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Tag: "trials" at biology news

Columbia research lifts major hurdle to gene therapy for cancer

...iruses based on the PEG switch for use in clinical trials withpatients. Other investigators associated with the PNAS study includeDrs. Zao-zhong Su (research scientist), Devanand Sarkar (associateresearch scientist) and Luni Emdad (postdoctoral research scientist) inDr. Fisher's group; Drs. Gregory J. Duigo...

Recent breakthroughs in common adult leukemia highlighted in New England Journal of Medicine

...ically available to doctors, and after large-scale trials testing early intervention are completed, the 'watchful waiting' practice may be abandoned in many cases," said Dr. Rai, who treats many CLL patients. "New and upcoming discoveries made collectively by us and many other scientists around the world ma...

U-M scientist to talk about tissue engineering at AAAS

... in humans, but Krebsbach said some small clinical trials are under consideration. If the combination therapy approach works, Krebsbach said the next step would be working with engineers to develop anatomically correct scaffolding with the same curvature and contours of natural bones. That would help a pat...

Live Recombinant Adenovirus Vaccine Technique Explored

...de. Recombinant HPV vaccines currently in clinical trials may not be ideal in poorer countries because they are expensive and require multiple immunizations. The Hopkins researchers developed their vaccine prototype using canine oral papillomavirus (COPV), which behaves similarly to HPV. Research by other ...

Leukemia Drug Breakthrough Study In New England Journal Of Medicine

...ata from two recent confirmatory phase II clinical trials performed nationwide involving more than 350 patients with red blood cell transfusion-dependent MDS - to the U.S. Food and Drug Administration in a new drug application (NDA) for Revlimid as an innovative approach to treat the anemia of MDS patients ...

Gene therapy converts dead bone graft to new, living tissue

...arz's research. Schwarz hopes to begin early human trials with the procedure soon. "This technology looks like it will have a dramatic effect on success rates for cancer patients who would otherwise be facing choices as drastic as amputation," says Arthur A. Gertzman, executive vice president for research ...

Muscle-targeted gene therapy reverses rare muscular dystrophy in mice

...se with the disease is infused weekly. In clinical trials of the replacement therapy, the infusions have alr...therapy in Pompe disease," Koeberl said. Clinical trials of either the muscle- or liver-targeted gene therapies will likely take several years to launch, Koe...

Gene Therapy For Parkinson's Disease Moves Forward In Animals

...nson's disease. But its use has been debated since trials in humans ended last year without showing clinical...rld's largest biotechnology company, conducted the trials and later halted use of the drug because of safety concerns, creating an outcry from hopeful Parkins...

Gene vaccine for Alzheimer's disease shows promising results

...ia.From the mouse studies and in previous clinical trials of patients withAlzheimer's disease, immunization ...ed to slow cognitive loss."Although human clinical trials are still at least two years out,theoretically, we are on the right track," he said....

Scientists identify molecular events that drive cell senescence

...ia.From the mouse studies and in previous clinical trials of patients withAlzheimer's disease, immunization ...ed to slow cognitive loss."Although human clinical trials are still at least two years out,theoretically, we are on the right track," he said....

Bird Brains Show How Trial and Error May Contribute to Learning

...ecording equipment can detect them. The systematic trials were possible with the aid of a computer program that could track the bird twitters and trigger stimulations to LMAN at precise moments to elicit measurable effects on a predetermined syllable, song after song. The researchers found that different a...

Gene therapy for Parkinson's disease moves forward in animals

...nson's disease. But its use has been debated since trials in humans ended last year without showing clinical...rld's largest biotechnology company, conducted the trials and later halted use of the drug because of safety concerns, creating an outcry from hopeful Parkins...

Implanted Devices Detect High-Risk Heart Failure Patients

...of the new data which they can provide. Additional trials will be needed to tease out the relationships between different patient characteristics, the use of the new technology, and patient outcomes, Gilliam said. The CRT-D devices were developed by Guidant Corp., Indianapolis, which funds the Heart Failur...

PCRM develops world's first cruelty-free insulin assay

..., was developed as part of PCRM's ongoing clinical trials to test the effects of a low-fat, vegan diet on patients with type 2 diabetes. "We only had two options available to us when we began our diabetes trials," said Dr. Barnard. "One, we could use test kits with insulin antibodies grown in vivo--literal...

Antibiotic might fight HIV-induced neurological problems

...d more. The drug is being tested in early clinical trials for some non-HIV-related conditions. "Last year we discovered that SIV triggers some of the same biological pathways of cell death and inflammation as these other diseases," says Sheila Barber, Ph.D., assistant professor of comparative medicine. "Te...

Genetically modified rice in China benefits farmers' health, study finds

Farmers growing genetically modified rice in field trials in China report higher crop yields, reduced pestic...f data from eight rice pre-commercialization field trials in China. Their goal was to determine whether genetically modified rice was helping farmers reduce p...

UCLA launches $20 million stem cell institute to investigate HIV, cancer and neurological disorders

...son Cancer Center features an established clinical trials infrastructure that could be used to test new therapeutics that may develop as a result of the stem cell studies, said Judith C. Gasson, cancer center director, stem cell institute co-director, and a professor of medicine and biological chemistry. "...

NASA links nanobacteria to kidney stones and other diseases

...ts. To further comprehend the implications of NB, trials were conducted at NASA to examine NB, in a bioreactor chamber which simulates conditions of space travel. In this microgravity environment, NB was found to multiply five times faster compared to normal gravity on Earth, supporting earlier discoveries...

New Drugs For Bad Bugs: UF Approach Could Bolster Antibiotic Arsenal

...roach aims to ensure that doses tested in clinical trials are adequate and likely to yield good results, said Dr. William Craig, a professor of medicine at the University of Wisconsin, adding that until now, “many, many antibiotics that initially came out have either had their dosages changed because they w...

Gene therapy promising for growing tooth-supporting bone

...e said he optimistically would like to see initial trials begin in humans in four to seven years. BMP-7 is part of a family of proteins that regulates cartilage and bone formation. Recent studies have shown that BMPs are present in tooth development and periodontal repair. This study mixed BMP-7 genes wit...

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