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Tag: "trial" at biology news

Researchers reverse juvenile diabetes in animal model

...inistration (FDA) approved the start of a clinical trial to evaluate the safety and feasibility of the treatment (Phase 1 trial). The trial is expected to begin sometime this spring and will include at least 15 patients over the age of 18, ...

Low-cost drug gaining favor for use in HIV-infected children in poor countries

...inical trial. Grimwade's search turned up only one trial that passed that litmus test: a study of 534 HIV-p... said. Every medication has side effects, and the trial did uncover some adverse reactions from cotrimoxazole. Still, Grimwade said the Zambian study shows ...

Mouse study reveals human X-SCID gene therapy poses substantial cancer risk

...ld explain why one of three children in the French trial developed T-cell leukemia. Two developed the disea...hird cancer case had not been solved. The French trial is the largest to date to test IL2RG gene therapy, and of the 10 children treated, nine were success...

Intelligently designed molecular evolution

...olution of promiscuous enzymes is achieved through trial and error, similar to the way in which the human immune system works. Multiple combinations of many different amino acid substitutions are tested in promiscuous enzymes until an evolutionary path that achieves a desired result is found. The amino a...

H5N1 avian flu virus vaccine induces immune responses in healthy adults

Results from a clinical trial demonstrate that high doses of an experimental H5N...of the highest dosage of the vaccine tested in the trial developed levels of infection-fighting antibodies that current tests predict would neutralize the vi...

New male contraceptive clears hurdle

...n eagerly awaiting the results of a large clinical trial in India. The trial is studying a new male contraceptive, RISUG (Reversible Inhibition of Sperm Under Guidance): a rever...

Duke to test bird flu vaccine dosing

A clinical trial to test different strengths of a vaccine designed ...l Center. The Duke study is part of a multicenter trial that will test a modified form of an investigational bird flu vaccine to determine whether the vacci...

Free HIV tests cheaper than charging when goal is preventing AIDS

... with a modest advertising campaign. Once the free trial began, KIWAKKUKI's AIDS Information Center was deluged with clients. "Our colleagues at KIWAKKUKI called it the 'crash' period because it was kind of crazy," Thielman said, with nearly four times as many people coming in on some days for the free HIV...

DNA gene vaccine protects against harmful protein of Alzheimer's disease

... the cancellation of a previous multi-center human trial with amyloid-beta 42, researchers said. UT Southwe...l studies, with the ultimate goal being a clinical trial in humans. The researchers also plan to see if it can reverse the size of established plaques in the...

Stem cell mobilization therapy appears to be ineffective in repairing damage caused by heart attack

...CSF treatment," the authors write. "The REVIVAL-2 trial had a cohort that was larger than all 3 previous trials taken together and had a relatively long follow-up period based on sensitive assessment methods of left ventricular function and infarct size. In conclusion, use of G-CSF therapy to mobilize bon...

Human trial proves ricin vaccine safe, induces neutralizing antibodies; further tests planned

Scientists have completed the first human clinical trial of a recombinant vaccine for the deadly toxin rici...and the mice survived. The results of the vaccine trial will be available this week online and in an upcoming issue of the Proceedings of the National Acade...

Eisai announces Phase II data on E7389, a potential new therapy for the treatment of breast cancer

...actory breast cancer. The primary endpoint of this trial was response rate, measured using the RECIST (Response Evaluation Criteria In Solid Tumors) criteria ?a group of standards used to measure responses to treatment in solid tumors. Of the 65 evaluable patients, 10 partial responses were confirmed at t...

Study shows combination of immune substances to be safe

...ues are conducting a multicenter phase II clinical trial of the two drugs in people with melanoma. Phase-II trials are the first step in determining the effectiveness of new therapy against a specific disease. "We believe that use of the two drugs together will give us more bang for the buck," says fir...

New malaria vaccine shows promise in early clinical trial

...t Pasteur in Paris) have completed the first human trial of a vaccine based on MSP3, a protein present on t...rward way to test this is to expose the vaccinated trial participants to malaria and see if they are protected. However, this risky test is not ethical durin...

Feds give researchers ok for safety test of adult stem cells in patients with heart disease

...stitute (HCRI) has been contracted to help run the trial and will establish an independent data and safety ...ents with this heart condition," said Adler. The trial is one of three ongoing studies in the United States to use bone marrow stem cells to treat chronic ...

Gene variation affects tamoxifen's benefit for breast cancer

...y research group conducting a prospective clinical trial to confirm whether genetic testing can be used to ... estrogen in breast tissue. The findings from this trial were derived from a large North Central Cancer Treatment Group study in which women were treated wit...

'Creationism is not science' ?making the case for Darwin at UCL

...Pennsylvania will take their local school board to trial over the introduction of Intelligent Design into the school's curriculum. The outcome of that will surely go down in the history books." ...

Federal grant funds research on novel HIV therapy

...ylvania Medical School, will be a phase 1 (safety) trial of the NK-1R antagonist aprepitant (trade name Emend) in adults with HIV infection. Aprepitant is currently used to control nausea caused by chemotherapy; this project will determine whether the antagonist may also attack HIV infection in patients. ...

Implantable pumps extend lives of patients too sick for transplant

...plantation, according to the results of a clinical trial led by Duke University Medical Center cardiologist...eph Rogers, M.D., who presented the results of the trial Nov. 14, 2005, at the annual scientific session of the American Heart Association meeting in Dallas....

Sangamo BioSciences demonstrates its ZFP treatment protects cells from HIV infection

...nia with the goal of initiating a Phase 1 clinical trial to test our ZFP Therapeutic in 2006." Dr. Carl June, Director of Translational Research at the Abramson Family Cancer Research Institute at the University of Pennsylvania School of Medicine, is a leader in the field of research testing T-cell therap...

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