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Tag: "trials" at biology news

Why were the HIV prevention trials in commercial sex workers abandoned?

...ed the progress of at least two important clinical trials of tenofovir as PREP and brought negative attentio...sguided ethical imperialism that derailed the PREP trials do not live in Paris, but as usual in Nairobi, Johannesburg, Phnom Penh, and Calcutta." ### Citati...

Scientists show that tick-borne flaviviruses use a novel mechanism to evade host defenses

...ese infections that it is being tested in clinical trials to treat infection with various flaviviruses. But the treatment appears to fail in about half of cases. Dengue virus, West Nile virus and yellow fever virus have a protein called NS4B that prevents interferon from functioning properly. It was though...

Secrets to antibody's success against West Nile Virus surprise scientists

... West Nile and related viruses undergoing clinical trials stimulate production of antibodies that stop infections at a similar point. In 2004, West Nile virus, which is a mosquito-borne flavivirus, reportedly caused 2,470 infections and 88 deaths in the United States. First isolated in Africa in 1937, We...

Lance Armstrong through a physiological lens: hard training boosts muscle power 8%

...t all subjects performed extensive familiarization trials before testing and that a control group showed no change in endurance performance when tested 2 weeks apart with no sprint training intervention." In addition, though previous studies showed increases in citrate synthase (CS) activity and glycogen co...

Mass production of human papillomavirus could lead to gains against cervical cancer

...ve attenuated virus. "Current vaccines in clinical trials consist of capsid proteins and trigger an immune response to those proteins," he said. "However, in its earliest stage, papillomavirus does not express those proteins, making the virus invisible to that immune response. "A sufficiently non-virulent,...

HIV Therapy Greatly Extends Life of Key T Cells, Scientists Find

...up, says Dr. Kovacs. Two large, long-term efficacy trials currently underway should provide a clearer pictur... adds. Information on these and other HIV clinical trials is available at www.aidsinfo.nih.gov. Other authors on the paper include researchers from the NIH’s...

Discovery of T-cell 'traffic control' boosts new drug promise

...tzl nor Rosen is involved in the on-going clinical trials of the new drugs and neither has financial ties to...rol heart rate and muscle development. In clinical trials of some of these kinds of drugs, a number of patients have tired easily, experienced lower blood flo...

AIDS expert says global strategy needed to combat feminization of HIV/AIDS

...inn and his team are renowned for leading clinical trials of the first effective treatments that prevent HIV from replicating, and helping to establish laboratory and treatment facilities in the Democratic Republic of the Congo, India and Uganda, and counselling other governments across Africa and Asia abou...

Molecular miners find pain relief drugs from the sea

...cently announced successful results in preclinical trials of the toxin. The company will begin clinical trials in humans this month to firstly test the safety of the toxin in normal males, and later its effectiv...

A vaccine to kill tapeworm

...r countries killed by a gruesome parasite. Initial trials suggest it is nearly 100 per cent effective. The ...ors in Lima, Peru, now have plans for larger field trials in which the pigs will be allowed to forage as normal, they reported at a conference on parasitology...

UF researchers kill resistant bugs one bandage at a time

...teria from getting back into the wound." Clinical trials of the coating in gauze will be conducted at UF later this year. Controlling moisture and staving off infection are two of the most important aspects of wound healing, said Jeffrey M. Davidson, Ph.D., president of the Wound Healing Society and a Van...

Women cautioned against using herbal supplements

...oints to not only a lack of well-designed clinical trials but also to a lack of any regulations regarding ef... menopause, Warren reports that the seven clinical trials using black cohosh were largely flawed but might suggest some effectiveness. However, little evidenc...

Can two killers make a cure?

...rth Carolina, Chapel Hill. "This could be in human trials pretty soon." Kobinger now plans a more extensive...nce the US Food and Drug Administration that human trials will be safe. The hybrid virus is created by adding HIV RNA, a stripped-down version of the Ebola su...

Menopause Symptoms May Come Back After Stopping Menopausal Hormone Therapy

...oints to not only a lack of well-designed clinical trials but also to a lack of any regulations regarding ef... menopause, Warren reports that the seven clinical trials using black cohosh were largely flawed but might suggest some effectiveness. However, little evidenc...

Clear rules needed to govern deep sea bioprospecting: UNU

...ge-derived steroid compound completed phase one US trials as an asthma drug in 2000. Other research in progress includes treatments for breast and ovarian cancer. Impediments to this research include not just the high expedition costs but the absence of clear rules governing resource access benefits sharin...

A Father’s Day Gift: Free DNA Paternity Testing

...ge-derived steroid compound completed phase one US trials as an asthma drug in 2000. Other research in progress includes treatments for breast and ovarian cancer. Impediments to this research include not just the high expedition costs but the absence of clear rules governing resource access benefits sharin...

Opiates Better Than Sedatives For Treating Newborns In Withdrawal

...g both the content and quality of existing medical trials on a topic. The reviews included 13 studies with a total of 890 infants of mothers who had used opiates with or without other drugs (including antidepressants, sleep aids and marijuana) during pregnancy. Researchers say two of the studies may have i...

Researchers discover new route to hemoglobin synthesis

...g both the content and quality of existing medical trials on a topic. The reviews included 13 studies with a total of 890 infants of mothers who had used opiates with or without other drugs (including antidepressants, sleep aids and marijuana) during pregnancy. Researchers say two of the studies may have i...

Visceral Leishmaniasis: Successful Vaccine Trial In Dogs

...n proteins excreted by the parasite (1). The first trials indicate that this would completely and lastingly protect dogs against the disease. Twelve out of 18 dogs included in the study were treated with increasing doses of protein antigens excreted by the parasite (that is 50, 100, 200 micrograms) made up...

Columbia scientists develop cancer terminator viruses

...closer to this objective and the start of clinical trials with these viral-based therapies in cancer patient...ic to cancer cells and is now in phase II clinical trials as a cancer gene therapeutic. "We are extremely excited about these results and the prospect of on...

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