trials 2 7

Tag: "trials" at biology news

Enzyme inhibitors block replication of SARS virus

...tudied Lopinavir and are preparing it for clinical trials against SARS. Researchers in Wong's lab at Scripps Research and in Taiwan have been looking at other Liponavir-related compounds for similar blocking effects. During these experiments, they found that a group of catalyzing agents used to help promot...

Mouse study reveals human X-SCID gene therapy poses substantial cancer risk

...wn as the "bubble boy" syndrome ?in small clinical trials being conducted in France, the United States, the United Kingdom, and Australia. Although replacement of IL2RG can cure X-SCID, the Salk scientists urge caution in the use of such therapy on the basis of their new findings. "We were surprised by th...

Low-cost drug gaining favor for use in HIV-infected children in poor countries

...g both the content and quality of existing medical trials on a topic. To be included in the Cochrane findings, a study had to be a randomized clinical trial. Grimwade's search turned up only one trial that passed that litmus test: a study of 534 HIV-positive children in Zambia. The study found 33 percent ...

Researchers reverse juvenile diabetes in animal model

...death. "We are very excited to begin the clinical trials and see if this process will work in patients with type 1 diabetes," said Dr. Trucco. "A type 1 diabetes diagnosis can be devastating for children and their families. We hope this trial will have results that are life-altering for patients who suffer...

New drug could reduce tissue damage after heart attack

...lable, it should be possible to undertake clinical trials of CRP inhibition within a couple of years. If the treatment proves safe and effective, we also aim to investigate its effectiveness in strokes. "It is likely that CRP contributes to tissue damage in a range of diseases in which CRP levels are grea...

Melanoma vaccine strategy shows promise in laboratory experiments

...vaccine, and we hope to move toward human clinical trials as soon as possible." A substantial proportion of melanoma patients, about 50 percent, have killer T cells able to recognize the BRAFV600E peptide. Combining the prevalence of the peptide among melanoma patients ?about 70 percent ?with the number of...

'Uniquely human' component of language found in gregarious birds

...rom the finite-state set. After 10,000 to 50,000 trials over several months, 9 of 11 tested starlings learned to distinguish the patterns. The birds were not simply memorizing particular sequences of rattles and warbles they could distinguish between different patterns even when presented with entirely ne...

Human albumin from tobacco plants

...ve, the more albumin we can get". To date all the trials undertaken with tobacco plants have been with laboratory varieties. The aim is to do tests with commercial varieties. Laboratory plants are very small and, as a result, the quantity of albumin extracted is not sufficient. However, the commercial vari...

Boosting newborns' immune responses

... as neutrophils. Based on this discovery, clinical trials are now underway at the University of Texas Southwestern Medical Center in Dallas to replace the missing BPI in high-risk newborns with heart conditions who are undergoing cardiac bypass operations. "As we better understand the molecular pathways th...

Evidence for omega 3 fats less conclusive than we thought, say experts

...hers analysed 89 studies (48 randomised controlled trials and 41 cohort studies) to assess the health effect...mportant effects. Other recent reviews of omega 3 trials found that omega 3 fats decrease mortality, but the publication of a large contradictory trial has c...

Antioxidant selenium offers no heart-disease protection

...nd previous research based on smaller intervention trials focusing on cardiovascular risk factors," said Stranges. "Our findings are consistent with those from previous studies that have shown no beneficial effect of selenium supplementation in combination with other antioxidants on the primary prevention ...

For one Stanford doctor, the beat goes on during open-heart surgery

...e consensus report, based on randomized controlled trials and retrospective studies, concluded that when complications such as blood loss, stroke, kidney failure and irregular heart beats were considered, beating-heart surgery had a definite advantage over conventional bypass. "Beating-heart surgery is an ...

Chemotherapy gel may fight breast cancer and reduce breast deformity

...ter surgery." According to Dr. Edington, clinical trials on women with breast cancer will follow additional laboratory studies. A paper detailing these results will be published in the Journal of Biomedical Materials Research. ...

Powerful technique for multiplying adult stem cells may aid therapies

... cells back into the patients. While many clinical trials have succeeded, some ended tragically when the virus ended up activating a cancer-causing gene. Because of this, the Food and Drug Administration is not currently approving any gene-therapy clinical trials. "If, before the stem cells have been re-i...

Experimental TB drug effective against resistant and latent mycobacterium tuberculosis

.... If the drug lives up to the promise in human trials that it showed in the laboratory, it could be available for treatment of MDR-TB in two to three years, says Owens. ...

Researchers release new variety of asparagus

...h at least a dozen trials, but we need to keep the trials going for a while longer because it may be affected by weather or diseases that only occur occasionally," Roose said. "It will take several years before significant amounts of this new variety appear in the market." Asparagus, a perennial vegetable,...

Concern over fast tracking of new drugs

...ss of $2bn. Around 3000 patients took part in the trials and nearly 5000 patients have been treated in the ...lso highlights the potential risks for patients in trials of new drugs where knowledge of long term efficacy, outcome measures, and safety is lacking. Short ...

International HIV/AIDS trial finds continuous antiretroviral therapy superior to episodic therapy

.... "SMART is one of the largest HIV/AIDS treatment trials ever conducted," notes NIAID Director Anthony S. Fauci, M.D. "The study reflects an extraordinary global collaboration among hundreds of dedicated AIDS clinicians and thousands of their patients, all of whom should be commended for their exceptional ...

New influenza vaccine takes weeks to mass produce

...ecombinant hemagglutinin (rHA). Phase II clinical trials show that rHA-based vaccines produced using this system are safe, elicit immunity equal to or greater than egg-based vaccines, and are 100% effective in the prevention of cell culture confirmed influenza. Wang and his colleagues report the successf...

Gene therapy 'turns off' mutation linked to Parkinson's disease

...lpha-synuclein gene will be developed for clinical trials for Parkinson's patients. ...

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