trials 2 8

Tag: "trials" at biology news

Scientists discover that widely available drug also helps fight kidney disease

...ved for other uses will facilitate future clinical trials of the drug." Co-authors on the paper with Weimbs are: Jonathan M. Shillingford and Seng Hui Low in the Department of Molecular and Cellular Biology at UCSB; Claire H. Larson at the Department of Cell Biology, Lerner Research Institute, Cleveland Cl...

Aspirin reduces cardiovascular risks in men and women -- but differently

...r continued. "But now, the combined data of recent trials involving women demonstrates that women can benefi...ery disease. Of that total, 51,342 were women. The trials all involved the comparison of low-dose aspirin versus placebo for the primary prevention of cardiov...

Basic research leads to a novel cancer therapy

...cer. The studies are in various stages of clinical trials (phases I through III), and most of them are being carried out in combination with other therapies. Ullrich is very pleased with the quick approval of SUTENT®. He says, "Already before approval, 1,700 patients could be treated with the new preparati...

Anti-HIV drug has potential to prevent transmission in women

...aboratory tests while using the gel. Past safety trials of microbicides showed that certain gels caused ulcerations and inflammation in women that could actually facilitate HIV transmission. The favorable findings of the tenofovir gel's Phase I safety and acceptability trial has already led to a larger Ph...

UCLA scientists uncover mechanism of response to targeted therapy

UCLA researchers knew - based on two clinical trials - that a subset of kidney cancer patients responde...eories. Working backward from responsesin clinical trials is unusual, Thomas said. Responses observed in clinical studies led researchers back to the laborato...

High resolution 'snapshots' detail dynamics of a cocaine antibody

...ydrolyzing activity and make future human clinical trials feasible. "Given the fact that catalytic antibodies have been produced with the same levels of efficiency as natural enzymes, it seems well within the realm of possibility," he added. To reach this ambitious goal, however, it may be necessary to ex...

New test to detect rare proteins in blood

...d tumors with the same antibodies. Recent clinical trials support the notion that early treatment prevents t... ?over 10 years ago ?and more recently in clinical trials that treatment of small or incipient tumors is a way to prevent tumor emergence or reoccurrence. "Pr...

Therapeutic prospects beyond Vioxx

...not been addressed directly in any of the clinical trials of COX-2 inhibitors," says FitzGerald. "However, although these studies indicate that it would limit the cardiovascular risk, it would also be expected to add to the risk of stomach problems, undermining the reason for choosing COX-2 inhibitors in th...

New study reveals promising osteoporosis treatment

...ore studies will be needed, ultimately using human trials to confirm the results. Dr. LeGeros' paper, Effect of Mg/Zn/F-CaP Supplements on Bone Properties: Phase 1, describes initial results of her research, which is funded by a four-year, $2 million grant from the National Institute of Biomedical Imagin...

A bathroom that cleans itself

... they can absorb light at longer wavelengths. Lab trials show that glass coated with the new nanoparticles can be activated by visible light from a lamp to kill Escherchia coli. "If you've got this on tiles or shower screens you don't need so many chemical agents," says Professor Amal. So far the team h...

Resveratrol prolongs lifespan and delays onset of aging-related traits in a short-lived vertebrate

...ila. However, until now, life-long pharmacological trials were performed in the worm or fly model organisms ...ain, making large-scale, life-long pharmacological trials in mice unaffordable. Recently, a small fish species with a captive lifespan of only three months w...

New licensing agreement to maximize AIDS drug development

...e: Savvy, which is currently in Phase III clinical trials in the U.S. and Africa; UC781 which is in expanded Phase II trials in the U.S and Thailand and Cyanovirin-N which is in preclinical testing. Henry Gabelnick, Ph.D., ex...

Statins have neutral effect on risk of cancer

...e-scale, randomized, active- or placebo-controlled trials for primary and secondary prevention of coronary a...hrough July 2005 to identify randomized controlled trials of statins. They found 27 articles (n = 86,936 participants) that met their criteria for inclusion...

Data published in PNAS show antibodies can be made 10 times more toxic to cancer cells

...many development-stage antibodies fail in clinical trials due to lack of demonstrated efficacy. Scientists at Xencor, a biotherapeutics company developing protein and antibody therapeutics, said the changes it made to the antibody Fc regions increased antibody effector functions such as activation of immu...

New vaccine for condition that kills 500,000 children a year

... one of the largest pre-licensure vaccine clinical trials ever conducted worldwide, research championed by an Eastern Virginia Medical School investigator demonstrated that the oral vaccine Rotateq virtually eliminated the most severe cases of rotavirus, a common childhood virus that sometimes becomes deadl...

All placebos not created alike

...While researchers usually use placebos in clinical trials to test the effectiveness of a new treatment, this...at will explore the placebo phenomenon in clinical trials for different illnesses and in laboratory experiments that focus on underlying neurobiological, bioc...

Study indicates dramatic rise in antibiotic-resistant community-acquired staph infections

...and hope other scientists might implement clinical trials to definitively determine which antibiotic agents work best for the treatment of community acquired MRSA infections. In the meantime, the CDC's fact sheet on MRSA suggests that preventing MRSA may be as simple as employing the tried and true cure of...

Free-radical busting antioxidants might not promote healthy hearts

...help explain the disappointing results of clinical trials with other free radical-scavenging antioxidants, such as Vitamin E, which have shown no protective effect against heart disease in humans. The protective effect of these compounds depended on the induction of a cellular enzyme called heme oxygenase-...

Stem cell transplants improve recovery in animal models for stroke, cerebral palsy

... Adminstration with the goal of beginning clinical trials within the next few years. In preparation for potential clinical use, the researchers are pursuing transplants in larger animal models and studying how MultiStem TM cells work in living human brain tissue housed at the MCG Human Brain Bank, direct...

Taipan venom no snake oil

... based on Factor X is being evaluated for clinical trials by bio pharmaceutical development company QRxPharma. "Australian snakes literally have a two-pronged attack when they bite their prey," Dr St Pierre said. "Firstly, venom injection causes massive blood clots instantaneously followed by paralysis as...

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