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Tag: "transplants" at biology news

New compound reduces stroke damage

...graf®) is often administered to patients receiving transplants to prevent organ rejection. Dervatives of the drug are also commonly used in the treatment of autoimmune diseases. FK506 inhibits T-cell activation by binding to members of the FK506-binding protein (FKBP) family. Interestingly, FK506, and several mo...

Successful transplantation from pig embryos to mice

...rticularly those afflicted with juvenile diabetes, transplants of the pancreatic tissue in which insulin is produ...munology Department has brought the possibility of transplants from pig embryos one step closer. The results of the study appeared in the June issue of PLoS Medici...

Can you hear me now? Scientists find previously unknown receptors on adult stem cells

...fections after receiving bone marrow or cord blood transplants or inautoimmune diseases like lupus, where immunosuppressive treatments oftenleave the body subject to long-term infection. Scientists need tostudy stem cells and leukemia cells in these diseases to determine if theyare using this messaging system,"...

Neurons grown from embryonic stem cells restore function in paralyzed rats

For the first time, researchers have enticed transplants of embryonic stem cell-derived motor neurons in th...ng signals from myelin. Some animals also received transplants of neural stem cells that secreted the nerve growth factor GDNF into the sciatic nerve (the sciatic ...

Predicting successful outcomes in living-donor liver transplants

...sed on ICG elimination immediately following liver transplants should have a large impact on further improving LDLT outcomes, since appropriate clinical management can then be instituted if necessary. In another study in the same issue, researchers led by Christoph Jochum, M.D. of the University Duisberg-Essen ...

Stem cell transplants improve recovery in animal models for stroke, cerebral palsy

...c potential clinical scenarios for stroke victims, transplants were performed seven days after the intitial injur...s, from the same species, and gentically identical transplants yielded essentially equal results.Athersys, Inc., a Cleveland-based biopharmaceutical company pursui...

Pennsylvania researchers find liver transplants provide metabolic cure for rare genetic disease

Liver transplants cured the metabolic symptoms of 11 patients with a...ldren's transplant surgeons began performing liver transplants on MSUD patients in May 2004. Children's has performed 18 MSUD liver transplants since then. The st...

U of S researchers develop new vaccine candidate against hepatitis C

...he infection." HCV is the leading cause for liver transplants in the western world, and its annual death toll is expected to triple in the next 10 years. Worldwide, there are about five times more people infected by HCV than with the HIV virus. Treatment of hepatitis C, which like HIV is spread by blood-to-bloo...

How can we protect patients with weakened immune systems from influenza?

...m cell transplant. Both chemotherapy and stem cell transplants involve suppressing the patients' immune defenses....involve cancer patients: those receiving stem cell transplants for multiple myeloma (a cancer originating in bone marrow) and patients with ovarian cancer receivin...

Potential heart benefit found in stem cells

...ults help explain the positive impact of stem cell transplants for heart patients, demonstrating that they do, in fact, work to thicken the heart wall," said Eckhard Alt, M.D., of Tulane University and lead author of the study. "We believe that stem cells from the adipose tissues may be a valuable novel alternat...

Illinois pig to make history as source of first complete swine genome

...ead to biomedical advances, including pig-to-human transplants and disease treatments. "This grant represents the efforts of many colleagues around the world," Schook said. "We were very fortunate to be able to conduct research that provided the opportunity to assume this leadership position. Clearly this is a ...

Scientists discover that widely available drug also helps fight kidney disease

... formation, and most ADPKD patients require kidney transplants or life-long dialysis for survival, explained Thomas Weimbs, director of the laboratory where the discovery was made. Weimbs is assistant professor in the Department of Molecular, Cellular and Developmental Biology at UCSB. The scientists studied th...

Powerful technique for multiplying adult stem cells may aid therapies

...mendous promise for treatments such as bone marrow transplants and perhaps even gene therapy. "A 30-fold increase is ten times higher than anyone's achieved before," says Lodish, senior author on the paper, which will be published January 22 online in Nature Medicine. Unlike embryonic stem cells, adult...

Carnegie Mellon develops non-invasive technique to detect transplant rejection at cellular level

... USPIO particles into rats that had received heart transplants three days earlier. Macrophages, which typically ingest foreign materials inside the body (bacteria, for example), incorporated the particles. Using MRI, the researchers then track tagged macrophages that infiltrate transplanted hearts. The locations...

Stem cells from muscles can repair cartilage

...om juvenile rats and other studies have shown such transplants to be problematic in adults. She concludes: "Thus, further work is warranted to determine the chondroprogenitor potential of MDSCs in adult humans and their capacity to form cartilage in vivo." ...

New cell transplantation technique restores insulin production in diabetics

...rly controlled type 1 diabetes. Fifteen islet cell transplants were completed-two patients underwent two procedures to achieve correct needle placement. "We used a steroid-free protocol to suppress the immune system, so that the body accepted the transplanted cells," Dr. Krishnamoorthy said. "We also developed ...

'License to kill' enables powerful immune attack cells in mice

...ama says. "It could also help us match bone marrow transplants in a way that increases the immune system's ability to fight off a relapse of the leukemia." ...

U-M scientists discover identifying markers for primitive blood-forming stem cells

...tion of such cells, potentially making bone marrow transplants safer and more effective," says Morrison, who adds that Kiel and Yilmaz have already started tests to look for them. Toshide Iwashita, M.D., Ph.D., a former research fellow in Morrison's laboratory and co-first author on the study, was responsible f...

Fish and chips: A fast track to understanding blood development

...he University already perform umbilical cord blood transplants to treat disease. But there are often not enough blood stem cells harvested from a single collection of umbilical cord blood to effectively treat adults and older children. This research provides insight into understanding how to stimulate blood stem...

Israeli scientists successfully transplant frozen-thawed ovaries in sheep

...heir treatment," she said. Whole ovary autologous transplants have already been attempted twice in women ?in 1987 and 2004 ?in both cases into the upper arm, but in neither case was the ovary frozen and thawed first[2]. Another much-researched option is freezing and transplanting thawed ovarian tissue. Two bab...

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