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Tag: "trial" at biology news

Scientists use gene transfer technology and common virus to block neuropathic pain

...cientists plan to conduct the first phase I safety trial of a related HSV vector in patients with pain caused by terminal cancer, which has spread to bone. ...

Breast tumors in mice eradicated using cancer vaccine

... vector is currently being prepared for a clinical trial targeting a tumor antigen associated with cervical cancer by Advaxis Inc., a cancer vaccine biotech company that has licensed Penn patents on the use of Listeria monocytogenes as a vaccine vector. Paterson is the scientific founder of Advaxis and Cha...

Vaccine targets tumors where they live

...cal setting. The data represent the first clinical trial to directly inject a vaccinia virus expressing the B7.1 costimulatory molecule into humans with melanoma. The researchers show that this vaccine is safe and feasible to use for local delivery into established melanoma lesions. 2 of the injected lesi...

Researchers develop gene therapy to reverse pulmonary arterial hypertension

...ndrial diseases, the team is initiating a clinical trial in human PAH. Similarly, newer drugs that inhibit Survivin, currently in trials in oncology, might also be directly applicable to PAH patients, Dr. Michelakis explains. The researchers are supported by the Canadian Institutes of Health Research and ...

Scientists use gene transfer technology and common virus to block neuropathic pain in animals

...cientists plan to conduct the first phase I safety trial of a related HSV vector in patients with pain caused by terminal cancer, which has spread to bone. The research was supported by grants from the National Institute of Neurological Disorders and Stroke and the Department of Veterans Affairs. Addition...

Results of world's first gene therapy trial for arthritis show approach safe, feasible

...huttles a gene into cells ?as a more recent French trial for X-linked severe combined immunodeficiency (X-S... antagonist, or IL-1 Ra. Because it was the first trial of its kind and safety was a key concern, the protocol was designed so that the gene would be delive...

Hanging baskets of sex and death help fruit growers

...East Malling Research on a larger scale 12 hectare trial of the dispenser in a large commercial apple orchard in Worcestershire. An array of 25 dispensers per hectare have been erected over 3 separated orchard plots of one hectare within an even larger orchard. The codling moth control within these three...

Visceral Leishmaniasis: Successful Vaccine Trial In Dogs

...ghly encouraging, data from a large-scale clinical trial currently under way (phase III), are promising for efforts to reduce transmission of leishmaniasis to humans. They also point to new lines of investigation for elaborating a possible human vaccine. An integrated research project, involving several IR...

Can two killers make a cure?

...s in the US could soon be asked to approve a human trial of gene therapy for cystic fibrosis that uses a hy...soon." Kobinger now plans a more extensive monkey trial to convince the US Food and Drug Administration that human trials will be safe. The hybrid virus is ...

Old drug, new tricks: Prospects for slashing the impact of malaria

...act of malaria is in prospect with a clinical drug trial to begin in Papua New Guinea early next year. Success in the trial would open the way to relief in the 10% of humanity infected with this debilitating and often fatal ...

New imaging technology shown to detect pancreatic inflammation in type 1 diabetes

...mily history and antibody testing. At present, the trial is enrolling only at-risk individuals who have alr...ividuals interested in more information about this trial should contact Jason Gaglia at Joslin Diabetes Center at 617-732-2481 or jason.gaglia@joslin.harvar...

Organic farms produce same yields as conventional farms

...r and no pesticides, a review of a 22-year farming trial study concludes. David Pimentel, a Cornell University professor of ecology and agriculture, concludes, "Organic farming offers real advantages for such crops as corn and soybeans." Pimentel is the lead author of a study that is published in the July...

Discovery of T-cell 'traffic control' boosts new drug promise

...nk this mechanism underlies the promising clinical trial results of a new drug against multiple sclerosis (MS) recently reported by other researchers. That study showed that the experimental drug, FTY720, significantly reduced the destructive autoimmune process in patients with MS, a debilitating disease i...

Neurologix announces positive results of gene therapy clinical trial in Parkinson's disease

...e and Other Movement DisordersNeurologix's Phase I trial showed positive interim results in patients with P...erim results of its landmark gene therapy clinical trial for patients with Parkinson's disease. Neurologix's 12-patient, dose-escalating Phase I trial is th...

A slight difference and significant similarities

... all, almost 2,800 potato specimens, cultivated in trial fields at the German Federal Agency for Agriculture and Food, were tested. A team of biologists, chemists and computer scientists from Potsdam and Aberystwyth in Wales took part in the evaluation. ...

Chemical 'band-aid' prevents heart failure in mice with muscular dystrophy

...d for 24 hours to 72 hours in a phase III clinical trial for patients with sickle-cell anemia, but questions about the safety of long-term use remain. "If issues of dosing and long-term safety can be resolved, our research suggests that poloxamer 188 could be a new therapeutic agent for preventing or limi...

Lance Armstrong through a physiological lens: hard training boosts muscle power 8%

...trong's "freely chosen cycling cadence during time trial races of 30- to 60-minute duration increased progressively during this y-year period from about 85-95 rpm to about 105-110 rpm. This increase in freely chosen rpm when cycling at high intensity is indeed consistent with increase in type I muscle fibe...

Compound from Chinese medicine shows promise in head and neck cancer

...lthy tissue. Researchers hope to begin a clinical trial in head and neck cancer patients within a year, testing whether (-)-gossypol can be used along with chemotherapy to create a better response and avoid surgery. More than 29,000 people will be diagnosed in 2005 with head and neck cancers, which inclu...

Why were the HIV prevention trials in commercial sex workers abandoned?

...ence in Bangkok, Thailand last year against a PREP trial of tenofovir among Cambodian commercial sex workers caught the world's media attention. But Jerome Singh, of the Centre for the AIDS Programme of Research in South Africa, University of KwaZulu–Natal, and Edward Mills of the Department of Clinical Ep...

New type of rejection blocker protects kidneys after transplant

... UCSF Medical Center. "This is the first clinical trial of a treatment for transplant recipients based on ...led the first patient to receive belatacept in the trial early in 2001. Twenty UCSF patients have been taking the drug for more than three years. "So far, re...

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