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Tag: "trial" at biology news

'Molecular assassin' targets disease gene

...th the drug over an eight-week period. "If such a trial were successful, it would be a significant development given the high rates of skin cancer and because the main treatment currently is surgical excision, which can cause scarring," said Professor Khachigian. "Conventional anti-inflammatory drugs ar...

Trials for new drug to overcome HIV

...e resistant to other anti-HIV drugs. A small human trial of the drug, reported last August, showed that whe...down the levels tenfold in a matter of hours. The trial planned for this month is intended to discover how the drug performs as part of a combination treatm...

Scientists tie several cancers to common 'oncogene engine'

...nts with advanced melanoma. "We have just opened a trial to offer the same vaccine to patients with all of the other cancers in this related family," said Fisher. "Prior to this, virtually no rational experimental treatments were available for these diseases, and patients have already started coming from t...

Hopkins scientists show hallucinogen in mushrooms creates universal 'mystical' experience

... where the work could lead, the team is planning a trial of patients suffering from advanced cancer-related depression or anxiety, following up suggestive research several decades ago. They're also designing studies to test a role for psilocybin in treating drug dependence. ...

New bird flu drug promises to beat the problem of resistance

...given the long period of time it takes to properly trial and evaluate a new anti-viral drug, it could be up to fifteen years before we see the resulting treatment on the shelves." Whilst Dr Watts will be making the molecules at the University of Bath, the initial trials on the influenza virus will be car...

Gene therapy injected into the brains' of mice with Huntington's disease

...PD). The company completed enrollment of a Phase I trial with CERE-120 at UCSF and Rush University Medical ... spring. Initial efficacy results of this Phase I trial are expected to be presented this fall and a double-blinded, controlled Phase II trail in PD patient...

Brain-computer link lets paralyzed patients convert thoughts into actions

...esults from the initial participants in a clinical trial of the BrainGate Neural Interface System, a "neuro...onths, Nagle remained an active participant in the trial and continued to aid the clinical team in producing valuable feedback concerning the BrainGate techn...

Pak1 expression increases tamoxifen resistance in breast cancer patients

...east cancer. The women participated in a clinical trial where they were randomly assigned to receive tamoxifen therapy or no treatment. The authors examined whether tumor levels of Pak1 were associated with the women's chances of breast cancer recurrence and the effects of tamoxifen therapy. The authors...

Tumor wizardry wards off attacks from the immune system

...Medicine, Linehan is planning to set up a clinical trial that pairs T-reg depletion with anti-cancer vaccine as a therapy for pancreatic cancer patients. "We're attacking the problem from different angles hoping to translate these findings to our patients," Linehan says. "Right now, no effective treatmen...

First-ever genomic test predicts which lung cancer patients need chemotherapy to live

...o they can be treated accordingly." The upcoming trial is the first to use a genomic test to select treatment options for individual lung cancer patients, said David Harpole, M.D., a professor of thoracic surgery at Duke and principal investigator of the upcoming clinical trial. The trial, to begin withi...

T cells activated to fight HIV basis for dendritic cell therapeutic vaccine

...l be incorporated into the protocol for a clinical trial of the vaccine, which is expected to begin later t...persons with HIV infection," said Dr. Huang. The trial should be enrolling patients within the year, pending approval by the U.S. Food and Drug Administrat...

Novel therapy combinations gain ground in treating hepatitis

...oup. For the 162 patients who have completed the trial period at 24 weeks, results show that the two higher-dose combination arms had much better response rates than the control group, experiencing on average a 2.5 to 3.0 log decrease in hepatitis RNA reductions by week 24, a significantly better respons...

MIT 'seeing machine' offers hope to blind

...esigned to be used by one eye. The pilot clinical trial of the seeing machine involved visually impaired p...gues are now working toward a large-scale clinical trial of a color seeing machine (the device tested in the pilot trial was black and white). With the color...

New genetic test for breast cancer

...e Medical Center are leading a nationwide clinical trial to determine whether a new genetic test can be use... uncertainty." Women participating in the TAILORx trial will be assigned to one of three groups depending on their recurrence score. If the score is more t...

Viagra improves high altitude exercise performance up to 45% for some

...ot at all. The responders improved 39% in the time trial performance at altitude compared to their performa... participants nor the researchers knew whether the trial included a placebo or one of the two sildenafil doses, 50 mg or 100 mg. The high altitude simulatio...

For Stanford scientists, RNAi gene therapy takes two steps forward, one step back

...effect of another type of RNAi gene therapy not on trial - mice in that study suffered liver toxicity from the treatment and some died. Despite that initial result, to be published in the May 25 issue of Nature, Kay and Grimm went on to find a way that shows promise in resolving this side effect. "Just li...

Radioactive scorpion venom for fighting cancer

...ble to the radiation. The second-sequence phase II trial at Henry Ford involves 3 patients, with a total of 54 patients across the US currently in investigational trials for the therapy. ...

UF scientists test improved gene therapy method for hereditary heart conditions

... said, adding that UF researchers hope to launch a trial in patients with Pompe disease early next year. "Many of the inborn errors have their most feared effects early in life, so we're pushing toward being able to do prevent disease as opposed to trying to correct later. We keep trying to get closer and ...

First human trial of antibacterial contact lens

...eived ethics approval for the first human clinical trial of an antibacterial extended-wear contact lens. ...re for Marine Biofouling and Bioinnovation. The trial beginning on June 29 will compare the safety performance of an antibacterial contact lens to that of...

Tramiprosate (Alzhemed? preclinical results published in Neurobiology of Aging

...and parallel-designed, 18-month Phase III clinical trial in 1,052 mild-to-moderate AD patients which is bei...dy completed 12 months on study medication and the trial is scheduled to be completed by January 2007. All patients who complete the North American Phase III...

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