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Tag: "transporter" at biology news

Key Trigger Of Opioid Withdrawal Symptoms Found

...ractive. The scientists' analysis revealed that a transporter molecule for the neurotransmitter GABA was respons...machinery involved in activating the abnormal GABA transporter activity. Importantly, the researchers found that drugs that inhibit either the GABA transporter ac...

Potential Drug Target For Treating Cocaine Abuse Found

...molecule that would block cocaine's effects on the transporter without inhibiting the transporter by itself," notes Eric Nestler, chair of psychiatry at the University of Texas Southwestern Medical ...

NIH Researchers Discover How Insulin Allows Entry of Glucose Into Cells

... the study, the researchers discovered how glucose transporter 4 (GLUT 4) carried insulin into fat cells. Previously, scientists had learned that, within the cell, GLUT 4 is contained in the membrane of tiny sacs known as vesicles. Another author of the current study, Samuel Cushman, Ph.D., of NIDDK’s Diabetes ...

New polysaccharide may help combat multidrug resistance in cancer

...n increases the cellular production of a multidrug transporter protein by binding to CD44. They discovered that antagonist molecules that bind to hyaluronan and prevent it from interacting with CD44 were able to sensitize multidrug resistant breast cancer cells to chemotherapeutic drugs. The researchers also fou...

'EuroVacc 02' HIV Vaccine Trial Begins

...reactions to, and the consequent inhibition of the transporter are reduced. The first injections prime the immune system whereas the second injections further enhance (boost) the immune response. Therefore this combined vaccine strategy is expected to strengthen stimulation of the immune response While there is...

Depression gene may weaken mood-regulating circuit

...this circuit, which is influenced by the serotonin transporter gene." Since serotonin activity plays a key role in wiring the brain's emotion processing circuitry during early development, the researchers propose that the short variant leads to stunted coupling in the circuit, a poorly regulated amygdala respon...

Mechanism for the captation of nutrients in plants- unknown to date

...tance has its specific transporter, or even if one transporter can recognise 3 or 4 different substances, an infi...st 90 minutes, the saccharose penetrates using the transporter mechanism while, parallely, the endocitosis phenomenon is activated to form microvesicles. Subsequen...

Plant gene related to cancer treatment may foster new oncology drugs

...ecules are mediated by interaction between the PGP transporter proteins and PIN facilitator proteins," Murphy said. ...

Lactic acid not athlete's poison, but an energy source - if you know how to use it

...endurance training increased the number of lactate transporter molecules in mitochondria, evidently to speed upta...idence for the hypothesized connection between the transporter molecules - the lactate shuttle - and the enzymes that burn lactate. In fact, the cellular mitochond...

Forsyth scientists gain greater understanding of how embryos differentiate left from right

...asymmetry and identified a novel component: an ion transporter that creates strong natural voltage gradients and ...rlier than expected in frogs by identifying an ion transporter that generates natural bioelectrical signals that ultimately control gene expression and the positio...

Are dancers genetically different than the rest of us? Yes, says Hebrew University researcher

... two genes that provide the code for the serotonin transporter and arginine vasopressin receptor 1a. Both genes... of information between nerve cells. The serotonin transporter regulates the level of serotonin, a brain transmitter that contributes to spiritual experience, amon...

Dying of excitement

..., is a mutation in the gene encoding the glutamate transporter protein EAAT2. This mutation --- a single nucleotide change in the promoter region of the EAAT2 gene -- was equally prevalent in healthy individuals and stroke patients. But among stroke patients, those with the mutated allele had higher plasma lev...

Genetically altered mice no longer like cocaine

...University . The study confirms that the dopamine transporter ?a protein that moves the neurotransmitter dopamin...e transporter. "By doing so we created a dopamine transporter that resists cocaine but also retains its function of taking up dopamine and carrying it back to the...

Johns Hopkins lab scientists tame overactive CF protein

... 97 (valosin containing protein), kills a chloride transporter in the cells of the vast majority of CF patients, but quieting the protein restores the cells' ability to transport chloride in and out, researchers found. The inability to transport chloride is the hallmark of CF that causes dangerous buildup of thi...

Metal homeostasis research in plants will lead to nutrient-rich food and higher yielding crops

...s lab has previously identified the essential Iron transporter responsible for Iron uptake from the soil. This Iron transporter is IRT1. In addition to transporting iron, IRT1 can also transport Manganese, Zinc, Cobalt and Cadmi...

New study reveals structure of E. coli multidrug transporter protein

...rters like EmrD. Determining the structure of this transporter will add significantly to our general understandin...al structural features across multi-drug resistant transporter families." Other authors of the study include Yong Yin, Xiao He, Paul Szewczyk, and That Nguyen of ...

New finding points way to foiling anthrax's tricks

...- that snatch iron away from the human body's iron transporter molecules, called transferrin. These scavengers, or "siderophores," are essential to anthrax's ability to grow rapidly, especially after the spores are inhaled, though why the bacteria need two siderophores to do the job has been an enigma. The ne...

High dopamine transporter levels not correlated with ADHD

...ol subjects. "These results suggest that dopamine transporter levels alone cannot account for the severity of sy...ranging from 70 percent to 5 percent elevations in transporter levels. Two other studies found no elevation of transporter levels, though one found a decrease in d...

How brain injury leads to seizures, memory problems

...bits that activity. "When lower levels of the KCC2 transporter weaken the dentate gyrus's ability to act as a gatekeeper," said Dr. Cohen, "neurons become more excitable, and seizures can occur." In addition to its role in inhibiting seizures, the dentate gyrus is also believed to be important in memory form...

Gene linked with mental illness shapes brain region, researchers find

...release serotonin, a molecule called the serotonin transporter (SERT) brings it back into the cell. Thus, seroton... treat patients with depression. The serotonin transporter gene has two forms, or variants: short, or SERT-s, and long, SERT-l. A person can have two copies of...

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