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Tag: "trials" at biology news

Cyberkinetics, Case to develop system to help restore extremity function

...investigational device currently in pilot clinical trials that consists of an internal sensor to detect brai...inetics is currently conducting two pilot clinical trials of the BrainGate TM System. In its first pilot clinical trial currently underway, clinical research...

Gene therapy for muscular dystrophy fixes frail muscle cells in animal model, Stanford study finds

...and the skin disease, epidermolysis bullosa. Early trials using her approach have looked promising in animal models of both of these diseases. "I think our approach has a lot of potential to overcome issues that have slowed the field of gene therapy," Calos said. Calos said her approach has two advantages...

Anti-cancer drugs may hold promise for premature aging disorder

...n. FTIs are now being tested in phase III clinical trials of patients with myeloid leukemia. So far, clinical trials using FTIs have found little toxicity, even when the drug treatment significantly raises levels of u...

Magnetic probe successfully tracks implanted cells in cancer patients

...k for and destroy. Since the mid-1990s, clinical trials have been testing dendritic cells to see whether t...ed to the patients. However, some of the clinical trials of such "cancer vaccines" have been disappointing, with some patients responding very well but other...

Polymer gel can block toxic leakage problem in gene therapy

... about 66 percent of the 918 gene therapy clinical trials conducted in 24 countries between 1989 and 2004 we... reports of animal deaths during past gene therapy trials with adenoviruses, this study provided the first direct research evidence that therapeutic gene-bear...

Clinical trial to test stem cell approach for children with brain injury

...similar age who suffered a similar injury. Safety trials involve too few patients to draw broad conclusions about the effectiveness of treatment. But they can set the stage for larger-scale research. "All the preclinical data suggest this is a safe procedure with substantial information suggesting a poss...

Compound from marine bacteria shows potential as multiple myeloma therapy

... The compound will be moved into Phase I clinical trials in early 2006, say officials of Nereus Pharmaceuti...east one prior treatment, demonstrated in clinical trials that it extended the time to disease progression and also improved survival. Though less toxic than...

Sangamo BioSciences demonstrates its ZFP treatment protects cells from HIV infection

...lock HIV binding to CCR5, but in recent months two trials have been halted, one due to reports of liver toxi... stated, "After the recent negative news regarding trials with pharmacologic blockade of CCR5, it is very important that we focus on positive results involvin...

Implantable pumps extend lives of patients too sick for transplant

...s currently participating in a number of different trials testing different device models and pumps designs. ...

Federal grant funds research on novel HIV therapy

...asic science research, animal studies and clinical trials in adult patients, the new grant focuses on a pote...s study aims to provide proof of concept for human trials under Project 4. Project 4, led by Pablo Tebas, M.D., of the Department of Medicine at the Univers...

Recreating 'Flowers for Algernon' with a happy ending

...on approved the use of the drugs in three clinical trials currently under review to test the effect of stati...abilities. We don't have to do extensive clinical trials for toxicity or safety ?these were already completed for other uses." ...

Common alternative treatment for liver disease is found to be ineffective

Results of high-quality randomized clinical trials have determined that milk thistle extract, a widel...ioned types of liver disease were studied in these trials over a period of six months, in groups treated with milk thistle versus placebo treatment. No signi...

Mutations in the BRAF gene predict sensitivity to a novel class of cancer drugs

... new class of drugs -- now in early stage clinical trials -- work best in patients with mutations in the BRA... and Development), is now being tested in clinical trials of patients with melanoma, colon, breast, and lung cancers. In addition, by re-analyzing the data on...

Study shows combination of immune substances to be safe

... the two drugs in people with melanoma. Phase-II trials are the first step in determining the effectiveness of new therapy against a specific disease. "We believe that use of the two drugs together will give us more bang for the buck," says first author Gregory B. Lesinski, a research assistant professo...

Mouse study: New muscle-building agent beats all previous ones

...ice. An antibody against myostatin now in clinical trials caused mice to develop muscles 25 percent larger than those of untreated mice after five weeks or more of treatment. The researchers' expectation is that blocking myostatin might help maintain critical muscle strength in people whose muscles are wa...

Sensors, a smart dose of medicine for cancer treatment

... is working and we'll have the results of patients trials in the next few months," says Jaksic. "We need to further optimise some parameters of the diode sensor system, but from the work we've done so far we know how to solve these remaining issues." Jaksic believes it is worth the wait. "Unlike most proje...

Stem cell mobilization therapy appears to be ineffective in repairing damage caused by heart attack

...l had a cohort that was larger than all 3 previous trials taken together and had a relatively long follow-up period based on sensitive assessment methods of left ventricular function and infarct size. In conclusion, use of G-CSF therapy to mobilize bone marrow–derived stem cell does not improve left ventric...

Duke to test bird flu vaccine dosing

..., Europe and Africa and killed 101 humans. Initial trials in healthy adults showed the vaccine was safe and produced an immune response but required high doses and at least two injections to initiate a strong response, Walter said. Trial participants will receive varying strengths of the H5N1 vaccine, eith...

Newly identified mechanism helps explain why people of African descent are more vulnerable to TB

...osis. The researchers suggest a need for clinical trials to investigate the effect of vitamin D supplementation. "Our results indicate that we have much yet to learn about human immune responses to infections. They also emphasize the importance of vitamin D in human immune responses, and suggest that it ...

New Rotavirus vaccine joins routine infant immunization schedule

...0,000 children annually. Merck conducted clinical trials of RotaTeq in more than 70,000 infants in 11 countries--one of the largest clinical trials to be performed by a pharmaceutical company. The company's data showed that the vaccine prevented 98...

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