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Tag: "trafficking" at biology news

Nano-Probes Allow an Inside Look at Cell Nuclei

...ated with a protein that binds to a cell's nuclear trafficking mechanism, a ploy that gives the virus an unhinder...ens the door for real-time observations of nuclear trafficking mechanisms. They also hope to target other cellular organelles besides the nucleus, such as mitochon...

Shutting down the HIV assembly line

...specific piece of the AP-3 subunit, eliminated Gag trafficking to the multivesicular body and diminished HIV part...r body and in demonstrating that if you block that trafficking step specifically, you block production of particles," Spearman said. "That says this is not a dead-...

Retroviral resistance gene found

...erexpression of FEZ1 interferes with intracellular trafficking of the viral preintegration complex and traps the viral DNA in the cytoplasm. We hope that learning more about this transport machinery might reveal a new target for antiviral drugs in the treatment of HIV-1 disease." ...

Discovery of T-cell 'traffic control' boosts new drug promise

...arify how one of the body's molecules controls the trafficking of T cells through the blood, lymph nodes and on t...g. Goetzl has also shown that S1P regulates T cell trafficking by occupying a receptor on the T cell surface that suppresses the cells' normal response to a "forwa...

Continued reduction in the number of drug-related deaths in the UK

...ue to do everything possible on prevention of drug trafficking and the protection of our young people from the scourge of drug abuse problems" ...

APS lecturer shows rare video of 'teacher-student' immune cell interactions in live animal

...em, while cumbersome, works because of the amazing trafficking where they circle around and look for the presence of anything that might tickle their antigen receptor," von Andrian said. If the T cells don't recognize the antigen, they hop back in the blood stream and head for the next lymph node. T cells and B...

Newly identified protein complex sheds light on axon growth mechanism

... in a protein complex likely to be involved in the trafficking of vesicles along axons - a process that drives axon growth and helps synapse formation. The research also shows that UNC-69 is directly involved in the formation of new synapses. A group led by Michael Hengartner, from the University of Zurich in S...

Parkinson's disease mechanism discovered

...That study showed that genes enhancing ER-to-Golgi trafficking prevented alpha-synuclein toxicity. In particular,...ein, called Ypt1p, which is involved in regulating trafficking could also be switched on to suppress alpha-synuclein toxicity in yeast cells. "Our findings indica...

Molecular mechanism provides intra-cellular traffic signal

...Illinois at Chicago have found that intra-cellular trafficking is tightly coordinated for maximum flow through cellular compartments -- much as vehicles on a crowded road are allowed to pass quickly through a succession of green traffic lights. The molecular mechanism that underlies this coordination is repor...

Cellular traffic backups implicated in skeletal malformations

...ome of which might involve defects in this protein trafficking pathway. Knapik's model may provide insights into these disorders. "No craniofacial or skeletal deformities ?one of the most prominent human syndromes ?had ever been linked to that pathway," Knapik said. "I'm very excited that now we have an anim...

Researchers discover key mechanism by which lethal viruses Ebola and Marburg cause disease

...ver outbreaks, and increased international travel, trafficking in wildlife, political instability, and terrorism have made emerging infectious diseases a global concern," stated W. Ian Lipkin, MD, director of the Greene Infectious Disease Laboratory at the Mailman School's Department of Epidemiology and professo...

The biggest bug in gut discomfort

...en the late endosomal marker Lamp-1. Was C. jejuni trafficking to conventional lysosomes after all" To check, the researchers fed traceable dyes to infected cells. Taken up into the endocytic pathway, the fluorescent dyes co-localized with control bacteria known to traffic to lysosomes, yet surprisingly the dyes...

Prenatal cocaine's lasting cellular effects

...processes, suggesting that the altered D1 receptor trafficking may underlie the changes in neuronal architecture and behavior that Stanwood and others have previously observed. What remains to be determined, he cautioned, is whether D1 receptor localization is affected in humans exposed to cocaine prenatally...

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