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Tag: "toxicity" at biology news

Controversial drug shown to act on brain protein to cut alcohol use

... popular in the 1960s drugculture, and evidence of toxicity to certain nerve cells in rodentstudies have discouraged careful studies of its clinical potentialagainst drug and alcohol addiction. The FDA has not approved use ofIbogaine in the U.S.Scientists at UCSF's Ernest Gallo Clinic and Research Center have...

Clam embryo study shows pollutant mixture adversely affects nerve cell development

...k. They are currently examining the origins of BCE toxicity atthe single-neuron level to learn what genes are turned on and off bythe exposure to the chemical mixture. The research is focused on afamily of genes known as P53, which helps to regulate the cell cycle.They have also moved their studies to a new m...

Study identifies predictors of HIV drug resistance in patients beginning triple therapy

...k. They are currently examining the origins of BCE toxicity atthe single-neuron level to learn what genes are turned on and off bythe exposure to the chemical mixture. The research is focused on afamily of genes known as P53, which helps to regulate the cell cycle.They have also moved their studies to a new m...

First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers

...ice used in our trial seemed to experience minimal toxicity -- a good sign that patients might tolerate these compounds, too," Dr. Huang said. "It's all very exciting," he said. "Metastatic disease is such a tough problem, and these compounds could provide patients with a brand new kind of hope." The resear...

Nanogen Issued Patent for Electronic Microarray With Memory

... develop tests to detect infectious diseases, drug toxicity and mutations associated with cancer, cardiovascular and genetic diseases. The next generation instrument system, the NanoChip(R) 400, is expected to be available in 2005. Nanogen's subsidiary SynX offers a line of point-of-care diagnostic tests and ...

Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals

...me cohort of animals. The research showed no overt toxicity in the mouse brain from the MRI reporter. ...

Transgenic plants remove more selenium from polluted soil than wild plants, new tests show

...comes toxic at high doses. The dangers of selenium toxicity came to light in the 1980s when biologists discovered that irrigation drain water held at the Kesterson Reservoir in the San Joaquin Valley was causing serious deformities in birds. The researchers say cleaning up the sediment in the San Luis Drain ...

Gene Therapy Cures Inherited Liver Disease In Rats

...se vectors, long-term correction with no long-term toxicity is possible. We need to find a way to avoid short term toxicity." ...

Products containing specific probes for detecting alternative splice forms protected

...agnostics, and compound screenings for efficacy or toxicity as well as screening patients for potential efficacy of therapeutics. Alternative RNA Splicing is a critical step in the expression of most genes, which can result in the expression of several mRNAs encoding proteins with different functions from a ...

Survey finds silver contamination in North Pacific waters

...ncern. But silver is second only to mercury in its toxicity to marine invertebrates," Flegal said. Sam Luoma, a U.S. Geological Survey scientist who has worked with Flegal to study heavy metal contamination in San Francisco Bay, said the elevated silver concentrations in the open ocean suggest there may be "...

Turning viruses into allies against cancer

...rus. The results confirmed widespread infectivity, toxicity and destruction among these cells, probably through apoptosis or programmed cell death. When the modified virus was injected directly into human liver cancer cells grafted onto laboratory mice, scientists observed significant prolongation of life; c...

Researchers find promising cancer-fighting power of synthetic cell-signaling molecule

...not in the whole animal, or have unacceptably high toxicity for normal tissues," said Georgia Tech Professor of Biology Al Merrill. "Finding that Enigmols are effective in three animal models leads us to hope these may be a new approach to treat cancer." However, human trials must still be done to determine s...

Study uncovers bacteria's worst enemy

...active. The study's results indicate that actinide toxicity is primarily chemical, rather than radiological, a...other types of metals. This suggests that actinide toxicity will not impede bioremediation using naturally occurring bacteria. "This study" said Neu, "is excit...

Gene therapy cures inherited liver disease in rats

...se vectors, long-term correction with no long-term toxicity is possible. We need to find a way to avoid short term toxicity." ### Others who participated in this research include: Drs. Gabriele Toietta, Viraj P. Mane, Milton J. Finegold, Philip Ng, and Arthur L. Beaudet of BCM and Drs. Wilma S. Norona and A...

Cousin of Asian super termite invades Florida

...stain underground colonies. The chemical has a low toxicity to humans and the environment. Less than one gram kills an entire colony containing millions of termites. The control is marketed worldwide as the Sentricon Termite Colony Elimination System by Dow AgroSciences. ...

New miniaturised chip dramatically reduces time taken for DNA analysis

...strains in foodborne illnesses and testing genetic toxicity in new drugs. Once mass production of the sensors ...ions or to find criminal evidence; and testing the toxicity of different drugs to establish what damage they may cause to the DNA molecule of disease-causing mi...

Critical step traced in anthrax infection

... cell to set off a chain of events leading to cell toxicity and death. Protective antigen (PA) is one of these proteins, and after binding to the cell, seven copies of it assemble into a specific complex that is capable of forming a pore in a cellular membrane. The pore permits the other two proteins, lethal ...

MIT engineers an anti-cancer smart bomb

...damental challenges in cancer chemotherapy are its toxicity to healthy cells and drug resistance by cancer cel...e tumor, stopped angiogenesis and avoided systemic toxicity much better than other treatment and delivery variations. But it is patient survival and quality of...

Purdue scientists may have found key to halting spinal cord damage

...es much longer, for several days at least, and its toxicity is well documented." For example, acrolein has long been known to cause cancer when its concentration in the body rises, and not much is needed to be dangerous. When a person inhales smog or tobacco smoke, for example, the fluids lining the respirat...

Pinpointing the cause of a neurodegenerative disorder

...e beyond the glutamine that's really mediating the toxicity of the protein." Those conclusions were based, in part, on experiments in mice that showed that increased levels of normal Ataxin-1 can cause the pathology of SCA1. Turning to the fruit fly, Drosophila, a favorite of geneticists, Zoghbi and her coll...

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