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Tag: "transplants" at biology news

Stem cells bring fast direct improvement, without differentiation, in acute renal failure

...stem cells similar to the type used in bone marrow transplants is "highly renoprotective, showing almost immediate improvement in both kidney function and degree of tissue injury, followed by accelerated regeneration and return of function," he said. Furthermore, "these beneficial effects are predominantly media...

Researchers identify genes associated with lung transplant rejection

...n to try and prevent it. But the problem with lung transplants is that it's hard to detect chronic rejection." Currently, he says, OB is best detected through a breathing test--but by the time the disease has a perceptible impact on the patient's ability to breathe, it's often too late to treat effectively. Cau...

Researchers create infectious hepatitis C virus in a test tube

...e due to hepatitis C is the leading cause of liver transplants in the United States, and about 25 percent of liver cancer cases in the country are associated with HCV. Although about 85 percent of those who are infected develop chronic infection, the virus usually remains undetected for years, or even decades, u...

New type of rejection blocker protects kidneys after transplant

...in this fall enrolling patients who receive kidney transplants from living donors at UCSF, will test whether transplant patients can be treated with belatacept and can gradually withdraw from all immunosuppressants -- including belatacept itself. In addition, Bristol-Myers Squibb Company, the pharmaceutical c...

Discoveries by UAB and Florida scientists may help transplanted organs survive longer

...rt because after several years, people with kidney transplants often lose function of the organ. With about 60,00...to evaluate the treatment to try to protect kidney transplants in non-human primates ?and if successful there, go on to clinical trials in humans, said Agarwal. ...

Stem cells in bone marrow replenish mouse ovaries

...e researchers found that bone marrow or blood cell transplants appear to completely revive the ovaries of female ...gg cells (oocytes) generated following bone marrow transplants can mature and be fertilized to give rise to viable mouse pups, the findings provide an important fi...

Researchers pioneer new gene therapy technique using natural repair process

...tened by systemic infection, and while bone marrow transplants can be used to treat the disease, they are not always successful. "SCID is ideal for this sort of therapy because you only need to correct the defect in a small number of immune cells to fix the problem," said Dr. Porteus, assistant professor of ped...

Precise Timing Enabled Pig-to-rat Transplants To Cure Diabetes

...n and Rogers have demonstrated that the pancreatic transplants aren't altering the rats' immune systems. They showed that rats with successful pancreatic transplants still reject a transplant of a different type of pig primordia, embryonic kidney tissue, if they are...

Single-donor Islet Transplantation Procedure Shows Promise For Patients With Type 1 Diabetes

...hat produce insulin to control blood sugar levels) transplants has recently been increased markedly by transplant...d from 2 to 4 donor pancreases. However, for islet transplants to become a widespread clinical reality, additional advances are still needed. In particular, restor...

NHGRI targets 12 more organisms for genome sequencing

... studies; the LEW strain, often used in studies of transplants and immune response; the BB strain, used in studies of diabetes; the FHH strain, also used for cardiovascular studies; the DA strain, used for studies of arthritis and cancer; and the SHR strain, used in studies of hypertension. "The overriding goal...

Infants with Rare Genetic Disease Saved By Cord Blood Stem Cells

... best long-term outcomes and newborns tolerate the transplants more easily than older babies and children. "Time is of the essence in treating these children before symptoms progress and become irreversible," said Kurtzberg, director of Duke's Pediatric Blood and Marrow Transplant Program. "Delaying the transpl...

NIAID begins clinical trial of West Nile virus vaccine

...so can be spread through blood transfusions, organ transplants and breastfeeding, as well as from mother to child during pregnancy. Most people experience no symptoms or only mild symptoms, such as fever, headache and body aches; more serious cases can lead to infections of the brain and nervous system, such as ...

Infants With Rare Genetic Disease Saved by Cord Blood Stem Cells

... best long-term outcomes and newborns tolerate the transplants more easily than older babies and children. "Time is of the essence in treating these children before symptoms progress and become irreversible," said Kurtzberg, director of Duke's Pediatric Blood and Marrow Transplant Program. "Delaying the transpl...

Stem cells from brain transformed to produce insulin at Stanford

...ons. In rare cases, some patients can receive cell transplants from cadavers, but that source of cells is far smaller than the total number of people who could benefit. ...

World-first Living Donor Islet Cell Transplant A Success; Procedure Offers Promise For Diabetics

...kidney transplantation there. "Living donor islet transplants could allow many more desperate patients with type 1 diabetes to get successful islet transplants," says Dr. Shapiro. "The donor operation is relatively safe, but is not entirely devoid of serious potential risk," he added. A shortage of donor islet...

Circles Of DNA Might Help Predict Success Of Stem Cell Transplantation

...Physicians sometimes treat patients with stem cell transplants as part of therapy for a variety of diseases such ...e them with healthy stem cells from donors. If the transplants succeed, the donated stem cells repopulate the blood with healthy red and white cells. The St. Jude...

Potential Cure for Lymphoma in HIV patients

Stem cell transplants have become thestandard of care for patients with relapsed lymphoma, but not forpatients who suffer from both this disease and HIV. A new study showingthat this treatment is a viable option for select patients withHIV-associated lymphoma will be publ...

Gene therapy converts dead bone graft to new, living tissue

...one. This has proven successful for the small bone transplants used in spinal fusion, but not for larger grafts, because the proteins' effectiveness wear off in just hours. By contrast, the gene therapy method triggers the tissue surrounding the graft to produce the proteins continuously for up to three weeks, l...

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