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Tag: "treated" at biology news

'Trojan Horse' agent halts bone metastasis in mice

... to simulate a bone metastasis. A week later, they treated the animals with five staggered doses of VEGF121/r...ed through intravenous injections. Half of the treated mice did not develop any bone tumors, Rosenblum says. "There was no evidence of cancer growth," he s...

U-M researchers use nanoparticles to target brain cancer

... light. In rat studies, researchers found those treated traditionally with Photofrin survived 13 days, while rats treated with Photofrin incorporated into a nanoparticle survived an average of 33 days. Forty percent of the...

Successful lung cancer surgery not enough to break nicotine dependence in many smokers

...Anderson Cancer Center enrolled 154 patients being treated for early stage lung cancer at their centers. These patients were lucky, Walker said. "Their cancer was discovered largely by accident when they were being examined for other medical conditions, and so was potentially curable by surgery," he said. "M...

High-throughput oncogene mutation detection in human cancers by mass spectrometry-based genotyping

... for one form of lung cancer. These cancers can be treated with the targeted therapies Gleevec and Tarceva, respectively, which shut down the affected oncogenes. The test involves taking a sample of fresh or frozen tumor, amplifying its DNA, and then searching for 250 known mutations in 17 oncogenes. (These...

Older men treated for early prostate cancer live longer than those who are not

...he 44,630 men, 32,022 (71.8 percent) were actively treated with either surgery or radiation therapy during the first six months after diagnosis. The remaining group of 12,608 (28.3 percent) were classified as having received "observation" and did not undergo surgery, radiation or hormonal therapy. During ...

Leading reason for corneal transplants comes into focus

... interested in FCD more than six years ago when he treated a woman with a corneal dystrophy of unknown origin that looked remarkably similar to FCD despite slightly different symptoms. "I knew it wasn't classic Fuchs, but rather something new," remembers Gottsch. "In the end, it wasn't Fuchs at all, but a so...

A fisheye view of the deadliest breast cancer

... aquariums around the world, which was chemically treated to be immune suppressed. In recent years, the zebrafish has vaulted to the top as a laboratory model organism. The zebrafish is tough, easy to breed, and a vertebrate, just like us. Being immune suppressed, the transgenic fish allowed Konstantin St...

New engineered drug may offer prolonged arthritis relief

... to infection is a particular problem for patients treated for chronic diseases such as osteoarthritis, and t...activity and fight inflammation. The researchers treated human white blood cells with either the original or the modified drug. White blood cells are respons...

Human stem cells delay start of Lou Gehrig's disease in rats

...fect disease progression. Both groups of rats were treated with drugs to prevent transplant rejection. The rats were weighed and tested for strength twice a week for 15 weeks. Weight loss, according to Koliatsos, indicates disease onset. On average, rats injected with live stem cells started losing weigh...

Abnormal overexpression of p53 is a predictive molecular biomarker

...HN patients have found that 18 percent of patients treated with Advexin achieved local regional disease control. Two other phase III trials in the disease are underway. According to Introgen's published research, Advexin has also achieved 100 percent response when combined with chemotherapy to treat locally ...

Adolescent but not adult hamsters are more aggressive on low dose of fluoxetine

...outs and target of attack. The adult hamsters treated with either dose of fluoxetine became generally more peaceful, attacking less often and for shorter times. However, the juveniles responded differently, both to high and low doses. The low doses actually resulted in significantly longer, more frequ...

Experimental cancer drugs counter muscle deterioration seen in muscular dystrophy

...es. Indeed, muscles examined from dystrophic mice treated with Trichostatin A for three months displayed normal tissue architecture, as compared to the muscles examined from untreated, dystrophic mice. Furthermore, dystrophic mice receiving treatment were able to perform physical exercise (e.g. running on a...

Effective HIV control may depend on viral protein targeted by immune cells

...st 600 South African patients who had not yet been treated for their HIV infections. The researchers comprehensively mapped the CD8 responses against all viral proteins and also investigated whether the versions of HLA Class I molecules involved in the immune system’s recognition of HIV protein fragment...

Brain protein improves stroke symptoms in rats, even when injected after 3 days

...s after the stroke, for a period of ten days. Rats treated with G-CSF for ten days after the stroke performed...abilities and coordination than rats that had been treated with placebo. ...

Therapeutic role found for carbon monoxide

...t the role of the nitric oxide, the co-culture was treated with a select inhibitor of NOS3. Under these conditions, he adds, CO was unable to induce death to the same degree as in control-treated co-cultures. "We concluded that the physical interaction between the two cell types plus the ability to generate...

Gene therapy for hereditary lung disease advances

...Alpha-1 patients with symptoms of emphysema can be treated through weekly intravenous injections of alpha-1 protein derived from human plasma. The injections must continue throughout a patient's life, according to the American Lung Association. It does not cure, but it does appear to slow the progression of ...

Changing length of days reverses how estrogen affects aggressiveness in mice

...led their testosterone levels. The males were then treated with a drug known as an aromatase inhibitor, which halts the production of estrogen. This class of drugs is commonly used to treat estrogen-dependent breast cancer. In mice housed in short days (limited daylight as in winter), the drug halting est...

Gene chip technology shows potential for identifying life-threatening blood infection

...d more accurately triage patients so they could be treated earlier with the appropriate antibiotic," Cobb says. The researchers used microarrays, also called gene chips, to analyze patterns of gene expression in the mice. The same technology is already used by doctors to diagnose breast cancer and predict...

New data from NIH lab confirms protocol to reverse type 1 diabetes in mice

...the 2001 and 2003 studies, Faustman and colleagues treated end-stage nonobese diabetic (NOD) mice with Freund's complete adjuvant, a substance that suppresses the activity of the immune cells that destroy islets in type 1 diabetes. They also introduced donor spleen cells to retrain the immune system not to ...

Cancer stem cells linked to radiation resistance

... In another set of experiments, the researchers treated both the test animals and the cell cultures with a drug, called debromohymenialdisine, which is known to inhibit the proteins involved in the activation process. They added the drug before and after radiation treatment and measured the number of surv...

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