FSU Assistant Professor Wu-Min Deng and doctoral student John S. Poulton in...Research reveals inner workings of immune system 'thermostat'
...hey trigger their production. Wounding, in effect, triggers a healing process." In previous research, Yap discovered that mutant mice with a naturally defective tyk2 gene were immune to arthritis, a condition caused by inflammation. But these mutants were much more susceptible to opportunistic infections. W......ule underlying the formation of brain tumors. PDGF triggers such cell response by plugging into the target receptor on the stem cell, like a key inserting into a lock. There had been indirect evidence that neural stem cells give rise to brain tumors. "However, it has not been shown in vivo that tumor stem ...