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Tag: "translational" at biology news

Affymetrix and the Karolinska Institutet Announce Translational Medicine Strategic Alliance

... about the potential of this agreement to move the translational medicine field forward." Karolinska Institutet agreement is part of the Affymetrix Translational Medicine Initiative. The goal of the initiative is to bridge the gap between clinical research and application of genomics in patient care by bringing t...

Researchers test new therapy for advanced melanoma

...USF and Moffitt in this trial is a good example of translational research -- moving the new application of a gene transfer technology from an animal model to the patient. Dr. Heller's team worked extensively with Dr. Daud to adapt the electroporation technique used on mice to humans. The researchers injected the ...

Drug Offers Alternative to Surgical Treatment After Miscarriage

...for conducting and supporting basic, clinical, and translational medical research, and investigates the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov. ...

Sleeping Sickness Epidemic Spreading in Uganda

...for conducting and supporting basic, clinical, and translational medical research, and investigates the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov. ...

North & South American researchers find architectural abnormalities in T. cruzi ribosome

...nown there was something strange about the genetic translational machinery of the Chagas parasite. Unlike in other organisms, an identical string of 39 nucleotides is spliced onto the lead end of every mRNA molecule, no matter which protein is to be made. And, as Levin and his colleagues discovered years ago, the ...

Bacteria in Household Dust May Trigger Asthma Symptoms

...for conducting and supporting basic, clinical, and translational medical research, and investigates the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov. ...

How can we protect patients with weakened immune systems from influenza?

...from dendritic cells. Carl June, M.D., director of translational research at Penn's Abramson Cancer Center, leads both projects. A third group of adult patients suffers from autoimmune diseases, those in which an abnormal immune system turns on itself: systemic lupus erythematosus and Sjogren's syndrome. Core r...

Malignant melanoma cells secrete protein required for embryo formation

...morigenic and embryonic signaling pathways. From a translational perspective, Nodal signaling provides a novel target for treatment of aggressive cancers such as melanomas," said Mary J. C. Hendrix, the corresponding author, of Children's Memorial Research Center where the discovery was made. Hendrix is preside...

Breast stem cells have features similar to 'basal' tumors

...pital campus is strongly committed to this type of translational research. Our hope is that this will lead to better cancer outcomes from a disease that strikes one in 11 Australian women."The team findings are published in the 19 July 2006 issue of the Journal of the National Cancer Institute. ...

'Sticky' mice lead to discovery of new cause of neurodegenerative disease

...in human populations is whether the subtle loss of translational fidelity from such a defect could lead to various human diseases ?particularly those that involve the accumulation of misfolded proteins," she said. Ackerman and her colleagues are conducting further studies to understand why Purkinje cells are ...

A splice of the action: Translational role for WT1 isoform

...to identify genes that are regulated by WT1 at the translational level and the role that this type of regulation plays in normal development and disease." ...

Pair of microRNA molecules controls major oncogene in most common leukemia

... even know whether they work on transcriptional or translational level," he said. "But finding that they control this cancer’s major risk factor is a very helpful advance." ...

Key to acute lung injury lies in Ang2 protein

...d the study is an example of true bench-to-bedside translational research. "All the work was initially done on mice in which we found that the Ang2 protein was involved in HALI," said Bhandari. "We also defined how the protein creates lung injury and then we showed its clinical relevance by documenting its presenc...

First Quantum Grant to fund stem cell repair of damage from stroke

...dmap for the development of multi-disciplinary and translational science. The BCM team also includes project co-developer Mary Dickinson, assistant professor of molecular physiology and biophysics at BCM; Dr. Thomas Zwaka, assistant professor of molecular and cellular biology in the Center for Cell and Gene The...

New cigarette designs don't offer lower predicted cancer risks

...y. The Cancer Institute is actively supporting the translational research of projects of Dr. Pankow designed to biologically confirm his epidemiological studies." Pamela Clark, Ph.D., senior research scientist at Battelle Centers for Public Health Research and Evaluation in Baltimore, said Pankow's study "has p...

Researchers first to map gene that regulates adult stem cell growth

...g way," Van Zant said. "This is a great example of translational research ?from the most basic type of genetic research all the way to possible treatments for patients." One big obstacle chemotherapy patients face is stem cell loss after treatments. This limits the dosage amount and types of chemotherapy that c...

Massey researchers induce cell death in leukemia

...Steven Grant, M.D., Massey's associate director of translational research, interactions between bortezomib and romidepsin (Gloucester Pharmaceuticals) and bortezomib with belinostat (aka PXD101 from CuraGen Corporation and TopoTarget A/S), were examined in human CLL cells isolated from five patients. Bortezomib dr...

New compound prevents alcoholic behavior, relapse in animals by blocking stress response

...search Institute. "It moves the field over another translational barrier, closer to the day when the dark side of addiction is treated." The new findings build on previous work showing the effectiveness of blocking certain CRF receptors—proteins that bind CRF and make it active—in treating alcohol dependence i...

Researchers shed light on mechanism of action used by anti-cancer drug

...teven Grant, M.D., Massey’s associate director for translational research and co-leader of the cancer center’s cancer cell biology program, VCU researchers identified a mechanism by which sorafenib inhibits protein translation, and which may be involved in reducing expression of pro-survival factors, such as Mcl-1...

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