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Tag: "trial" at biology news

Anti-inflammatory drug's potentially deadly side effect found to be rare

...e fatal and one nonfatal case of PML occurred in a trial using natalizumab as a multiple sclerosis treatment; a second fatality happened in a trial that used the drug to treat patients with Crohn's disease, an inflammatory bowel disorder. "Our ana...

AIDS-related cognitive impairment exists in two separate forms

... the test will soon be validated in a multi-center trial for submission to the FDA. She also added that while this study analyzed prostatectomy samples, Epigenomics is expanding its research to see if the same results can be obtained from prostate biopsies. "If the test is a strong enough predictor of a go...

Markers of gene, protein, or micro-RNA activity predict outcome in prostate and colorectal cancers

... the test will soon be validated in a multi-center trial for submission to the FDA. She also added that while this study analyzed prostatectomy samples, Epigenomics is expanding its research to see if the same results can be obtained from prostate biopsies. "If the test is a strong enough predictor of a go...

An elephant tail

...Age in Myocardial Infarction (VINTAGE MI) clinical trial to test whether administering L-arginine to patien... The randomized, double-blind, placebo-controlled trial included 153 STEMI patients; 77 were 60 years or older. Participants were enrolled from February 20...

Little known DNA repair enzyme may be a tumor suppressor gene

...Age in Myocardial Infarction (VINTAGE MI) clinical trial to test whether administering L-arginine to patien... The randomized, double-blind, placebo-controlled trial included 153 STEMI patients; 77 were 60 years or older. Participants were enrolled from February 20...

Use of amino acid supplement following a heart attack provides no benefit, may be harmful

...Age in Myocardial Infarction (VINTAGE MI) clinical trial to test whether administering L-arginine to patien... The randomized, double-blind, placebo-controlled trial included 153 STEMI patients; 77 were 60 years or older. Participants were enrolled from February 20...

All placebos not created alike

...to test the effectiveness of a new treatment, this trial pitted one placebo against another. "It's upside d...bo pill vs. real pain pill trial. The acupuncture trial extended four more weeks (the length believed needed to see improvement), and the pill trial lasted ...

New vaccine for condition that kills 500,000 children a year

...f a new rotavirus vaccine was to launch a clinical trial involving more than 60,000 infants. In 2000, Merc...e as the U.S. principal investigator in a clinical trial of RotaTeq, a vaccine under development. RotaTeq targets five major strains of rotavirus, which ac...

New licensing agreement to maximize AIDS drug development

...ls. They are currently managing a second Phase III trial of a microbicide called Ushercell in Uganda and South Africa, Benin, Burkina Faso and two centers in India. The trials will evaluate Ushercell for the prevention of HIV infection among 2,574 adult women at high risk of acquiring HIV. This study wil...

Can dogs smell cancer?

...by sniffing the breath of cancer participants. The trial itself was comprised of 86 cancer patients (55 with lung cancer and 31 with breast cancer) and a control sample of 83 healthy patients. All cancer patients had recently been diagnosed with cancer through biopsy-confirmed conventional methods such as ...

Cyclosporine inhibits hepatitis C virus in vitro

...uthors write. A prospective randomized comparative trial between cyclosporine and TAC should further evaluate their observations. "Due to the accelerated rate of disease progression and graft failure after liver transplantation in HCV patients," the authors conclude, "it will be very important to determin...

Intensive statin therapy may partially reverse plaque build-up in arteries

...ed Coronary Atheroma Burden [ASTEROID] Trial). The trial was conducted at 53 community and tertiary care centers in the United States, Canada, Europe, and Australia. A total of 507 patients had baseline intravascular ultrasound (IVUS) examination and received 40 mg daily of rosuvastatin (brand name Cresto...

Anti-HIV drug has potential to prevent transmission in women

...e tenofovir gel's Phase I safety and acceptability trial has already led to a larger Phase II safety study in at-risk women due to begin in the spring of 2006. According to the study, there was a high acceptability rate among participants, as 94 percent of women said they would definitely or probably use...

International HIV/AIDS trial finds continuous antiretroviral therapy superior to episodic therapy

...hat enrollment into a large international HIV/AIDS trial comparing continuous antiretroviral therapy with e...re details see http://www.smart-trial.org ). The trial involved an international collaboration of 318 clinical sites in 33 countries. It began enrollment i...

Concern over fast tracking of new drugs

...is, and its recall three months later, after three trial patients developed a life threatening condition wh...shed trials. The FDA granted approval before final trial and cumulative safety data were available. Natalizumab was predicted to be the leading drug for mult...

Researchers release new variety of asparagus

...are working on other promising hybrids that are in trial at the moment, some of which may have even better yields than DePaoli." Currently, UCR is cultivating the DePaoli variety in a field near campus. The first test of the new variety, which involves evaluation of yield, spear quality, and other trait...

Antioxidant selenium offers no heart-disease protection

...alysis of a randomized placebo-controlled clinical trial covering 13 years has shown. The selenium-CVD asso...s of the trial, the only large randomized clinical trial to date to examine selenium supplementation alone in the prevention of CVD, appear in the April 15 i...

Evidence for omega 3 fats less conclusive than we thought, say experts

...lity, but the publication of a large contradictory trial has changed the overall picture. The authors cannot say exactly why the results of this trial differ from the other large studies in this field. They therefore conclude that it is not clear whe...

Ebola DNA vaccine produces immune responses in all fully vaccinated volunteers in Phase 1 trial

...controlled, dose-escalation study, the first human trial for any Ebola vaccine, was sponsored by the Nation...g in Washington, D.C., by Julie E. Martin, D.O., a trial investigator and research scientist at NIAID's Dale and Betty Bumpers Vaccine Research Center (VRC),...

BiovaxID?yields 89 percent survival in patients with aggressive non-Hodgkins

...ceuticals, Inc. report follow-up data to a Phase 2 trial conducted by the National Cancer Institute (NCI) t...est is now enrolling patients in a pivotal Phase 3 trial to test BiovaxID against follicular non-Hodgkin's lymphoma (NHL). Follicular NHL is an indolent (slo...

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