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Tag: "transporter" at biology news

A potential biological cause for sudden infant death syndrome

...evidence for insufficient amounts of the serotonin transporter protein, which "recycles" serotonin so that nerve cells can reuse it. "We provide strong evidence that SIDS is a biological problem, and that the brainstem serotonin system is a good place to focus continued research efforts," says Paterson....

Breakthrough in understanding type-2 diabetes as key genes identified

...pe-2 diabetes have a mutation in a particular zinc transporter known as SLC30A8, which is involved in regulating insulin secretion. Type-2 diabetes is associated with a deficiency in insulin and the researchers believe it may be possible to treat it by fixing this transporter. Professor Philippe Froguel, on...

Elucidation of the genome for diabetics with DNA chips

...to DT2 have been identified. They include the zinc transporter of pancreatic insulin-secreting cells (ZnT8), whic... identified in this study, including the ZnT8 zinc transporter gene in particular, may be good targets for treatments to combat DT2. These results from the anal...

New mechanism for nutrient uptake discovered

...ed C-terminus, of the protein Arabidopsis ammonium transporter AtAMT1;1, located at the surface of the cell membrane, acts as a switch. "The terminus is an arm-like feature that physically grabs a neighboring short-chain molecule, binds with it, and changes the shape of itself and its neighbor thereby activat...

Technology reveals 'lock and key' proteins behind diseases

...eract with and presumably communicate with the ABC transporter Ycf1p, a yeast version of the human proteins CFTR ...t one of these interactors, Tus1p, regulates Ycf1p transporter function in a completely novel way to stimulate its ability to remove toxins from the cell. "The...

Bisexual fruit flies show new role for neurochemical

...ount of ambient glutamate in the brain. Called xCT transporter proteins, they pump glutamate out of glia cells. "When we mutate the protein, we get less ambient extracellular glutamate, more glutamate receptors, and so a stronger transfer of messages at synapses," Featherstone said. The gene mutation also ma...

Navigable nanotransport

... species that are recognized by cells, showing the transporter the way to reach its goal, such as a tumor cell. To demonstrate the power of their new concept, Kim and his team chose rigid, disk-shaped monomers equipped with a ring of special molecular "hooks" that can be activated by UV light. When a solution...

Simulations unravel outer membrane transport mechanism

... inner membrane protein, TonB. This TonB-dependent transporter (TBDT) contains a beta-barrel domain: a series of parallel sheets that form a tunnel through which large molecules can pass. Another region of the protein, the luminal domain, clogs this barrel until the cell is ready to allow large molecules to pass...

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