Decisions, decisions: Male or female?
...e findings could eventually help us understand and treat defects in germ cell development that lead to human infertility and disease." ...Novel plague virulence factor identified
...ld improve our ability to develop new medicines to treat such diseases." Aballay has used the C. elegans, a worm commonly found in the soil, as a model to study the virulence mechanisms of other bacteria besides plague. The worm is an ideal model for genetic studies, he said, because it takes only three d...New Look at DNA Hints at Origin of UV Damage
...ld improve our ability to develop new medicines to treat such diseases." Aballay has used the C. elegans, a worm commonly found in the soil, as a model to study the virulence mechanisms of other bacteria besides plague. The worm is an ideal model for genetic studies, he said, because it takes only three d...Disease diagnosis, bioengineering covered at state nano summit
... mere molecule may soon become a potential drug to treat HIV, one of the diseases he actively targets with his research. ...Drug Offers Alternative to Surgical Treatment After Miscarriage
...ast few years, physicians have used misoprostol to treat pregnancy failure, and some researchers have conducted a few small studies of the drug’s effectiveness in treating that condition. However, no definitive evidence existed to determine whether the drug was safe and effective enough for routine medical...Sleeping Sickness Epidemic Spreading in Uganda
...ast few years, physicians have used misoprostol to treat pregnancy failure, and some researchers have conducted a few small studies of the drug’s effectiveness in treating that condition. However, no definitive evidence existed to determine whether the drug was safe and effective enough for routine medical...Variation in HIV's ability to disable host defenses contributes to rapid evolution
... of the reasons HIV is so difficult to contain and treat is its rapid evolution. Understanding how host defenses and viral countermeasures contribute to that evolution is vital. Host cells produce two proteins that mutate HIV DNA and interfere with the virus's ability to replicate. But HIV produces a prot...Study shows how retinoic acid enters a cell's nucleus
..., past clinical trials have shown that RA can help treat leukemia, head, neck and breast cancer. RA and its synthetic derivatives may also be useful in treatment of diabetes, arteriosclerosis and emphysema. Unfortunately, conventional treatments using RA require high, toxic doses, and tumors can develop re...Gene expands malaria's invasion options
...ontain a sugar known as sialic acid. If scientists treat blood cells with an enzyme to remove sialic acid, the parasite can no longer invade. Other strains - including one called W2mef - can invade using the sialic acid receptors, but also have the ability to switch to other pathways if necessary. "It's ...Doctors should stop prescribing antibiotics for the common cold, review advises
... there may be some benefit of using antibiotics to treat the runny nose with colored discharge (acute purulent rhinitis), "their routine use is not recommended," the review says. Colds are the most common reason for new patient visits at general practioners' offices, the review reports, and although the a...Researchers track down cause of a disfiguring bone disorder
...ents that can be used as new therapeutic agents to treat individuals suffering from bone loss disorders" such as osteoporosis. "Therefore the findings stemming from this collaboration, along with the mouse models created, have clinical relevance in addition to addressing a fundamental problem in genomics."...Redesigned protein accelerates blood clotting
..."A more potent form of factor VIII, one that could treat effectively with a lower dose, would reduce the cost and, potentially, avert immune reactions," Fay said. Study Details Blood clotting involves more than a dozen clotting factors, many named with roman numerals. They form a cascade of chemical reac...Most common lung cancers may begin in newly discovered cells
... origins of diseases and to develop better ways to treat them." ...Tetanus toxin found to have therapeutic properties
... These have been successfully used as a therapy to treat disorders caused by abnormal muscular contractions such as strabismus, cerebral palsy, anal contractions and torticollis. Recently these toxins have been used even in cosmetics against wrinkles. For these therapeutic and cosmetic applications, the sc...NIH renews network focused on how genes influence drug responses
...en and hormone treatments frequently prescribed to treat breast cancer. (David A. Flockhart, M.D., Ph.D., I...onses to anticancer drugs, including those used to treat childhood leukemia and colorectal cancer. (Mark Ratain, M.D., University of Chicago, and Mary V. Rel...Scientists show that tick-borne flaviviruses use a novel mechanism to evade host defenses
...ions that it is being tested in clinical trials to treat infection with various flaviviruses. But the treatment appears to fail in about half of cases. Dengue virus, West Nile virus and yellow fever virus have a protein called NS4B that prevents interferon from functioning properly. It was thought that th...Compound from Chinese medicine shows promise in head and neck cancer
...isplatin, a platinum-based drug frequently used to treat this type of cancer. They found cisplatin killed cells with a mutant form of the protein p53, but cells with normal p53 and high levels of Bcl-xL were resistant. The researchers then treated these cisplatin-resistant cell lines with (-)-gossypol and ...Secrets to antibody's success against West Nile Virus surprise scientists
... fever. A monoclonal antibody that can effectively treat mice infected with West Nile virus has an intriguing secret: Contrary to scientists' expectations, it does not block the virus's ability to attach to host cells. Instead, the antibody somehow stops the infectious process at a later point. "This was...Slipping past the blood brain barrier: Research shows potential treatment for brain cancer
...nto mice but let much of it pass into the brain to treat cancer. "The blood brain barrier is set up to ver...use they show a way to get drugs into the brain to treat cancer. "There are times when there's a big difference between an animal model and the human condi...HIV Therapy Greatly Extends Life of Key T Cells, Scientists Find
...ted with various side effects, IL-2 is licensed to treat certain cancers. NIH researchers have long observed that in responsive patients, intermittent cycles of IL-2 therapy lead to substantial increases in the number of circulating CD4+ cells. The mechanisms driving this increase as well as its potential...