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Tag: "trial" at biology news

Circumcision: A proven strategy to prevent HIV

...f The Lancet. Researchers conducted a clinical trial enrolling 2,784 HIV negative, uncircumcised men be... assessments throughout the study. The clinical trial found that 47 of the 1,391 uncircumcised men contracted HIV, compared to 22 of the 1,393 circumcised...

Protein therapy may reduce infarct size in heart attack patients

...ety and cardiac outcomes through six months. This trial was designed as an exploratory study to assess the potential impact of KAI-9803 in this “first-in-human?study. Results indicate that KAI-9803 may be associated with less myocardial necrosis with lower CK-MB AUC values at all dose levels. Furthermo...

Light-based probe 'sees' early cancers in first tests on human tissue

... said. His team plans to begin a small clinical trial of the advanced endoscope in collaboration with researchers at Duke University Medical Center. The team also is conducting animal studies to test the feasibility of incorporating fa/LCI into instruments for examining the colon, lung and other organs....

Drug treatment improves learning in mice with Down syndrome symptoms, Stanford/Packard study shows

...ed. The researchers are now considering a clinical trial to test whether the compound has a similar effect in humans with Down syndrome. "This treatment has remarkable potential," said Craig Garner, PhD, professor of psychiatry and behavioral sciences and co-director of Stanford’s Down Syndrome Research C...

Groundbreaking Canadian asthma study

...e very encouraging and are consistent with earlier trial results on bronchial thermoplasty," explains Dr. C...derate or severe asthma. The randomized controlled trial included 112 patients between the ages of 18-65 at 11 centers in four countries, and followed these ...

Clues to gene expression in cystic fibrosis will guide research

...dy authors suggest. Results from a French clinical trial published today in BMC Medicine show how a small percentage of CF sufferers with a rare genetic stop mutation responded positively to gentamicin treatment. Aleksander Edelman and Isabelle Sermet-Gaudelus of Faculté de Médicine Necker in Paris led co...

Investment level in HIV prevention programs related to HIV incidence in the United States

... based on historical data and is not a prospective trial of prevention effectiveness. Therefore, it is subject to methodological limitations. Nevertheless, he said it provides substantial indications of a strong relationship between the amount of national investment in HIV prevention and levels of new infe...

Virginia Tech's System X supercomputer provides super tool for simulation of cell division

...ler models whose parameters could be determined by trial and error, a process modelers call "parameter twiddling." But he and his coworker, Kathy Chen, wanted to characterize all the protein interactions regulating the cell cycle of budding yeast (the yeast cells familiar to bakers and brewers, and a favor...

Mechanical 'artificial hearts' can remove need for heart transplant by returning heart to normal

... step for the researchers is a larger multi-centre trial named the Harefield Recovery Protocol (HARP) study, which is envisaged to start soon on both sides of the atlantic. The researchers are also continuing their molecular and cellular research and studying the mechanistic and therapeutic targets which ...

Single molecule extends fat mice lives by reversing gene pathways associated with disease in obese

...on this paper and which is currently in a phase 1b trial in humans with diabetes using an enhanced, proprietary formulation of resveratrol. [Harvard has license and equity interests with Sirtris, which is not a public company.] Investigators identified resveratrol while looking for compounds that activat...

Backache beaten by good vibrations?

...ral health before the trial, immediately after the trial and again six months later. Dr McCarthy explain...dition." The study is a double blind randomized trial with both the volunteer and treating physiotherapist unaware of the treatment allocation. ...

End-of-life care can be improved

...ith chronic, life-limiting diseases will opt for a trial of intensive care. Critical care researchers are taking the lessons learned from previous observational studies and using them to develop and test generalizable interventions that improve the quality of ICU end-of-life care. The Critical Care Med...

UCSF study will test new vaginal microbicide for herpes and HIV

...ave them at all. Moscicki said that the safety trial is important because earlier spermicidal microbicides like nonoxynol 9, which was an ingredient in a variety of contraceptive products from condoms to contraceptive creams and gels, was eventually found to increase rather than decrease HIV infection ...

Radiation after surgery doubles survival time for some lung cancer patients

... surgery. "This is the first time that a clinical trial has examined the effectiveness of radiation after ... needs to be confirmed in a prospective randomized trial of radiation, in addition to chemotherapy." ...

Antibiotic treats lymphoma of the eye

... rate of disease-free survival. "Our prospective trial revealed that doxycycline is a fast, safe, and active treatment for OAL, both at initial diagnosis and at relapse," the authors write. In an accompanying editorial, Emanuel Zucca, M.D., and Francesco Bertoni, M.D., of the Oncology Institute of Sout...

Male contraception: One door opens, another closes

...Lissner cites the recently opened Intra Vas Device trial as proof. The long-term male contraceptive is bein...itutes of Health grant. Due to popular demand, the trial has been expanded to four U.S. cities and can accept 90 participants. Similar approaches have been s...

HIV-1 kills immune cells in the gut that may never bounce back

...Saurabh Mehandru, and their colleagues report on a trial of 40 HIV-1 positive patients who began treatment with HAART shortly after contracting the virus -- during the acute early infection phase -- and who they followed from one to seven years. The researchers found that although the blood population of C...

Gene signature assesses breast cancer outcomes

...ctively tested in a larger study called MINDACT, a trial coordinated by the European Organization for Research and Treatment of Cancer. This trial will assess whether the 70-gene signature can better identify who can safely be spared adjuvant chem...

LSD treatment for alcoholism gets new look

...tudy) after taking one dose of LSD. The controlled trial also concluded that less than 25 per cent of alcoholics quit drinking for the same period after receiving group therapy, and less than 12 per cent quit in response to traditional psychotherapy techniques commonly used at that time. Published in th...

New technology to speed up research into Huntington's disease

...st how effective the test was and already clinical trial companies are showing an interest in the touch screen system". ...

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